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- W4313333793 abstract "Abstract The tissue- and stage-specific assembly of Ag receptor genes is regulated by transcriptional control elements positioned within Ig and TCR loci. To further understand the role of cis-acting elements in these regulatory mechanisms, we have characterized a transcriptional promoter that drives germline expression of TCRβ gene segments in vivo. The activity of this promoter, termed PDβ, is restricted to a highly conserved 400-bp region located directly upstream from Dβ1-coding sequences. Maximal PDβ activity requires a TATA element situated within the Dβ1 recombination signal sequences and consensus binding sites for the ubiquitous SP1 and the T cell-specific GATA-3 transcription factors. When linked to active enhancer elements, PDβ directs transcription in most cell types; however, the TCRβ enhancer (Eβ) stimulates PDβ function specifically in precursor T lymphocytes. These findings suggest that PDβ/Eβ interactions may contribute to differential regulation of regions within the TCRβ locus during thymocyte development." @default.
- W4313333793 created "2023-01-06" @default.
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- W4313333793 date "1998-08-01" @default.
- W4313333793 modified "2023-10-17" @default.
- W4313333793 title "A Developmental Stage-Specific Promoter Directs Germline Transcription of DβJβ Gene Segments in Precursor T Lymphocytes" @default.
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- W4313333793 doi "https://doi.org/10.4049/jimmunol.161.3.1399" @default.
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