FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333847> ?p ?o ?g. }

• W4313333847 endingPage "3055" @default.
• W4313333847 startingPage "3048" @default.
• W4313333847 abstract "Abstract Despite the enormous potential repertoire of γδ T cells, there are several observations which suggest that the expressed γδ repertoire in the periphery of normal individuals is often quite restricted. To assess selective expansions among γδ T cells from both adult and newborn blood samples, PBMC from 12 normal adults and cord blood from 15 normal newborns were analyzed for TCRDV1 and TCRDV2 junctional diversity by CDR3 size spectratyping and single-strand conformational polymorphism. Although TCRBV usage showed extensive heterogeneity in adults and newborns, both populations often showed CDR3 region restriction for TCRDV1 and TCRDV2. Analysis of the CDR3 spectratype patterns of newborn twins suggested that clonal selection for TCRDV is independent of genetic background. The possible role of Gram-negative bacteria in driving selective responsiveness of γδ T cells in PBMCs from adults was examined by in vitro stimulation with Escherichia coli and Pseudomonas aeruginosa. Donors whose TCRDV repertoire was highly clonal in the unstimulated blood cells showed the same predominant clones among the bacteria-stimulated cultures. In individuals whose γδ T cells were less restricted, in vitro stimulation did not select for clonality; rather, the TCRDV repertoires were similar before and after bacterial stimulation. Together, these data indicate that γδ T cells are often clonally restricted in adults as well as in newborns and suggest that the prominent stimulatory activity of Gram-negative bacteria does not by itself account for the restriction or diversity of the γδ T cell repertoire." @default.
• W4313333847 created "2023-01-06" @default.
• W4313333847 creator A5001528578 @default.
• W4313333847 creator A5020327827 @default.
• W4313333847 creator A5044368799 @default.
• W4313333847 creator A5044850321 @default.
• W4313333847 creator A5060110033 @default.
• W4313333847 creator A5069407048 @default.
• W4313333847 creator A5081616565 @default.
• W4313333847 date "1998-03-15" @default.
• W4313333847 modified "2023-10-14" @default.
• W4313333847 title "Oligoclonality of Vδ1 and Vδ2 Cells in Human Peripheral Blood Mononuclear Cells: TCR Selection Is Not Altered by Stimulation with Gram-Negative Bacteria" @default.
• W4313333847 cites W1533396898 @default.
• W4313333847 cites W1574496133 @default.
• W4313333847 cites W1600714133 @default.
• W4313333847 cites W1605156330 @default.
• W4313333847 cites W1656113025 @default.
• W4313333847 cites W1732006940 @default.
• W4313333847 cites W1893562367 @default.
• W4313333847 cites W1932492060 @default.
• W4313333847 cites W1987815433 @default.
• W4313333847 cites W1991447695 @default.
• W4313333847 cites W1992016218 @default.
• W4313333847 cites W1996027687 @default.
• W4313333847 cites W1997136314 @default.
• W4313333847 cites W1999431134 @default.
• W4313333847 cites W2011586685 @default.
• W4313333847 cites W2016403646 @default.
• W4313333847 cites W2036972639 @default.
• W4313333847 cites W2037268137 @default.
• W4313333847 cites W2046950882 @default.
• W4313333847 cites W2050846815 @default.
• W4313333847 cites W2078728841 @default.
• W4313333847 cites W2087133492 @default.
• W4313333847 cites W2089805317 @default.
• W4313333847 cites W2093910980 @default.
• W4313333847 cites W2096390098 @default.
• W4313333847 cites W2100939719 @default.
• W4313333847 cites W2111261715 @default.
• W4313333847 cites W2115962706 @default.
• W4313333847 cites W2120695405 @default.
• W4313333847 cites W2145065705 @default.
• W4313333847 cites W2147659250 @default.
• W4313333847 cites W2153901715 @default.
• W4313333847 cites W2301118487 @default.
• W4313333847 cites W4365410999 @default.
• W4313333847 cites W2108574795 @default.
• W4313333847 doi "https://doi.org/10.4049/jimmunol.160.6.3048" @default.
• W4313333847 hasPublicationYear "1998" @default.
• W4313333847 type Work @default.
• W4313333847 citedByCount "12" @default.
• W4313333847 countsByYear W43133338472012 @default.
• W4313333847 crossrefType "journal-article" @default.
• W4313333847 hasAuthorship W4313333847A5001528578 @default.
• W4313333847 hasAuthorship W4313333847A5020327827 @default.
• W4313333847 hasAuthorship W4313333847A5044368799 @default.
• W4313333847 hasAuthorship W4313333847A5044850321 @default.
• W4313333847 hasAuthorship W4313333847A5060110033 @default.
• W4313333847 hasAuthorship W4313333847A5069407048 @default.
• W4313333847 hasAuthorship W4313333847A5081616565 @default.
• W4313333847 hasBestOaLocation W43133338471 @default.
• W4313333847 hasConcept C104317684 @default.
• W4313333847 hasConcept C121332964 @default.
• W4313333847 hasConcept C137061746 @default.
• W4313333847 hasConcept C141231307 @default.
• W4313333847 hasConcept C147483822 @default.
• W4313333847 hasConcept C169760540 @default.
• W4313333847 hasConcept C19317047 @default.
• W4313333847 hasConcept C202751555 @default.
• W4313333847 hasConcept C203014093 @default.
• W4313333847 hasConcept C24890656 @default.
• W4313333847 hasConcept C24998067 @default.
• W4313333847 hasConcept C2776090121 @default.
• W4313333847 hasConcept C2778473898 @default.
• W4313333847 hasConcept C36333154 @default.
• W4313333847 hasConcept C54355233 @default.
• W4313333847 hasConcept C7386963 @default.
• W4313333847 hasConcept C86803240 @default.
• W4313333847 hasConcept C8891405 @default.
• W4313333847 hasConcept C89423630 @default.
• W4313333847 hasConceptScore W4313333847C104317684 @default.
• W4313333847 hasConceptScore W4313333847C121332964 @default.
• W4313333847 hasConceptScore W4313333847C137061746 @default.
• W4313333847 hasConceptScore W4313333847C141231307 @default.
• W4313333847 hasConceptScore W4313333847C147483822 @default.
• W4313333847 hasConceptScore W4313333847C169760540 @default.
• W4313333847 hasConceptScore W4313333847C19317047 @default.
• W4313333847 hasConceptScore W4313333847C202751555 @default.
• W4313333847 hasConceptScore W4313333847C203014093 @default.
• W4313333847 hasConceptScore W4313333847C24890656 @default.
• W4313333847 hasConceptScore W4313333847C24998067 @default.
• W4313333847 hasConceptScore W4313333847C2776090121 @default.
• W4313333847 hasConceptScore W4313333847C2778473898 @default.
• W4313333847 hasConceptScore W4313333847C36333154 @default.
• W4313333847 hasConceptScore W4313333847C54355233 @default.
• W4313333847 hasConceptScore W4313333847C7386963 @default.
• W4313333847 hasConceptScore W4313333847C86803240 @default.
• W4313333847 hasConceptScore W4313333847C8891405 @default.

• next