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- W4313334384 abstract "Transcutaneous auricular vagus nerve stimulation (taVNS) is a neurostimulatory technique hypothesised to enhance central noradrenaline. Currently, there is scarce evidence in support of a noradrenergic mechanism of taVNS and limited knowledge on its stimulation parameters (i.e., intensity and pulse width). Therefore, the present study aimed to test whether taVNS enhances pupil dilation, a noradrenergic biomarker, as a function of stimulation parameters. Forty-nine participants received sham (i.e., left ear earlobe) and taVNS (i.e., left ear cymba concha) stimulation in two separate sessions, in a counterbalanced order. We administered short bursts (5s) of seven stimulation settings varying as a function of pulse width and intensity and measured pupil size in parallel. Each stimulation setting was administered sixteen times in separate blocks. We expected short bursts of stimulation to elicit phasic noradrenergic activity as indexed by event-related pupil dilation and event-related temporal derivative. We hypothesised higher stimulation settings, quantified as the total charge per pulse (pulse width x intensity), to drive greater event-related pupil dilation and temporal derivative in the taVNS compared to sham condition. Specifically, we expected stimulation settings in the taVNS condition to be associated with a linear increase in event-related pupil dilation and temporal derivative. We found stimulation settings to linearly increase both pupil measures. In line with our hypothesis, the observed dose-dependent effect was stronger in the taVNS condition. We also found taVNS to elicit more intense and unpleasant sensations than sham stimulation. These results support the hypothesis of a noradrenergic mechanism of taVNS. However, future studies should disentangle whether stimulation elicited sensations mediate the effect of taVNS on evoked pupil dilation." @default.
- W4313334384 created "2023-01-06" @default.
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- W4313334384 date "2023-02-01" @default.
- W4313334384 modified "2023-10-16" @default.
- W4313334384 title "Short bursts of transcutaneous auricular vagus nerve stimulation enhance evoked pupil dilation as a function of stimulation parameters" @default.
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- W4313334384 cites W1932385070 @default.
- W4313334384 cites W1967022536 @default.
- W4313334384 cites W1984796586 @default.
- W4313334384 cites W1985733673 @default.
- W4313334384 cites W1997095235 @default.
- W4313334384 cites W2010752391 @default.
- W4313334384 cites W2011336106 @default.
- W4313334384 cites W2012640962 @default.
- W4313334384 cites W2013313898 @default.
- W4313334384 cites W2015473291 @default.
- W4313334384 cites W2017146523 @default.
- W4313334384 cites W2019361862 @default.
- W4313334384 cites W2019655958 @default.
- W4313334384 cites W2045277530 @default.
- W4313334384 cites W2052594619 @default.
- W4313334384 cites W2062503636 @default.
- W4313334384 cites W2064612198 @default.
- W4313334384 cites W2078790407 @default.
- W4313334384 cites W2089763487 @default.
- W4313334384 cites W2091732895 @default.
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- W4313334384 cites W2115212197 @default.
- W4313334384 cites W2117104656 @default.
- W4313334384 cites W2117555599 @default.
- W4313334384 cites W2124304098 @default.
- W4313334384 cites W2135537366 @default.
- W4313334384 cites W2143683595 @default.
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- W4313334384 cites W2167557160 @default.
- W4313334384 cites W2200917453 @default.
- W4313334384 cites W2205637517 @default.
- W4313334384 cites W2210396547 @default.
- W4313334384 cites W2211884092 @default.
- W4313334384 cites W2408132364 @default.
- W4313334384 cites W2530389148 @default.
- W4313334384 cites W2538195819 @default.
- W4313334384 cites W2551360963 @default.
- W4313334384 cites W2559518379 @default.
- W4313334384 cites W2564149303 @default.
- W4313334384 cites W2585805409 @default.
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- W4313334384 cites W2808872446 @default.
- W4313334384 cites W2809321748 @default.
- W4313334384 cites W2884094204 @default.
- W4313334384 cites W2888348079 @default.
- W4313334384 cites W2893033360 @default.
- W4313334384 cites W2904654527 @default.
- W4313334384 cites W2913606428 @default.
- W4313334384 cites W2966375437 @default.
- W4313334384 cites W2980505750 @default.
- W4313334384 cites W3001557906 @default.
- W4313334384 cites W3004809941 @default.
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- W4313334384 cites W3039906298 @default.
- W4313334384 cites W3119404404 @default.
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- W4313334384 cites W3159705451 @default.
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- W4313334384 doi "https://doi.org/10.1016/j.cortex.2022.11.012" @default.
- W4313334384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640622" @default.
- W4313334384 hasPublicationYear "2023" @default.
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