FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313333887> ?p ?o ?g. }

• W4313333887 endingPage "121277" @default.
• W4313333887 startingPage "121277" @default.
• W4313333887 abstract "Prostaglandin E2 (PGE2) is a lipid hormone that signals through 4 different G-protein coupled receptor subtypes which act to regulate key physiological processes. Our laboratory has previously reported that PGE2 through its EP3 receptor reduces cardiac contractility at the level of isolated cardiomyocytes and in the isolated working heart preparation. We therefore hypothesized that cardiomyocyte specific overexpression of the PGE2 EP3 receptor further decreases cardiac function in a mouse model of heart failure produced by myocardial infarction. Our study tested this hypothesis using EP3 transgenic mice (EP3 TG), which overexpress the porcine analogue of human EP3 in the cardiomyocytes, and their wildtype (WT) littermates. Mice were analyzed 2 wks after myocardial infarction (MI) or sham operation by echocardiography, RT-PCR, immunohistochemistry, and histology. We found that the EP3 TG sham controls had a reduced ejection fraction, reduced fractional shortening, and an increased left ventricular dimension at systole and diastole compared to the WT sham controls. Moreover, there was a further reduction in the EP3 TG mice after myocardial infarction. Additionally, single-cell analysis of cardiomyocytes isolated from EP3 TG mice showed reduced contractility under basal conditions. Overexpression of EP3 significantly increased cardiac hypertrophy, interstitial collagen fraction, macrophage, and T-cell infiltration in the sham operated group. Interestingly, after MI, there were no changes in hypertrophy but there were changes in collagen fraction, and inflammatory cell infiltration. Overexpression of EP3 reduces cardiac function under basal conditions and this is exacerbated after myocardial infarction." @default.
• W4313333887 created "2023-01-06" @default.
• W4313333887 creator A5015800022 @default.
• W4313333887 creator A5025809485 @default.
• W4313333887 creator A5025970596 @default.
• W4313333887 creator A5061439030 @default.
• W4313333887 creator A5062803492 @default.
• W4313333887 creator A5091584403 @default.
• W4313333887 date "2023-01-01" @default.
• W4313333887 modified "2023-09-27" @default.
• W4313333887 title "Deleterious effects of cardiomyocyte-specific prostaglandin E2 EP3 receptor overexpression on cardiac function after myocardial infarction" @default.
• W4313333887 cites W1574722738 @default.
• W4313333887 cites W1963606632 @default.
• W4313333887 cites W1965638288 @default.
• W4313333887 cites W1972002670 @default.
• W4313333887 cites W1984199239 @default.
• W4313333887 cites W1992324970 @default.
• W4313333887 cites W1994714063 @default.
• W4313333887 cites W2011466028 @default.
• W4313333887 cites W2023800627 @default.
• W4313333887 cites W2058755393 @default.
• W4313333887 cites W2060123811 @default.
• W4313333887 cites W2085698001 @default.
• W4313333887 cites W2096442966 @default.
• W4313333887 cites W2098668436 @default.
• W4313333887 cites W2110869761 @default.
• W4313333887 cites W2116599908 @default.
• W4313333887 cites W2128902566 @default.
• W4313333887 cites W2134063706 @default.
• W4313333887 cites W2143425349 @default.
• W4313333887 cites W2146936491 @default.
• W4313333887 cites W2234337144 @default.
• W4313333887 cites W2293932042 @default.
• W4313333887 cites W2518952462 @default.
• W4313333887 cites W2548152158 @default.
• W4313333887 cites W2772240339 @default.
• W4313333887 cites W2772805131 @default.
• W4313333887 cites W2791392198 @default.
• W4313333887 cites W2791584533 @default.
• W4313333887 cites W2904790460 @default.
• W4313333887 cites W2977840055 @default.
• W4313333887 cites W3009505437 @default.
• W4313333887 cites W3014673046 @default.
• W4313333887 cites W3215841876 @default.
• W4313333887 cites W4223471203 @default.
• W4313333887 cites W49841745 @default.
• W4313333887 doi "https://doi.org/10.1016/j.lfs.2022.121277" @default.
• W4313333887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36521546" @default.
• W4313333887 hasPublicationYear "2023" @default.
• W4313333887 type Work @default.
• W4313333887 citedByCount "1" @default.
• W4313333887 countsByYear W43133338872023 @default.
• W4313333887 crossrefType "journal-article" @default.
• W4313333887 hasAuthorship W4313333887A5015800022 @default.
• W4313333887 hasAuthorship W4313333887A5025809485 @default.
• W4313333887 hasAuthorship W4313333887A5025970596 @default.
• W4313333887 hasAuthorship W4313333887A5061439030 @default.
• W4313333887 hasAuthorship W4313333887A5062803492 @default.
• W4313333887 hasAuthorship W4313333887A5091584403 @default.
• W4313333887 hasBestOaLocation W43133338871 @default.
• W4313333887 hasConcept C111566952 @default.
• W4313333887 hasConcept C126322002 @default.
• W4313333887 hasConcept C134018914 @default.
• W4313333887 hasConcept C164705383 @default.
• W4313333887 hasConcept C167414201 @default.
• W4313333887 hasConcept C170493617 @default.
• W4313333887 hasConcept C207200792 @default.
• W4313333887 hasConcept C2778198053 @default.
• W4313333887 hasConcept C2779537366 @default.
• W4313333887 hasConcept C2780664492 @default.
• W4313333887 hasConcept C39133596 @default.
• W4313333887 hasConcept C500558357 @default.
• W4313333887 hasConcept C71924100 @default.
• W4313333887 hasConcept C78085059 @default.
• W4313333887 hasConceptScore W4313333887C111566952 @default.
• W4313333887 hasConceptScore W4313333887C126322002 @default.
• W4313333887 hasConceptScore W4313333887C134018914 @default.
• W4313333887 hasConceptScore W4313333887C164705383 @default.
• W4313333887 hasConceptScore W4313333887C167414201 @default.
• W4313333887 hasConceptScore W4313333887C170493617 @default.
• W4313333887 hasConceptScore W4313333887C207200792 @default.
• W4313333887 hasConceptScore W4313333887C2778198053 @default.
• W4313333887 hasConceptScore W4313333887C2779537366 @default.
• W4313333887 hasConceptScore W4313333887C2780664492 @default.
• W4313333887 hasConceptScore W4313333887C39133596 @default.
• W4313333887 hasConceptScore W4313333887C500558357 @default.
• W4313333887 hasConceptScore W4313333887C71924100 @default.
• W4313333887 hasConceptScore W4313333887C78085059 @default.
• W4313333887 hasFunder F4320332161 @default.
• W4313333887 hasLocation W43133338871 @default.
• W4313333887 hasLocation W43133338872 @default.
• W4313333887 hasOpenAccess W4313333887 @default.
• W4313333887 hasPrimaryLocation W43133338871 @default.
• W4313333887 hasRelatedWork W2068259322 @default.
• W4313333887 hasRelatedWork W2088188662 @default.
• W4313333887 hasRelatedWork W2359117289 @default.
• W4313333887 hasRelatedWork W2363366439 @default.
• W4313333887 hasRelatedWork W2375703560 @default.

• next