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- W4313334574 endingPage "100771" @default.
- W4313334574 startingPage "100771" @default.
- W4313334574 abstract "Current treatments for advanced hepatocellular carcinoma (HCC) have limited success in improving patients’ quality of life and prolonging life expectancy. The clinical need for more efficient and safe therapies has contributed to the exploration of emerging strategies. Recently, there has been increased interest in oncolytic viruses (OVs) as a therapeutic modality for HCC. OVs undergo selective replication in cancerous tissues and kill tumor cells. Strikingly, pexastimogene devacirepvec (Pexa-Vec) was granted an orphan drug status in HCC by the U.S. Food and Drug Administration (FDA) in 2013. Meanwhile, dozens of OVs are being tested in HCC-directed clinical and preclinical trials. In this review, the pathogenesis and current therapies of HCC are outlined. Next, we summarize multiple OVs as single therapeutic agents for the treatment of HCC, which have demonstrated certain efficacy and low toxicity. Emerging carrier cell-, bioengineered cell mimetic- or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are described. In addition, we highlight the combination treatments between oncolytic virotherapy and other modalities. Finally, the clinical challenges and prospects of OV-based biotherapy are discussed, with the aim of continuing to develop a fascinating approach in HCC patients." @default.
- W4313334574 created "2023-01-06" @default.
- W4313334574 creator A5048704738 @default.
- W4313334574 creator A5049036463 @default.
- W4313334574 creator A5062111707 @default.
- W4313334574 creator A5080532670 @default.
- W4313334574 creator A5084762209 @default.
- W4313334574 date "2023-01-01" @default.
- W4313334574 modified "2023-10-01" @default.
- W4313334574 title "Oncolytic virus-based hepatocellular carcinoma treatment: Current status, intravenous delivery strategies, and emerging combination therapeutic solutions" @default.
- W4313334574 cites W1541576635 @default.
- W4313334574 cites W1549566105 @default.
- W4313334574 cites W1773821183 @default.
- W4313334574 cites W1799522345 @default.
- W4313334574 cites W1965623612 @default.
- W4313334574 cites W1988967544 @default.
- W4313334574 cites W2002222434 @default.
- W4313334574 cites W2008553086 @default.
- W4313334574 cites W2015720380 @default.
- W4313334574 cites W2016080258 @default.
- W4313334574 cites W2017614842 @default.
- W4313334574 cites W2021409536 @default.
- W4313334574 cites W2022066273 @default.
- W4313334574 cites W2025371271 @default.
- W4313334574 cites W2026486274 @default.
- W4313334574 cites W2033802014 @default.
- W4313334574 cites W2036044673 @default.
- W4313334574 cites W2037497526 @default.
- W4313334574 cites W2041935553 @default.
- W4313334574 cites W2052617606 @default.
- W4313334574 cites W2052670052 @default.
- W4313334574 cites W2052758181 @default.
- W4313334574 cites W2060469376 @default.
- W4313334574 cites W2063924821 @default.
- W4313334574 cites W2069839007 @default.
- W4313334574 cites W2071456955 @default.
- W4313334574 cites W2077302131 @default.
- W4313334574 cites W2093059993 @default.
- W4313334574 cites W2099657378 @default.
- W4313334574 cites W2101058247 @default.
- W4313334574 cites W2106265979 @default.
- W4313334574 cites W2107748384 @default.
- W4313334574 cites W2121605579 @default.
- W4313334574 cites W2123541316 @default.
- W4313334574 cites W2123834804 @default.
- W4313334574 cites W2125426944 @default.
- W4313334574 cites W2126308189 @default.
- W4313334574 cites W2127313936 @default.
- W4313334574 cites W2131132108 @default.
- W4313334574 cites W2138603110 @default.
- W4313334574 cites W2139397653 @default.
- W4313334574 cites W2140997748 @default.
- W4313334574 cites W2142639029 @default.
- W4313334574 cites W2143022774 @default.
- W4313334574 cites W2156119394 @default.
- W4313334574 cites W2159999899 @default.
- W4313334574 cites W2167451108 @default.
- W4313334574 cites W2209331389 @default.
- W4313334574 cites W2332574321 @default.
- W4313334574 cites W2346290557 @default.
- W4313334574 cites W2442772249 @default.
- W4313334574 cites W2462248378 @default.
- W4313334574 cites W2497822529 @default.
- W4313334574 cites W2508708811 @default.
- W4313334574 cites W2510078407 @default.
- W4313334574 cites W2514880479 @default.
- W4313334574 cites W2547101205 @default.
- W4313334574 cites W2549345277 @default.
- W4313334574 cites W2554054889 @default.
- W4313334574 cites W2587142197 @default.
- W4313334574 cites W2605477612 @default.
- W4313334574 cites W2605532397 @default.
- W4313334574 cites W2605606775 @default.
- W4313334574 cites W2620424811 @default.
- W4313334574 cites W2664203916 @default.
- W4313334574 cites W2751781206 @default.
- W4313334574 cites W2755866843 @default.
- W4313334574 cites W2765408594 @default.
- W4313334574 cites W2766034749 @default.
- W4313334574 cites W2776363019 @default.
- W4313334574 cites W2776551433 @default.
- W4313334574 cites W2780569879 @default.
- W4313334574 cites W2788210656 @default.
- W4313334574 cites W2788499428 @default.
- W4313334574 cites W2796643083 @default.
- W4313334574 cites W2796687534 @default.
- W4313334574 cites W2800204540 @default.
- W4313334574 cites W2801067660 @default.
- W4313334574 cites W2801821552 @default.
- W4313334574 cites W2884815522 @default.
- W4313334574 cites W2889646458 @default.
- W4313334574 cites W2889777194 @default.
- W4313334574 cites W2899780553 @default.
- W4313334574 cites W2908243278 @default.
- W4313334574 cites W2915903915 @default.
- W4313334574 cites W2919987102 @default.
- W4313334574 cites W2920256884 @default.
- W4313334574 cites W2921466970 @default.