Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335066> ?p ?o ?g. }
- W4313335066 endingPage "1080" @default.
- W4313335066 startingPage "1073" @default.
- W4313335066 abstract "Abstract Recent studies revealing active mechanisms of immune privilege in neural tissues have diminished the putative role of passive tolerance. To examine the significance of Ag localization in the retina on immune privilege, the immune responses of transgenic mice expressing high and low levels of β-galactosidase (β-gal) in the photoreceptor cells of the retina were compared with those of normal mice and those of mice expressing moderate levels of β-gal systemically. Immunization with β-gal induced experimental autoimmune uveoretinitis indistinguishable from that induced by known photoreceptor cell autoantigens, including destruction of photoreceptor cells, in transgenic mice with high level retinal expression. Retinal expression had no apparent effect on the immune responses to β-gal, showing that tolerance was not elicited by levels of retinal β-gal sufficient to serve as a target for autoimmune disease. Mice with systemic expression exhibited reduced lymphoproliferative responses following immunization with β-gal and did not develop autoimmune disease. T cells prepared from normal mice immunized with β-gal transferred experimental autoimmune uveoretinitis to the transgenic mice with high level retinal β-gal expression, but no disease was found in mice with systemic transgene expression under these conditions. The results of our experiments are most consistent with sequestration being the primary mechanism of retinal immune privilege. The results also show that β-gal can serve as an immunopathogenic neural autoantigen, and that T cells raised by immunization of normal mice with a foreign Ag can be immunopathogenic in certain transgenic recipients." @default.
- W4313335066 created "2023-01-06" @default.
- W4313335066 creator A5012456017 @default.
- W4313335066 creator A5018658424 @default.
- W4313335066 creator A5021530758 @default.
- W4313335066 creator A5035222785 @default.
- W4313335066 creator A5040841311 @default.
- W4313335066 creator A5041448642 @default.
- W4313335066 date "1999-07-15" @default.
- W4313335066 modified "2023-10-17" @default.
- W4313335066 title "Retinal Expression of a Neo-Self Antigen, β-Galactosidase, Is Not Tolerogenic and Creates a Target for Autoimmune Uveoretinitis" @default.
- W4313335066 cites W1493257440 @default.
- W4313335066 cites W1497312799 @default.
- W4313335066 cites W1536701352 @default.
- W4313335066 cites W1546716086 @default.
- W4313335066 cites W1564408629 @default.
- W4313335066 cites W1567912931 @default.
- W4313335066 cites W1633194666 @default.
- W4313335066 cites W1639540363 @default.
- W4313335066 cites W1971926377 @default.
- W4313335066 cites W1974810488 @default.
- W4313335066 cites W1976556558 @default.
- W4313335066 cites W1978018492 @default.
- W4313335066 cites W1983821876 @default.
- W4313335066 cites W1983880463 @default.
- W4313335066 cites W1989760484 @default.
- W4313335066 cites W1993016015 @default.
- W4313335066 cites W1998260263 @default.
- W4313335066 cites W1998508652 @default.
- W4313335066 cites W2005320381 @default.
- W4313335066 cites W2012795872 @default.
- W4313335066 cites W2039117471 @default.
- W4313335066 cites W2046026976 @default.
- W4313335066 cites W2052537256 @default.
- W4313335066 cites W2055485094 @default.
- W4313335066 cites W2056457931 @default.
- W4313335066 cites W2059315606 @default.
- W4313335066 cites W2059864624 @default.
- W4313335066 cites W2077402228 @default.
- W4313335066 cites W2085065264 @default.
- W4313335066 cites W2085207145 @default.
- W4313335066 cites W2110808794 @default.
- W4313335066 cites W2120887760 @default.
- W4313335066 cites W2137560059 @default.
- W4313335066 cites W2141506670 @default.
- W4313335066 cites W2145524613 @default.
- W4313335066 cites W2149510483 @default.
- W4313335066 cites W2154491580 @default.
- W4313335066 cites W2154609389 @default.
- W4313335066 cites W2156278296 @default.
- W4313335066 cites W2163357710 @default.
- W4313335066 cites W4230583809 @default.
- W4313335066 cites W4240008883 @default.
- W4313335066 cites W4313324526 @default.
- W4313335066 doi "https://doi.org/10.4049/jimmunol.163.2.1073" @default.
- W4313335066 hasPublicationYear "1999" @default.
- W4313335066 type Work @default.
- W4313335066 citedByCount "24" @default.
- W4313335066 countsByYear W43133350662012 @default.
- W4313335066 countsByYear W43133350662013 @default.
- W4313335066 countsByYear W43133350662014 @default.
- W4313335066 countsByYear W43133350662015 @default.
- W4313335066 countsByYear W43133350662016 @default.
- W4313335066 countsByYear W43133350662021 @default.
- W4313335066 countsByYear W43133350662022 @default.
- W4313335066 crossrefType "journal-article" @default.
- W4313335066 hasAuthorship W4313335066A5012456017 @default.
- W4313335066 hasAuthorship W4313335066A5018658424 @default.
- W4313335066 hasAuthorship W4313335066A5021530758 @default.
- W4313335066 hasAuthorship W4313335066A5035222785 @default.
- W4313335066 hasAuthorship W4313335066A5040841311 @default.
- W4313335066 hasAuthorship W4313335066A5041448642 @default.
- W4313335066 hasBestOaLocation W43133350661 @default.
- W4313335066 hasConcept C102230213 @default.
- W4313335066 hasConcept C104317684 @default.
- W4313335066 hasConcept C141035611 @default.
- W4313335066 hasConcept C147483822 @default.
- W4313335066 hasConcept C159654299 @default.
- W4313335066 hasConcept C169760540 @default.
- W4313335066 hasConcept C203014093 @default.
- W4313335066 hasConcept C2777093970 @default.
- W4313335066 hasConcept C2777702733 @default.
- W4313335066 hasConcept C2779075594 @default.
- W4313335066 hasConcept C2780130043 @default.
- W4313335066 hasConcept C2780801004 @default.
- W4313335066 hasConcept C2780827179 @default.
- W4313335066 hasConcept C2781185574 @default.
- W4313335066 hasConcept C54355233 @default.
- W4313335066 hasConcept C55493867 @default.
- W4313335066 hasConcept C86803240 @default.
- W4313335066 hasConcept C8891405 @default.
- W4313335066 hasConceptScore W4313335066C102230213 @default.
- W4313335066 hasConceptScore W4313335066C104317684 @default.
- W4313335066 hasConceptScore W4313335066C141035611 @default.
- W4313335066 hasConceptScore W4313335066C147483822 @default.
- W4313335066 hasConceptScore W4313335066C159654299 @default.
- W4313335066 hasConceptScore W4313335066C169760540 @default.
- W4313335066 hasConceptScore W4313335066C203014093 @default.