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• W4313333732 startingPage "2254" @default.
• W4313333732 abstract "Abstract Developing thymocytes that give rise to CD8+ (cytotoxic) and CD4+ (helper) αβ-TCR T lymphocytes go through progressive stages of expression of coreceptors CD8 and CD4 from being negative for both (the double-negative stage), to coexpressing both (the double-positive (DP) stage), to a mutually exclusive sublineage-specific expression of one or the other (the single-positive (SP) stage). To delineate the mechanisms underlying regulation of CD8 during these developmental transitions, we have examined expression of a series of mouse CD8α gene constructs in developing T cells of conventional and CD8α “knock-out” transgenic mice. Our results indicate that cis-active transcriptional control sequences essential for stage- and sublineage-specific expression lie within a 5′ 40-kb segment of the CD8 locus, ∼12 kb upstream of the CD8α gene. Studies to characterize and sublocalize these cis sequences showed that a 17-kb 5′ subfragment is able to direct expression of the CD8α gene up to the CD3intermediate DP stage but not in more mature DP or SP cells. These results indicate that stage-specific expression of CD8α in developing T cells is mediated by the differential activity of multiple functionally distinct cis-active transcriptional control mechanisms. It will be important to determine the relationship of “switching” between these cis mechanisms and selection." @default.
• W4313333732 created "2023-01-06" @default.
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• W4313333732 date "1998-09-01" @default.
• W4313333732 modified "2023-10-18" @default.
• W4313333732 title "Distinct Stage-Specific <i>cis</i>-Active Transcriptional Mechanisms Control Expression of T Cell Coreceptor CD8α at Double- and Single-Positive Stages of Thymic Development" @default.
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• W4313333732 doi "https://doi.org/10.4049/jimmunol.161.5.2254" @default.
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