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• W4313333776 startingPage "2094" @default.
• W4313333776 abstract "Abstract A critical role for CD40/CD154 interactions in the generation of protective cell-mediated tumor immunity has been demonstrated previously. Herein, we show that the failure to generate systemic tumor immunity in the absence of CD40/CD154 interactions correlates with an inhibition of Th1-type cytokine production following tumor vaccination. Furthermore, protective antitumor responses can be restored in CD40-deficient mice by the coadministration of CD40+/+ but not CD40−/− dendritic cells (DCs) with tumor Ag, suggesting that CD40 is critical for the maturation and function of DCs in vivo. Finally, we demonstrate that an IL-12-transduced but not a mock-transduced tumor vaccine induces systemic tumor immunity in anti-CD154-treated and CD154-deficient mice. These data suggest that impaired antitumor responses in the absence of CD40/CD154 interactions are the result of a lesion in APC function, namely IL-12 production, and that CD40 plays a critical role in the maturation of DCs in vivo." @default.
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• W4313333776 date "1998-09-01" @default.
• W4313333776 modified "2023-10-06" @default.
• W4313333776 title "Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity" @default.
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• W4313333776 doi "https://doi.org/10.4049/jimmunol.161.5.2094" @default.
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