Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333771> ?p ?o ?g. }
- W4313333771 endingPage "4718" @default.
- W4313333771 startingPage "4709" @default.
- W4313333771 abstract "Abstract IL-4 was found to be the essential differentiation factor for Th2 cells and simultaneously to be a potent inhibitor of Th1 development that is induced by IFN-γ and IL-12. Furthermore, it was demonstrated that TGF-β can also inhibit Th1 development. In this work, we demonstrate that polyclonal activation of Mel-14highCD4+ T cells by immobilized anti-αβTCR mAb together with a mixture of IL-4 and TGF-β can lead to the development of both Th1 and Th2 cells, depending on the concentration of these cytokines. Additional experiments revealed that Th1 induction by a combination of IL-4 and TGF-β depends on the presence of endogenous IFN-γ, and that this alternative Th1 development is further enhanced by IL-12, but is not dependent on this cytokine. Moreover, naive OVA323–339-specific Th cells that were stimulated by APCs and OVA323–339 peptide differentiated toward Th1 cells after priming in the presence of IL-4 in combination with TGF-β. Hence, this finding confirmed the results obtained by polyclonal activation of naive CD4+ Th cells and implicates that this alternative Th1 development may also occur in vivo under the influence of TGF-β and IL-4 independently of the Th1-promoting effect of IL-12." @default.
- W4313333771 created "2023-01-06" @default.
- W4313333771 creator A5007248731 @default.
- W4313333771 creator A5017974169 @default.
- W4313333771 creator A5028844436 @default.
- W4313333771 creator A5036396543 @default.
- W4313333771 creator A5039315521 @default.
- W4313333771 creator A5059579735 @default.
- W4313333771 creator A5072219964 @default.
- W4313333771 creator A5084852255 @default.
- W4313333771 date "1998-11-01" @default.
- W4313333771 modified "2023-10-16" @default.
- W4313333771 title "IL-4 in Combination with TGF-β Favors an Alternative Pathway of Th1 Development Independent of IL-12" @default.
- W4313333771 cites W1489642554 @default.
- W4313333771 cites W1511950399 @default.
- W4313333771 cites W1522700610 @default.
- W4313333771 cites W1525833221 @default.
- W4313333771 cites W1526393380 @default.
- W4313333771 cites W1532660854 @default.
- W4313333771 cites W1547565061 @default.
- W4313333771 cites W1553420527 @default.
- W4313333771 cites W1556295451 @default.
- W4313333771 cites W1621064629 @default.
- W4313333771 cites W1634158134 @default.
- W4313333771 cites W1767424672 @default.
- W4313333771 cites W1818230223 @default.
- W4313333771 cites W1894525365 @default.
- W4313333771 cites W1942668068 @default.
- W4313333771 cites W1954630018 @default.
- W4313333771 cites W1972922050 @default.
- W4313333771 cites W1976908672 @default.
- W4313333771 cites W1979514172 @default.
- W4313333771 cites W1988317772 @default.
- W4313333771 cites W1997620800 @default.
- W4313333771 cites W2000048275 @default.
- W4313333771 cites W2005246059 @default.
- W4313333771 cites W2007245529 @default.
- W4313333771 cites W2010216035 @default.
- W4313333771 cites W2017163770 @default.
- W4313333771 cites W2017596457 @default.
- W4313333771 cites W2017684091 @default.
- W4313333771 cites W2022606988 @default.
- W4313333771 cites W2027878354 @default.
- W4313333771 cites W2032980904 @default.
- W4313333771 cites W2036166448 @default.
- W4313333771 cites W2037061225 @default.
- W4313333771 cites W2042616736 @default.
- W4313333771 cites W2044585677 @default.
- W4313333771 cites W2045008512 @default.
- W4313333771 cites W2056859114 @default.
- W4313333771 cites W2061140050 @default.
- W4313333771 cites W2062528530 @default.
- W4313333771 cites W2065367149 @default.
- W4313333771 cites W2071358669 @default.
- W4313333771 cites W2077915163 @default.
- W4313333771 cites W2079185370 @default.
- W4313333771 cites W2081070214 @default.
- W4313333771 cites W2092192751 @default.
- W4313333771 cites W2100699905 @default.
- W4313333771 cites W2123511115 @default.
- W4313333771 cites W2139144899 @default.
- W4313333771 cites W2141679700 @default.
- W4313333771 cites W2141895910 @default.
- W4313333771 cites W2149255798 @default.
- W4313333771 cites W2154122248 @default.
- W4313333771 cites W2156471525 @default.
- W4313333771 cites W2161916137 @default.
- W4313333771 doi "https://doi.org/10.4049/jimmunol.161.9.4709" @default.
- W4313333771 hasPublicationYear "1998" @default.
- W4313333771 type Work @default.
- W4313333771 citedByCount "28" @default.
- W4313333771 countsByYear W43133337712012 @default.
- W4313333771 countsByYear W43133337712014 @default.
- W4313333771 countsByYear W43133337712016 @default.
- W4313333771 crossrefType "journal-article" @default.
- W4313333771 hasAuthorship W4313333771A5007248731 @default.
- W4313333771 hasAuthorship W4313333771A5017974169 @default.
- W4313333771 hasAuthorship W4313333771A5028844436 @default.
- W4313333771 hasAuthorship W4313333771A5036396543 @default.
- W4313333771 hasAuthorship W4313333771A5039315521 @default.
- W4313333771 hasAuthorship W4313333771A5059579735 @default.
- W4313333771 hasAuthorship W4313333771A5072219964 @default.
- W4313333771 hasAuthorship W4313333771A5084852255 @default.
- W4313333771 hasBestOaLocation W43133337711 @default.
- W4313333771 hasConcept C100701293 @default.
- W4313333771 hasConcept C118131993 @default.
- W4313333771 hasConcept C150903083 @default.
- W4313333771 hasConcept C159654299 @default.
- W4313333771 hasConcept C185592680 @default.
- W4313333771 hasConcept C191732599 @default.
- W4313333771 hasConcept C203014093 @default.
- W4313333771 hasConcept C207001950 @default.
- W4313333771 hasConcept C2776090121 @default.
- W4313333771 hasConcept C2778690821 @default.
- W4313333771 hasConcept C59822182 @default.
- W4313333771 hasConcept C81444415 @default.
- W4313333771 hasConcept C86803240 @default.
- W4313333771 hasConcept C8891405 @default.