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- W4313333763 endingPage "1850" @default.
- W4313333763 startingPage "1843" @default.
- W4313333763 abstract "Abstract A population of CD4+ α−β+ T cells increases in the mucosal and peripheral lymphoid tissues of TCRα-chain-deficient mice with inflammatory bowel disease. The α−β+ T cells, which produce predominantly IL-4, mediate the proliferation of colonic epithelial crypts and the infiltration of large numbers of IgA-producing plasma cells into the lamina propria of the colon. To examine whether enteric Ags were recognized by a population of monoclonal α−β+ T cells leading to the intestinal inflammation, we examined the usage and clonotypes of TCR expressed by the α−β+ T cells in TCRα-chain-deficient mice with inflammatory bowel disease. Analyses of immunoprecipitates by two dimensional electrophoresis and single-cell RT-PCR revealed that TCR of the α−β+ T cells was a homodimer of β-chains that was capable of recognizing luminal bacterial Ags. PCR single-strand conformation polymorphism analysis of TCR Vβ transcripts revealed monoclonal accumulation of the α−β+ T cells in the colonic lamina propria of the diseased mice. DNA sequencing revealed the accumulation of the α−β+ T cells with the same CDR3 sequences in the colon. These findings suggest that the pathogenic CD4+ α−β+ T cells expressing a homodimeric form of the TCRβ-chains can be clonally expanded upon the stimulation with gut-derived Ags." @default.
- W4313333763 created "2023-01-06" @default.
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- W4313333763 date "1999-02-01" @default.
- W4313333763 modified "2023-10-17" @default.
- W4313333763 title "Clonal Expansion of CD4+ TCRββ+ T Cells in TCR α-Chain- Deficient Mice by Gut-Derived Antigens" @default.
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- W4313333763 doi "https://doi.org/10.4049/jimmunol.162.3.1843" @default.
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