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- W4313334826 abstract "The transcription factor p53 suppresses tumorigenesis via a wide-ranging, concerted set of functions. Although several studies have identified cytoplasmic, transcription-independent functions of p53, the biological relevance of these activities has not been fully elucidated, particularly in vivo. Here, we generated a mouse model with a p53K316P mutation, which mimics a naturally occurring p53 nuclear localization signal (NLS) change observed in bat species. We find that the p53K316P mutation increases cytoplasmic localization of p53 and promotes a pleiotropic metabolic phenotype that includes increased adiposity, increased de novo lipogenesis, and decreased lactate generation. Mechanistic studies show that, independent of its transactivation function, p53K316P interacts with lactate dehydrogenase B (LDHB) and alters the composition and enzymatic activities of LDH complex favoring pyruvate generation and hindering lactate production. Overall, the study identifies a role for cytoplasmic p53 in the regulation of metabolism that favors energy generation and storage." @default.
- W4313334826 created "2023-01-06" @default.
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- W4313334826 date "2023-01-01" @default.
- W4313334826 modified "2023-09-29" @default.
- W4313334826 title "A role of cytoplasmic p53 in the regulation of metabolism shown by bat-mimicking p53 NLS mutant mice" @default.
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- W4313334826 doi "https://doi.org/10.1016/j.celrep.2022.111920" @default.
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