FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313334710> ?p ?o ?g. }

• W4313334710 endingPage "109" @default.
• W4313334710 startingPage "102" @default.
• W4313334710 abstract "Local ablative treatment (LAT) is increasingly combined with systemic therapy in oligometastatic breast cancer (OMBC), without a high-level evidence to support this strategy. We evaluated the addition of LAT to systemic treatment in terms of progression-free survival (PFS) and overall survival (OS). Secondary endpoints were local control (LC) and toxicity. We sought to identify prognostic factors associated with longer OS and PFS.We identified consecutive patients treated between 2014 and 2018 for synchronous or metachronous OMBC (defined as ≤ 5 metastases). LAT included stereotactic body radiation therapy (SBRT) and volumetric modulated arc therapy (VMAT), surgery, cryotherapy and percutaneous radiofrequency ablation (PRA). PFS and OS were calculated, and Cox regression models analyzed for potential predictors of survival.One hundred two patients were included (no-LAT, n = 62; LAT, n = 40). Sixty-four metastases received LAT. Median follow-up was 50.4 months (95% CI [44.4; 53.4]). One patient experienced grade 3 toxicity in the LAT group. Five-year PFS and OS were 34.75% (95% CI [24.42-45.26]) and 63.21% (95% CI [50.69-73.37]) respectively. Patients receiving both LAT and systemic therapy had longer PFS and OS than those with no-LAT ([HR 0.39, p = 0.002]) and ([HR 0.31, p = 0.01]). The use of LAT, HER2-positive status and hormone-receptor positivity were associated with longer PFS and OS whereas liver metastases led to worse PFS.LAT was associated with improved outcomes in OMBC when added to systemic treatment, without significantly increasing toxicity. The prognostic factors identified to extend PFS and OS may help guide clinicians in selecting patients for LAT." @default.
• W4313334710 created "2023-01-06" @default.
• W4313334710 creator A5007855942 @default.
• W4313334710 creator A5010896487 @default.
• W4313334710 creator A5012104919 @default.
• W4313334710 creator A5013738349 @default.
• W4313334710 creator A5029498267 @default.
• W4313334710 creator A5031969657 @default.
• W4313334710 creator A5046841549 @default.
• W4313334710 creator A5050162604 @default.
• W4313334710 creator A5057100466 @default.
• W4313334710 creator A5058791215 @default.
• W4313334710 creator A5069496453 @default.
• W4313334710 creator A5070308228 @default.
• W4313334710 creator A5089271242 @default.
• W4313334710 creator A5090902015 @default.
• W4313334710 date "2023-02-01" @default.
• W4313334710 modified "2023-09-30" @default.
• W4313334710 title "Systemic treatment with or without ablative therapies in oligometastatic breast cancer: A single institution analysis of patient outcomes" @default.
• W4313334710 cites W1891116330 @default.
• W4313334710 cites W2019607817 @default.
• W4313334710 cites W2023445800 @default.
• W4313334710 cites W2122164580 @default.
• W4313334710 cites W2136739052 @default.
• W4313334710 cites W2148754315 @default.
• W4313334710 cites W2151252396 @default.
• W4313334710 cites W2160166879 @default.
• W4313334710 cites W2164621703 @default.
• W4313334710 cites W2200014587 @default.
• W4313334710 cites W2239021931 @default.
• W4313334710 cites W2345921505 @default.
• W4313334710 cites W2552099557 @default.
• W4313334710 cites W2560635244 @default.
• W4313334710 cites W2587542271 @default.
• W4313334710 cites W2758911710 @default.
• W4313334710 cites W2760672016 @default.
• W4313334710 cites W2783886889 @default.
• W4313334710 cites W2907948157 @default.
• W4313334710 cites W2939770857 @default.
• W4313334710 cites W2983766010 @default.
• W4313334710 cites W2997721110 @default.
• W4313334710 cites W3019546741 @default.
• W4313334710 cites W3035374677 @default.
• W4313334710 cites W3043128098 @default.
• W4313334710 cites W3085367132 @default.
• W4313334710 cites W3094325343 @default.
• W4313334710 cites W3108524044 @default.
• W4313334710 cites W3128619662 @default.
• W4313334710 cites W3156856783 @default.
• W4313334710 cites W3169205666 @default.
• W4313334710 cites W3181603733 @default.
• W4313334710 cites W3195714239 @default.
• W4313334710 cites W3202552190 @default.
• W4313334710 cites W4206666777 @default.
• W4313334710 cites W4223542486 @default.
• W4313334710 cites W4231096603 @default.
• W4313334710 cites W4240340450 @default.
• W4313334710 cites W4286510380 @default.
• W4313334710 doi "https://doi.org/10.1016/j.breast.2022.12.035" @default.
• W4313334710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36709639" @default.
• W4313334710 hasPublicationYear "2023" @default.
• W4313334710 type Work @default.
• W4313334710 citedByCount "4" @default.
• W4313334710 countsByYear W43133347102023 @default.
• W4313334710 crossrefType "journal-article" @default.
• W4313334710 hasAuthorship W4313334710A5007855942 @default.
• W4313334710 hasAuthorship W4313334710A5010896487 @default.
• W4313334710 hasAuthorship W4313334710A5012104919 @default.
• W4313334710 hasAuthorship W4313334710A5013738349 @default.
• W4313334710 hasAuthorship W4313334710A5029498267 @default.
• W4313334710 hasAuthorship W4313334710A5031969657 @default.
• W4313334710 hasAuthorship W4313334710A5046841549 @default.
• W4313334710 hasAuthorship W4313334710A5050162604 @default.
• W4313334710 hasAuthorship W4313334710A5057100466 @default.
• W4313334710 hasAuthorship W4313334710A5058791215 @default.
• W4313334710 hasAuthorship W4313334710A5069496453 @default.
• W4313334710 hasAuthorship W4313334710A5070308228 @default.
• W4313334710 hasAuthorship W4313334710A5089271242 @default.
• W4313334710 hasAuthorship W4313334710A5090902015 @default.
• W4313334710 hasBestOaLocation W43133347101 @default.
• W4313334710 hasConcept C121608353 @default.
• W4313334710 hasConcept C126322002 @default.
• W4313334710 hasConcept C141071460 @default.
• W4313334710 hasConcept C143998085 @default.
• W4313334710 hasConcept C185926286 @default.
• W4313334710 hasConcept C19617505 @default.
• W4313334710 hasConcept C2776694085 @default.
• W4313334710 hasConcept C2777377203 @default.
• W4313334710 hasConcept C2778902805 @default.
• W4313334710 hasConcept C2780149145 @default.
• W4313334710 hasConcept C2780387249 @default.
• W4313334710 hasConcept C2780739268 @default.
• W4313334710 hasConcept C29730261 @default.
• W4313334710 hasConcept C50382708 @default.
• W4313334710 hasConcept C509974204 @default.
• W4313334710 hasConcept C530470458 @default.
• W4313334710 hasConcept C71924100 @default.
• W4313334710 hasConceptScore W4313334710C121608353 @default.

• next