FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333727> ?p ?o ?g. }

• W4313333727 endingPage "1203" @default.
• W4313333727 startingPage "1198" @default.
• W4313333727 abstract "Abstract Cholera toxin (CT) and its B subunit (CTB) are potent immunogens and adjuvants that, either alone or linked to protein Ags, can stimulate mucosal immune responses, modulate the induction of oral tolerance, and stimulate IgA isotype switching. The present studies addressed the mechanisms by which CT and CTB promote IgA switching. CT and rCTB, in the presence of IL-2, significantly increased IgA isotype switching at the clonal level in populations of purified and LPS-activated murine surface IgA− spleen B cells, as determined by ELISA, enzyme linked immunospot assays, and limiting dilution analysis. The IgA stimulatory effects of CT and CTB were independent of the A subunit of CT. CTB and CT did not increase the secretory rate of IgA-producing cells or the clonal burst size of IgA clones, and did inhibit B cell growth. Because TGF-β1 also inhibits B cell growth and promotes IgA switching, further studies tested whether the activity of CTB and CT on IgA isotype switching was mediated through TGF-β1. Anti-TGF-β Ab and soluble TGF-β1 type IIR inhibited CTB- and CT-stimulated IgA isotype switching. Furthermore, increased TGF-β1 mRNA levels and bioactive TGF-β1, within a range shown to induce IgA isotype switching, were detected in cultures of surface IgA− B cells stimulated with CT or CTB and IL-2. These data indicate that CTB- and CT-stimulated IgA isotype switching are mediated through TGF-β1. The finding that CTB up-regulates TGF-β1 activity has important implications for understanding the mechanisms by which CTB promotes both IgA mucosal immunity and oral tolerance." @default.
• W4313333727 created "2023-01-06" @default.
• W4313333727 creator A5007202760 @default.
• W4313333727 creator A5058211638 @default.
• W4313333727 creator A5072190618 @default.
• W4313333727 creator A5081059622 @default.
• W4313333727 creator A5090690603 @default.
• W4313333727 date "1998-02-01" @default.
• W4313333727 modified "2023-10-11" @default.
• W4313333727 title "Cholera Toxin and Cholera Toxin B Subunit Induce IgA Switching Through the Action of TGF-β1" @default.
• W4313333727 cites W1486323853 @default.
• W4313333727 cites W1490799008 @default.
• W4313333727 cites W1491077830 @default.
• W4313333727 cites W1504182415 @default.
• W4313333727 cites W1522262882 @default.
• W4313333727 cites W1524266249 @default.
• W4313333727 cites W1548168957 @default.
• W4313333727 cites W1564309137 @default.
• W4313333727 cites W1568856289 @default.
• W4313333727 cites W1571297909 @default.
• W4313333727 cites W1585428065 @default.
• W4313333727 cites W1590141303 @default.
• W4313333727 cites W1608791497 @default.
• W4313333727 cites W1652558138 @default.
• W4313333727 cites W1665745901 @default.
• W4313333727 cites W1858329533 @default.
• W4313333727 cites W1899754071 @default.
• W4313333727 cites W1964262147 @default.
• W4313333727 cites W1993933931 @default.
• W4313333727 cites W2007165330 @default.
• W4313333727 cites W2010210997 @default.
• W4313333727 cites W2025445086 @default.
• W4313333727 cites W2027366621 @default.
• W4313333727 cites W2032626982 @default.
• W4313333727 cites W2064566876 @default.
• W4313333727 cites W2069644412 @default.
• W4313333727 cites W2075540274 @default.
• W4313333727 cites W2081062408 @default.
• W4313333727 cites W2083033324 @default.
• W4313333727 cites W2097013962 @default.
• W4313333727 cites W2097247605 @default.
• W4313333727 cites W2124086093 @default.
• W4313333727 cites W2134927936 @default.
• W4313333727 cites W2148341340 @default.
• W4313333727 cites W2149849615 @default.
• W4313333727 cites W2156619629 @default.
• W4313333727 cites W2159012191 @default.
• W4313333727 cites W2161195123 @default.
• W4313333727 cites W2165885428 @default.
• W4313333727 cites W2211987955 @default.
• W4313333727 cites W2279077825 @default.
• W4313333727 cites W2292337439 @default.
• W4313333727 doi "https://doi.org/10.4049/jimmunol.160.3.1198" @default.
• W4313333727 hasPublicationYear "1998" @default.
• W4313333727 type Work @default.
• W4313333727 citedByCount "40" @default.
• W4313333727 countsByYear W43133337272013 @default.
• W4313333727 countsByYear W43133337272014 @default.
• W4313333727 countsByYear W43133337272015 @default.
• W4313333727 countsByYear W43133337272020 @default.
• W4313333727 countsByYear W43133337272021 @default.
• W4313333727 countsByYear W43133337272022 @default.
• W4313333727 crossrefType "journal-article" @default.
• W4313333727 hasAuthorship W4313333727A5007202760 @default.
• W4313333727 hasAuthorship W4313333727A5058211638 @default.
• W4313333727 hasAuthorship W4313333727A5072190618 @default.
• W4313333727 hasAuthorship W4313333727A5081059622 @default.
• W4313333727 hasAuthorship W4313333727A5090690603 @default.
• W4313333727 hasBestOaLocation W43133337271 @default.
• W4313333727 hasConcept C118131993 @default.
• W4313333727 hasConcept C137756551 @default.
• W4313333727 hasConcept C159654299 @default.
• W4313333727 hasConcept C203014093 @default.
• W4313333727 hasConcept C2777006276 @default.
• W4313333727 hasConcept C2777991845 @default.
• W4313333727 hasConcept C2778453870 @default.
• W4313333727 hasConcept C2779102806 @default.
• W4313333727 hasConcept C2780898057 @default.
• W4313333727 hasConcept C542903549 @default.
• W4313333727 hasConcept C86803240 @default.
• W4313333727 hasConcept C8891405 @default.
• W4313333727 hasConcept C89423630 @default.
• W4313333727 hasConcept C95444343 @default.
• W4313333727 hasConceptScore W4313333727C118131993 @default.
• W4313333727 hasConceptScore W4313333727C137756551 @default.
• W4313333727 hasConceptScore W4313333727C159654299 @default.
• W4313333727 hasConceptScore W4313333727C203014093 @default.
• W4313333727 hasConceptScore W4313333727C2777006276 @default.
• W4313333727 hasConceptScore W4313333727C2777991845 @default.
• W4313333727 hasConceptScore W4313333727C2778453870 @default.
• W4313333727 hasConceptScore W4313333727C2779102806 @default.
• W4313333727 hasConceptScore W4313333727C2780898057 @default.
• W4313333727 hasConceptScore W4313333727C542903549 @default.
• W4313333727 hasConceptScore W4313333727C86803240 @default.
• W4313333727 hasConceptScore W4313333727C8891405 @default.
• W4313333727 hasConceptScore W4313333727C89423630 @default.
• W4313333727 hasConceptScore W4313333727C95444343 @default.
• W4313333727 hasIssue "3" @default.

• next