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• W4313333782 startingPage "3217" @default.
• W4313333782 abstract "Abstract Two conformationally distinct and stable forms of Qa-1b, one strongly associated with β2-microglobulin (β2m) and the other associated with a novel molecule, gp44, were observed during immunochemical studies on the expression of Qa-1b molecules in mouse spleen cells. Both forms are efficiently processed and expressed at the cell surface. However, a large proportion of Qa-1b was found to be disulfide linked to gp44 without any detectable β2m. In TAP1-deficient mice, both forms undergo carbohydrate processing and are expressed on the cell surface, suggesting that they may traffic using a pathway not requiring a TAP association step. Consistent with this, size exclusion chromatography of newly synthesized class I molecules shows that high molecular mass complexes containing H-2Kk do not contain Qa-1b. Although Qa-1b can be stably expressed without β2m, there was no maturation of either form in cells from β2m-deficient mice where heavy chains were rapidly degraded. These results suggest that Qa-1b, like most other class I molecules, requires β2m for an initial folding step. However, β2m is not essential for subsequent processing of Qa-1b molecules." @default.
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• W4313333782 date "1998-04-01" @default.
• W4313333782 modified "2023-10-16" @default.
• W4313333782 title "Maturation of Qa-1b Class I Molecules Requires β2-Microglobulin But Is TAP Independent" @default.
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• W4313333782 doi "https://doi.org/10.4049/jimmunol.160.7.3217" @default.
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