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• W4313333790 endingPage "2674" @default.
• W4313333790 startingPage "2665" @default.
• W4313333790 abstract "Abstract There have been no reports on an abundance of CD4−8−B220+ αβ T cells, seen in autoimmune mice carrying the lpr gene (abnormal Fas gene), in any immune organs of normal mice. We herein report, however, that such αβ T cells were abundant at intraepithelial sites of the appendix in normal mice. They lacked the expression of NK1.1 Ags (C57BL/6 mice), but had the morphology of granular lymphocytes and contained forbidden T cell clones in the minor lymphocyte-stimulating antigen (Mls) system (C3H/He mice with Mls-1b2a). In other words, many properties of intraepithelial T cells in the appendix resembled those ascribed to abnormal αβ T cells, which expand in the lymph nodes and spleen of lpr mice. In the case of lpr mice, CD4−8−B220+ αβ T cells first expanded in the appendix and then extended to other organs. CD4−8−B220+ αβ T cells seemed to originate in situ from c-kit+ stem cells in the appendix. These results suggest that the appendix is one of the primary sites in which CD4−8−B220+ αβ T cells exist, and that these cells carry many primordial properties as prototype T cells." @default.
• W4313333790 created "2023-01-06" @default.
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• W4313333790 date "1998-03-15" @default.
• W4313333790 modified "2023-10-11" @default.
• W4313333790 title "The Primary Site of CD4−8−B220+ αβ T Cells in<i>lpr</i>Mice: The Appendix in Normal Mice" @default.
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• W4313333790 doi "https://doi.org/10.4049/jimmunol.160.6.2665" @default.
• W4313333790 hasPublicationYear "1998" @default.
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