Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333739> ?p ?o ?g. }
- W4313333739 endingPage "2699" @default.
- W4313333739 startingPage "2692" @default.
- W4313333739 abstract "Abstract IFN-α is used as a maintenance therapy in patients with multiple myeloma, but its benefit is a matter of controversy. In vitro studies show that IFN-α can both stimulate and inhibit myeloma cell proliferation. We have tested the effect of IFN-α on the survival of myeloma cell lines and primary plasma cells. IFN-α significantly reduced the apoptosis induced by removal of IL-6 in four IL-6-dependent myeloma cell lines. It also reduced the level of apoptosis induced by dexamethasone in these cell lines as well as in purified primary myeloma cells from seven patients. IFN-α promoted the survival of myeloma cells, which, following removal of IL-6, were blocked in G1 and died. However, unlike IL-6, IFN-α-treated cells remained mainly blocked in the G1 phase of the cycle. While the effects of IL-6 are mediated through stimulation of its gp130 receptor subunit, the IFN-α-induced survival of myeloma cells was independent of gp130 transducer activation (as demonstrated using a neutralizing anti-gp130 Ab). However, the signal transduction cascades activated by these two cytokines share at least some common elements, since stimulation with either IFN-α or IL-6 resulted in STAT3 phosphorylation. These results indicate that IFN-α promotes the survival, but not the proliferation, of myeloma cells, preventing the apoptosis induced by removal of IL-6 or addition of dexamethasone. This survival factor activity may explain the conflicting reports on the effects of IFN-α on myeloma cell proliferation." @default.
- W4313333739 created "2023-01-06" @default.
- W4313333739 creator A5018942492 @default.
- W4313333739 creator A5028122476 @default.
- W4313333739 creator A5040819874 @default.
- W4313333739 creator A5047257257 @default.
- W4313333739 creator A5076949118 @default.
- W4313333739 creator A5078635665 @default.
- W4313333739 date "1998-09-15" @default.
- W4313333739 modified "2023-10-16" @default.
- W4313333739 title "IFN-α Is a Survival Factor for Human Myeloma Cells and Reduces Dexamethasone-Induced Apoptosis" @default.
- W4313333739 cites W1493466161 @default.
- W4313333739 cites W1496384357 @default.
- W4313333739 cites W1568956696 @default.
- W4313333739 cites W1602943807 @default.
- W4313333739 cites W1967266848 @default.
- W4313333739 cites W1972931798 @default.
- W4313333739 cites W1973199949 @default.
- W4313333739 cites W1979231241 @default.
- W4313333739 cites W1986785442 @default.
- W4313333739 cites W1988917700 @default.
- W4313333739 cites W1991787503 @default.
- W4313333739 cites W1995057778 @default.
- W4313333739 cites W2007119824 @default.
- W4313333739 cites W2025287109 @default.
- W4313333739 cites W2028071443 @default.
- W4313333739 cites W2030624761 @default.
- W4313333739 cites W2038428454 @default.
- W4313333739 cites W2040356316 @default.
- W4313333739 cites W2047738065 @default.
- W4313333739 cites W2049858476 @default.
- W4313333739 cites W2059938714 @default.
- W4313333739 cites W2061875429 @default.
- W4313333739 cites W2078532650 @default.
- W4313333739 cites W2079668255 @default.
- W4313333739 cites W2097271087 @default.
- W4313333739 cites W2112106256 @default.
- W4313333739 cites W2119120508 @default.
- W4313333739 cites W2164711235 @default.
- W4313333739 cites W2290337133 @default.
- W4313333739 cites W2474873081 @default.
- W4313333739 cites W4243692027 @default.
- W4313333739 cites W4244689496 @default.
- W4313333739 cites W4247708152 @default.
- W4313333739 cites W4250386168 @default.
- W4313333739 doi "https://doi.org/10.4049/jimmunol.161.6.2692" @default.
- W4313333739 hasPublicationYear "1998" @default.
- W4313333739 type Work @default.
- W4313333739 citedByCount "34" @default.
- W4313333739 countsByYear W43133337392012 @default.
- W4313333739 countsByYear W43133337392013 @default.
- W4313333739 countsByYear W43133337392018 @default.
- W4313333739 countsByYear W43133337392019 @default.
- W4313333739 countsByYear W43133337392021 @default.
- W4313333739 crossrefType "journal-article" @default.
- W4313333739 hasAuthorship W4313333739A5018942492 @default.
- W4313333739 hasAuthorship W4313333739A5028122476 @default.
- W4313333739 hasAuthorship W4313333739A5040819874 @default.
- W4313333739 hasAuthorship W4313333739A5047257257 @default.
- W4313333739 hasAuthorship W4313333739A5076949118 @default.
- W4313333739 hasAuthorship W4313333739A5078635665 @default.
- W4313333739 hasBestOaLocation W43133337391 @default.
- W4313333739 hasConcept C126037660 @default.
- W4313333739 hasConcept C134018914 @default.
- W4313333739 hasConcept C190283241 @default.
- W4313333739 hasConcept C203014093 @default.
- W4313333739 hasConcept C2776364478 @default.
- W4313333739 hasConcept C2778690821 @default.
- W4313333739 hasConcept C2778923194 @default.
- W4313333739 hasConcept C2780401358 @default.
- W4313333739 hasConcept C502942594 @default.
- W4313333739 hasConcept C54355233 @default.
- W4313333739 hasConcept C55493867 @default.
- W4313333739 hasConcept C81885089 @default.
- W4313333739 hasConcept C86803240 @default.
- W4313333739 hasConceptScore W4313333739C126037660 @default.
- W4313333739 hasConceptScore W4313333739C134018914 @default.
- W4313333739 hasConceptScore W4313333739C190283241 @default.
- W4313333739 hasConceptScore W4313333739C203014093 @default.
- W4313333739 hasConceptScore W4313333739C2776364478 @default.
- W4313333739 hasConceptScore W4313333739C2778690821 @default.
- W4313333739 hasConceptScore W4313333739C2778923194 @default.
- W4313333739 hasConceptScore W4313333739C2780401358 @default.
- W4313333739 hasConceptScore W4313333739C502942594 @default.
- W4313333739 hasConceptScore W4313333739C54355233 @default.
- W4313333739 hasConceptScore W4313333739C55493867 @default.
- W4313333739 hasConceptScore W4313333739C81885089 @default.
- W4313333739 hasConceptScore W4313333739C86803240 @default.
- W4313333739 hasIssue "6" @default.
- W4313333739 hasLocation W43133337391 @default.
- W4313333739 hasOpenAccess W4313333739 @default.
- W4313333739 hasPrimaryLocation W43133337391 @default.
- W4313333739 hasRelatedWork W1872754503 @default.
- W4313333739 hasRelatedWork W1979186288 @default.
- W4313333739 hasRelatedWork W2026496740 @default.
- W4313333739 hasRelatedWork W2033697399 @default.
- W4313333739 hasRelatedWork W2147671525 @default.
- W4313333739 hasRelatedWork W2313147787 @default.