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- W4313333862 abstract "Abstract Mice lacking the common cytokine receptor γ-chain (γc) gene exhibit defective development of NK cells and CD8+ T cells and greatly diminished production of IFN-γ. Because resistance of SCID mice to Toxoplasma gondii requires IL-12-dependent IFN-γ production by NK cells, we expected that γc-deficient mice would succumb rapidly to the parasite. Surprisingly, however, most γc-deficient mice survived the acute phase of T. gondii infection. As in wild-type mice, this resistance required IL-12 and IFN-γ; nevertheless, whereas wild-type mice depleted of CD4+ T cells survived, anti-CD4+ treated γc-deficient mice displayed diminished production of IFN-γ and all succumbed to acute infection. These data not only reveal a role for CD4+ T lymphocytes in IFN-γ-dependent host defense but also establish SCID and γc-deficient mice as powerful complementary tools for assessing the function of NK vs CD4+ T cells in immunopathophysiologic responses." @default.
- W4313333862 created "2023-01-06" @default.
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- W4313333862 date "1998-03-15" @default.
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- W4313333862 title "Cutting Edge: Infection of Mice Lacking the Common Cytokine Receptor γ-Chain (γc) Reveals an Unexpected Role for CD4+ T Lymphocytes in Early IFN-γ-Dependent Resistance to<i>Toxoplasma gondii</i>" @default.
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- W4313333862 doi "https://doi.org/10.4049/jimmunol.160.6.2565" @default.
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