Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333783> ?p ?o ?g. }
- W4313333783 endingPage "5048" @default.
- W4313333783 startingPage "5045" @default.
- W4313333783 abstract "Abstract HLA-B27 has a striking association with inflammatory arthritis. We show that free HLA-B27 heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys67 in their extracellular α1 domain. Despite the absence of β2-microglobulin, HLA-B27 heavy chain homodimers (termed HC-B27) were stabilized by a known peptide epitope. HC-B27 complexes were recognized by the conformation-specific Ab W6/32, but not the ME1 Ab. Surface labeling and immunoprecipitation demonstrated the presence of similar W6/32-reactive free heavy chains at the surface of HLA-B27-transfected T2 cells. HC-B27 homodimer formation might explain the ability of HLA-B27 to induce spondyloarthropathy in β2-microglobulin-deficient mice." @default.
- W4313333783 created "2023-01-06" @default.
- W4313333783 creator A5023823568 @default.
- W4313333783 creator A5042652724 @default.
- W4313333783 creator A5068458400 @default.
- W4313333783 creator A5089128714 @default.
- W4313333783 date "1999-05-01" @default.
- W4313333783 modified "2023-10-16" @default.
- W4313333783 title "Cutting Edge: HLA-B27 Can Form a Novel β2-Microglobulin-Free Heavy Chain Homodimer Structure" @default.
- W4313333783 cites W1575816312 @default.
- W4313333783 cites W1974823499 @default.
- W4313333783 cites W1975088706 @default.
- W4313333783 cites W1987002856 @default.
- W4313333783 cites W1988829774 @default.
- W4313333783 cites W1995138538 @default.
- W4313333783 cites W2020857625 @default.
- W4313333783 cites W2036130921 @default.
- W4313333783 cites W2046362928 @default.
- W4313333783 cites W2049472329 @default.
- W4313333783 cites W2061613789 @default.
- W4313333783 cites W2082526751 @default.
- W4313333783 cites W2083421134 @default.
- W4313333783 cites W2088768714 @default.
- W4313333783 cites W2090443272 @default.
- W4313333783 cites W2096644099 @default.
- W4313333783 cites W2104539850 @default.
- W4313333783 cites W2109782136 @default.
- W4313333783 cites W2117901432 @default.
- W4313333783 cites W2139838142 @default.
- W4313333783 cites W2144967303 @default.
- W4313333783 cites W2159404298 @default.
- W4313333783 cites W2167418901 @default.
- W4313333783 cites W2168932061 @default.
- W4313333783 doi "https://doi.org/10.4049/jimmunol.162.9.5045" @default.
- W4313333783 hasPublicationYear "1999" @default.
- W4313333783 type Work @default.
- W4313333783 citedByCount "161" @default.
- W4313333783 countsByYear W43133337832012 @default.
- W4313333783 countsByYear W43133337832013 @default.
- W4313333783 countsByYear W43133337832014 @default.
- W4313333783 countsByYear W43133337832015 @default.
- W4313333783 countsByYear W43133337832016 @default.
- W4313333783 countsByYear W43133337832017 @default.
- W4313333783 countsByYear W43133337832018 @default.
- W4313333783 countsByYear W43133337832019 @default.
- W4313333783 countsByYear W43133337832020 @default.
- W4313333783 countsByYear W43133337832021 @default.
- W4313333783 countsByYear W43133337832022 @default.
- W4313333783 countsByYear W43133337832023 @default.
- W4313333783 crossrefType "journal-article" @default.
- W4313333783 hasAuthorship W4313333783A5023823568 @default.
- W4313333783 hasAuthorship W4313333783A5042652724 @default.
- W4313333783 hasAuthorship W4313333783A5068458400 @default.
- W4313333783 hasAuthorship W4313333783A5089128714 @default.
- W4313333783 hasBestOaLocation W43133337831 @default.
- W4313333783 hasConcept C104317684 @default.
- W4313333783 hasConcept C12554922 @default.
- W4313333783 hasConcept C147483822 @default.
- W4313333783 hasConcept C153911025 @default.
- W4313333783 hasConcept C159654299 @default.
- W4313333783 hasConcept C185592680 @default.
- W4313333783 hasConcept C188280979 @default.
- W4313333783 hasConcept C195616568 @default.
- W4313333783 hasConcept C203014093 @default.
- W4313333783 hasConcept C21957315 @default.
- W4313333783 hasConcept C2778091532 @default.
- W4313333783 hasConcept C28406088 @default.
- W4313333783 hasConcept C36394416 @default.
- W4313333783 hasConcept C54009773 @default.
- W4313333783 hasConcept C55493867 @default.
- W4313333783 hasConcept C71829478 @default.
- W4313333783 hasConcept C84613547 @default.
- W4313333783 hasConcept C86803240 @default.
- W4313333783 hasConcept C95444343 @default.
- W4313333783 hasConceptScore W4313333783C104317684 @default.
- W4313333783 hasConceptScore W4313333783C12554922 @default.
- W4313333783 hasConceptScore W4313333783C147483822 @default.
- W4313333783 hasConceptScore W4313333783C153911025 @default.
- W4313333783 hasConceptScore W4313333783C159654299 @default.
- W4313333783 hasConceptScore W4313333783C185592680 @default.
- W4313333783 hasConceptScore W4313333783C188280979 @default.
- W4313333783 hasConceptScore W4313333783C195616568 @default.
- W4313333783 hasConceptScore W4313333783C203014093 @default.
- W4313333783 hasConceptScore W4313333783C21957315 @default.
- W4313333783 hasConceptScore W4313333783C2778091532 @default.
- W4313333783 hasConceptScore W4313333783C28406088 @default.
- W4313333783 hasConceptScore W4313333783C36394416 @default.
- W4313333783 hasConceptScore W4313333783C54009773 @default.
- W4313333783 hasConceptScore W4313333783C55493867 @default.
- W4313333783 hasConceptScore W4313333783C71829478 @default.
- W4313333783 hasConceptScore W4313333783C84613547 @default.
- W4313333783 hasConceptScore W4313333783C86803240 @default.
- W4313333783 hasConceptScore W4313333783C95444343 @default.
- W4313333783 hasIssue "9" @default.
- W4313333783 hasLocation W43133337831 @default.
- W4313333783 hasOpenAccess W4313333783 @default.
- W4313333783 hasPrimaryLocation W43133337831 @default.
- W4313333783 hasRelatedWork W1769674052 @default.