FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333772> ?p ?o ?g. }

• W4313333772 endingPage "3149" @default.
• W4313333772 startingPage "3143" @default.
• W4313333772 abstract "Abstract IL-10-deficient (IL-10−/−) mice develop chronic enterocolitis mediated by CD4+ Th1 cells producing IFN-γ. Because IL-12 can promote Th1 development and IFN-γ production, the ability of neutralizing anti-IL-12 mAb to modulate colitis in IL-10−/− mice was investigated. Anti-IL-12 mAb treatment completely prevented disease development in young IL-10−/− mice. Treatment of adult mice resulted in significant amelioration of established disease accompanied by reduced numbers of mesenteric lymph node and colonic CD4+ T cells and of mesenteric lymph node T cells spontaneously producing IFN-γ. In contrast, anti-IFN-γ mAb had minimal effect on disease reversal, despite a significant preventative effect in young mice. These findings suggested that IL-12 sustains colitis by supporting the expansion of differentiated Th1 cells that mediate disease independently of their IFN-γ production. This conclusion was supported by the finding that anti-IL-12 mAb greatly diminished the ability of a limited number of CD4+ T cells expressing high levels of CD45RB from diseased IL-10−/− mice to expand and cause colitis in recombination-activating gene-2−/− recipients, while anti-IFN-γ mAb had no effect. Furthermore, IL-12 could support pathogenic IL-10−/− T cells stimulated in vitro in the absence of IL-2. While these studies show that IL-12 plays an important role in sustaining activated Th1 cells during the chronic phase of disease, the inability of anti-IL-12 mAb to abolish established colitis or completely prevent disease transfer by Th1 cells suggests that additional factors contribute to disease maintenance." @default.
• W4313333772 created "2023-01-06" @default.
• W4313333772 creator A5009031195 @default.
• W4313333772 creator A5057280635 @default.
• W4313333772 creator A5064162904 @default.
• W4313333772 creator A5073120155 @default.
• W4313333772 creator A5084923988 @default.
• W4313333772 creator A5086892723 @default.
• W4313333772 date "1998-09-15" @default.
• W4313333772 modified "2023-10-18" @default.
• W4313333772 title "IL-12, But Not IFN-γ, Plays a Major Role in Sustaining the Chronic Phase of Colitis in IL-10-Deficient Mice" @default.
• W4313333772 cites W1580094571 @default.
• W4313333772 cites W1600526298 @default.
• W4313333772 cites W1832936335 @default.
• W4313333772 cites W1909810986 @default.
• W4313333772 cites W1971119469 @default.
• W4313333772 cites W1976404927 @default.
• W4313333772 cites W1997638368 @default.
• W4313333772 cites W1998199590 @default.
• W4313333772 cites W2002061924 @default.
• W4313333772 cites W2012066742 @default.
• W4313333772 cites W2018075167 @default.
• W4313333772 cites W2026161448 @default.
• W4313333772 cites W2030491234 @default.
• W4313333772 cites W2031986276 @default.
• W4313333772 cites W2033270059 @default.
• W4313333772 cites W2034419904 @default.
• W4313333772 cites W2036500213 @default.
• W4313333772 cites W2049653889 @default.
• W4313333772 cites W2062922499 @default.
• W4313333772 cites W2063053561 @default.
• W4313333772 cites W2068697839 @default.
• W4313333772 cites W2070319044 @default.
• W4313333772 cites W2073648639 @default.
• W4313333772 cites W2074978521 @default.
• W4313333772 cites W2092192751 @default.
• W4313333772 cites W2102724444 @default.
• W4313333772 cites W2111199584 @default.
• W4313333772 cites W2134453100 @default.
• W4313333772 cites W2141679700 @default.
• W4313333772 cites W2142156809 @default.
• W4313333772 cites W2159549010 @default.
• W4313333772 cites W2165885428 @default.
• W4313333772 cites W2171831396 @default.
• W4313333772 cites W2395362254 @default.
• W4313333772 cites W249403745 @default.
• W4313333772 doi "https://doi.org/10.4049/jimmunol.161.6.3143" @default.
• W4313333772 hasPublicationYear "1998" @default.
• W4313333772 type Work @default.
• W4313333772 citedByCount "137" @default.
• W4313333772 countsByYear W43133337722012 @default.
• W4313333772 countsByYear W43133337722013 @default.
• W4313333772 countsByYear W43133337722014 @default.
• W4313333772 countsByYear W43133337722015 @default.
• W4313333772 countsByYear W43133337722017 @default.
• W4313333772 countsByYear W43133337722018 @default.
• W4313333772 countsByYear W43133337722019 @default.
• W4313333772 countsByYear W43133337722021 @default.
• W4313333772 countsByYear W43133337722022 @default.
• W4313333772 countsByYear W43133337722023 @default.
• W4313333772 crossrefType "journal-article" @default.
• W4313333772 hasAuthorship W4313333772A5009031195 @default.
• W4313333772 hasAuthorship W4313333772A5057280635 @default.
• W4313333772 hasAuthorship W4313333772A5064162904 @default.
• W4313333772 hasAuthorship W4313333772A5073120155 @default.
• W4313333772 hasAuthorship W4313333772A5084923988 @default.
• W4313333772 hasAuthorship W4313333772A5086892723 @default.
• W4313333772 hasConcept C126322002 @default.
• W4313333772 hasConcept C149532602 @default.
• W4313333772 hasConcept C154317977 @default.
• W4313333772 hasConcept C159654299 @default.
• W4313333772 hasConcept C202751555 @default.
• W4313333772 hasConcept C203014093 @default.
• W4313333772 hasConcept C2775862500 @default.
• W4313333772 hasConcept C2776090121 @default.
• W4313333772 hasConcept C2778260677 @default.
• W4313333772 hasConcept C2778690821 @default.
• W4313333772 hasConcept C2779134260 @default.
• W4313333772 hasConcept C2779237934 @default.
• W4313333772 hasConcept C2780849966 @default.
• W4313333772 hasConcept C542903549 @default.
• W4313333772 hasConcept C55493867 @default.
• W4313333772 hasConcept C71924100 @default.
• W4313333772 hasConcept C86803240 @default.
• W4313333772 hasConcept C8891405 @default.
• W4313333772 hasConcept C90375314 @default.
• W4313333772 hasConceptScore W4313333772C126322002 @default.
• W4313333772 hasConceptScore W4313333772C149532602 @default.
• W4313333772 hasConceptScore W4313333772C154317977 @default.
• W4313333772 hasConceptScore W4313333772C159654299 @default.
• W4313333772 hasConceptScore W4313333772C202751555 @default.
• W4313333772 hasConceptScore W4313333772C203014093 @default.
• W4313333772 hasConceptScore W4313333772C2775862500 @default.
• W4313333772 hasConceptScore W4313333772C2776090121 @default.
• W4313333772 hasConceptScore W4313333772C2778260677 @default.
• W4313333772 hasConceptScore W4313333772C2778690821 @default.
• W4313333772 hasConceptScore W4313333772C2779134260 @default.
• W4313333772 hasConceptScore W4313333772C2779237934 @default.

• next