Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335044> ?p ?o ?g. }
- W4313335044 endingPage "674" @default.
- W4313335044 startingPage "668" @default.
- W4313335044 abstract "Abstract In the CNS, astrocytes play a key role in immunological and inflammatory responses through ICAM-1 expression, cytokine secretion (including TNF-α), and regulation of blood-brain barrier permeability. Because ICAM-1 transduces intracellular signals in lymphocytes and endothelial cells, we investigated in the present study ICAM-1-coupled signaling pathways in astrocytes. Using rat astrocytes in culture, we report that ICAM-1 binding by specific Abs induces TNF-α secretion together with phosphorylation of the transcription factor cAMP response element-binding protein. We show that ICAM-1 binding induces cAMP accumulation and activation of the mitogen-activated protein kinase extracellular signal-regulated kinase. Both pathways are responsible for cAMP response element-binding protein phosphorylation and TNF-α secretion. Moreover, these responses are partially dependent protein kinase C, which acts indirectly, as a common activator of cAMP/protein kinase A and extracellular signal-regulated kinase pathways. These results constitute the first evidence of ICAM-1 coupling to intracellular signaling pathways in glial cells and demonstrate the convergence of these pathways onto transcription factor regulation and TNF-α secretion. They strongly suggest that ICAM-1-dependent cellular adhesion to astrocytes could contribute to the inflammatory processes observed during leukocyte infiltration in the CNS." @default.
- W4313335044 created "2023-01-06" @default.
- W4313335044 creator A5010409179 @default.
- W4313335044 creator A5025747144 @default.
- W4313335044 creator A5036072797 @default.
- W4313335044 creator A5081410860 @default.
- W4313335044 date "1999-07-15" @default.
- W4313335044 modified "2023-10-17" @default.
- W4313335044 title "ICAM-1-Coupled Signaling Pathways in Astrocytes Converge to Cyclic AMP Response Element-Binding Protein Phosphorylation and TNF-α Secretion" @default.
- W4313335044 cites W1487293721 @default.
- W4313335044 cites W1494401713 @default.
- W4313335044 cites W1511268390 @default.
- W4313335044 cites W1526791546 @default.
- W4313335044 cites W1530203607 @default.
- W4313335044 cites W1542795408 @default.
- W4313335044 cites W1577796071 @default.
- W4313335044 cites W1590540783 @default.
- W4313335044 cites W1594394126 @default.
- W4313335044 cites W1755902553 @default.
- W4313335044 cites W1966088318 @default.
- W4313335044 cites W1973135307 @default.
- W4313335044 cites W1975444882 @default.
- W4313335044 cites W1978409115 @default.
- W4313335044 cites W1981513372 @default.
- W4313335044 cites W1991121223 @default.
- W4313335044 cites W1998872974 @default.
- W4313335044 cites W2001895687 @default.
- W4313335044 cites W2005701667 @default.
- W4313335044 cites W2027831195 @default.
- W4313335044 cites W2028102872 @default.
- W4313335044 cites W2028242823 @default.
- W4313335044 cites W2033529039 @default.
- W4313335044 cites W2035936653 @default.
- W4313335044 cites W2043183468 @default.
- W4313335044 cites W2043856037 @default.
- W4313335044 cites W2053993475 @default.
- W4313335044 cites W2054473433 @default.
- W4313335044 cites W2056958245 @default.
- W4313335044 cites W2066347230 @default.
- W4313335044 cites W2067907875 @default.
- W4313335044 cites W2069132198 @default.
- W4313335044 cites W2075781827 @default.
- W4313335044 cites W2081524299 @default.
- W4313335044 cites W2081704409 @default.
- W4313335044 cites W2083508061 @default.
- W4313335044 cites W2083801136 @default.
- W4313335044 cites W2085976990 @default.
- W4313335044 cites W2087561465 @default.
- W4313335044 cites W2089172549 @default.
- W4313335044 cites W2090743418 @default.
- W4313335044 cites W2118477707 @default.
- W4313335044 cites W2122400789 @default.
- W4313335044 cites W2146448037 @default.
- W4313335044 cites W2152353759 @default.
- W4313335044 cites W2164180561 @default.
- W4313335044 cites W2292619439 @default.
- W4313335044 cites W4246089228 @default.
- W4313335044 doi "https://doi.org/10.4049/jimmunol.163.2.668" @default.
- W4313335044 hasPublicationYear "1999" @default.
- W4313335044 type Work @default.
- W4313335044 citedByCount "35" @default.
- W4313335044 countsByYear W43133350442014 @default.
- W4313335044 countsByYear W43133350442015 @default.
- W4313335044 countsByYear W43133350442016 @default.
- W4313335044 countsByYear W43133350442017 @default.
- W4313335044 countsByYear W43133350442018 @default.
- W4313335044 countsByYear W43133350442020 @default.
- W4313335044 countsByYear W43133350442021 @default.
- W4313335044 countsByYear W43133350442022 @default.
- W4313335044 countsByYear W43133350442023 @default.
- W4313335044 crossrefType "journal-article" @default.
- W4313335044 hasAuthorship W4313335044A5010409179 @default.
- W4313335044 hasAuthorship W4313335044A5025747144 @default.
- W4313335044 hasAuthorship W4313335044A5036072797 @default.
- W4313335044 hasAuthorship W4313335044A5081410860 @default.
- W4313335044 hasBestOaLocation W43133350441 @default.
- W4313335044 hasConcept C104317684 @default.
- W4313335044 hasConcept C11960822 @default.
- W4313335044 hasConcept C124160383 @default.
- W4313335044 hasConcept C1629964 @default.
- W4313335044 hasConcept C170493617 @default.
- W4313335044 hasConcept C184235292 @default.
- W4313335044 hasConcept C185946421 @default.
- W4313335044 hasConcept C199172495 @default.
- W4313335044 hasConcept C2909511254 @default.
- W4313335044 hasConcept C49039625 @default.
- W4313335044 hasConcept C55493867 @default.
- W4313335044 hasConcept C62478195 @default.
- W4313335044 hasConcept C79879829 @default.
- W4313335044 hasConcept C86339819 @default.
- W4313335044 hasConcept C86803240 @default.
- W4313335044 hasConcept C88045685 @default.
- W4313335044 hasConcept C90934575 @default.
- W4313335044 hasConcept C95444343 @default.
- W4313335044 hasConcept C97029542 @default.
- W4313335044 hasConceptScore W4313335044C104317684 @default.
- W4313335044 hasConceptScore W4313335044C11960822 @default.
- W4313335044 hasConceptScore W4313335044C124160383 @default.