FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333778> ?p ?o ?g. }

• W4313333778 endingPage "2888" @default.
• W4313333778 startingPage "2881" @default.
• W4313333778 abstract "Abstract We have recently demonstrated that the parasite Leishmania donovani and its surface molecule, lipophosphoglycan (LPG), can activate HIV-1 replication in monocytoid cells. Our present interest was to determine whether LPG could also up-regulate HIV-1 transcription in T cells. Using a CD4-positive human lymphoid T cell line (1G5) containing a stably integrated HIV-1 long terminal repeat (LTR)-luciferase construct, we found that LPG is a potent inducer of HIV-1 LTR activity. Treatment of 1G5 cells with signaling antagonists revealed that protein tyrosine kinase- and protein kinase A-dependent pathways were actively participating in the LPG-induced enhancement of HIV-1 LTR-driven activity. Transfection of Jurkat E6.1 cells with plasmids containing wild-type and nuclear factor-κB (NF-κB)-mutated HIV-1 LTR-luciferase constructs has suggested a role for NF-κB binding sites in the LPG-mediated induction of HIV-1 LTR activity. An LPG-induced binding factor specific to the NF-κB consensus sequences could be observed using electrophoretic mobility shift assay. Finally, transfection experiments performed with a vector containing HIV-1 κB binding sites only showed similar LPG-mediated induction, which was abrogated by sodium salicylate, a known NF-κB inhibitor. We thus demonstrate that the LPG-mediated induction of HIV-1 LTR activity in T cells involves several second messengers culminating in activation of HIV-1 LTR-driven transcription via NF-κB-binding consensus sequences. In conclusion, these results reinforce the idea that L. donovani is a putative cofactor in HIV-1 pathogenesis." @default.
• W4313333778 created "2023-01-06" @default.
• W4313333778 creator A5003294144 @default.
• W4313333778 creator A5021436834 @default.
• W4313333778 creator A5039852039 @default.
• W4313333778 creator A5073259394 @default.
• W4313333778 date "1998-03-15" @default.
• W4313333778 modified "2023-10-16" @default.
• W4313333778 title "The Lipophosphoglycan of<i>Leishmania</i> <i>donovani</i>Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-κB Elements" @default.
• W4313333778 cites W1519955282 @default.
• W4313333778 cites W1549845633 @default.
• W4313333778 cites W1556531314 @default.
• W4313333778 cites W1566431186 @default.
• W4313333778 cites W1614525551 @default.
• W4313333778 cites W1830489709 @default.
• W4313333778 cites W1866793215 @default.
• W4313333778 cites W1880476205 @default.
• W4313333778 cites W1961668980 @default.
• W4313333778 cites W1963954954 @default.
• W4313333778 cites W1965168699 @default.
• W4313333778 cites W1971391786 @default.
• W4313333778 cites W1977282539 @default.
• W4313333778 cites W1978869673 @default.
• W4313333778 cites W1980496424 @default.
• W4313333778 cites W1983476487 @default.
• W4313333778 cites W1987189799 @default.
• W4313333778 cites W1991670386 @default.
• W4313333778 cites W2001363425 @default.
• W4313333778 cites W2005071171 @default.
• W4313333778 cites W2010237936 @default.
• W4313333778 cites W2010673210 @default.
• W4313333778 cites W2015326137 @default.
• W4313333778 cites W2020153135 @default.
• W4313333778 cites W2020700449 @default.
• W4313333778 cites W2023243934 @default.
• W4313333778 cites W2029752579 @default.
• W4313333778 cites W2036890038 @default.
• W4313333778 cites W2043541788 @default.
• W4313333778 cites W2045157808 @default.
• W4313333778 cites W2048671183 @default.
• W4313333778 cites W2051294148 @default.
• W4313333778 cites W2052260301 @default.
• W4313333778 cites W2052387345 @default.
• W4313333778 cites W2052573307 @default.
• W4313333778 cites W2057222889 @default.
• W4313333778 cites W2061903251 @default.
• W4313333778 cites W2065114401 @default.
• W4313333778 cites W2070853191 @default.
• W4313333778 cites W2073993982 @default.
• W4313333778 cites W2075328121 @default.
• W4313333778 cites W2078082514 @default.
• W4313333778 cites W2085721436 @default.
• W4313333778 cites W2088493593 @default.
• W4313333778 cites W2089471930 @default.
• W4313333778 cites W2089719814 @default.
• W4313333778 cites W2094646101 @default.
• W4313333778 cites W2095860222 @default.
• W4313333778 cites W2096110335 @default.
• W4313333778 cites W2106031221 @default.
• W4313333778 cites W2112139849 @default.
• W4313333778 cites W2113282092 @default.
• W4313333778 cites W2116014786 @default.
• W4313333778 cites W2122247224 @default.
• W4313333778 cites W2123778842 @default.
• W4313333778 cites W2130703256 @default.
• W4313333778 cites W2132269792 @default.
• W4313333778 cites W2133764756 @default.
• W4313333778 cites W2137267461 @default.
• W4313333778 cites W2138974828 @default.
• W4313333778 cites W2141578443 @default.
• W4313333778 cites W2142161087 @default.
• W4313333778 cites W2142771538 @default.
• W4313333778 cites W2149447688 @default.
• W4313333778 cites W2150151832 @default.
• W4313333778 cites W2151892297 @default.
• W4313333778 cites W2152450517 @default.
• W4313333778 cites W2153607114 @default.
• W4313333778 cites W2158884355 @default.
• W4313333778 cites W21746843 @default.
• W4313333778 cites W2339006876 @default.
• W4313333778 cites W2421037982 @default.
• W4313333778 cites W4300667299 @default.
• W4313333778 doi "https://doi.org/10.4049/jimmunol.160.6.2881" @default.
• W4313333778 hasPublicationYear "1998" @default.
• W4313333778 type Work @default.
• W4313333778 citedByCount "22" @default.
• W4313333778 countsByYear W43133337782012 @default.
• W4313333778 countsByYear W43133337782013 @default.
• W4313333778 countsByYear W43133337782014 @default.
• W4313333778 countsByYear W43133337782022 @default.
• W4313333778 countsByYear W43133337782023 @default.
• W4313333778 crossrefType "journal-article" @default.
• W4313333778 hasAuthorship W4313333778A5003294144 @default.
• W4313333778 hasAuthorship W4313333778A5021436834 @default.
• W4313333778 hasAuthorship W4313333778A5039852039 @default.
• W4313333778 hasAuthorship W4313333778A5073259394 @default.
• W4313333778 hasConcept C104317684 @default.
• W4313333778 hasConcept C111335760 @default.

• next