Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335080> ?p ?o ?g. }
- W4313335080 endingPage "598" @default.
- W4313335080 startingPage "590" @default.
- W4313335080 abstract "Abstract NF-κB is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells. Our findings show that suppression of NF-κB activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-κB1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL. Inhibition of NF-κB resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis. DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent. Interestingly, apoptosis induced by NF-κB suppression, in contrast to that induced by TPEN (N,N,N′,N′-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45. These findings suggest either low level of activation is required or that different caspases are involved. Preactivation of T cells resulting in NF-κB nuclear translocation protected cells from SN50-induced apoptosis. Our findings demonstrate an essential role of NF-κB in survival of naive PBL." @default.
- W4313335080 created "2023-01-06" @default.
- W4313335080 creator A5005282856 @default.
- W4313335080 creator A5027080346 @default.
- W4313335080 creator A5045634878 @default.
- W4313335080 creator A5053938589 @default.
- W4313335080 creator A5066748171 @default.
- W4313335080 creator A5082466279 @default.
- W4313335080 date "1999-07-15" @default.
- W4313335080 modified "2023-10-16" @default.
- W4313335080 title "Inhibition of NF-κB Activity in Human T Lymphocytes Induces Caspase-Dependent Apoptosis Without Detectable Activation of Caspase-1 and -3" @default.
- W4313335080 cites W125106425 @default.
- W4313335080 cites W1480050981 @default.
- W4313335080 cites W1486344723 @default.
- W4313335080 cites W1486963590 @default.
- W4313335080 cites W1497061219 @default.
- W4313335080 cites W1517251498 @default.
- W4313335080 cites W1545494913 @default.
- W4313335080 cites W1573050868 @default.
- W4313335080 cites W1581191814 @default.
- W4313335080 cites W1585247532 @default.
- W4313335080 cites W1598082435 @default.
- W4313335080 cites W1611047887 @default.
- W4313335080 cites W1859862271 @default.
- W4313335080 cites W1915074145 @default.
- W4313335080 cites W1916576520 @default.
- W4313335080 cites W1940692702 @default.
- W4313335080 cites W1964094843 @default.
- W4313335080 cites W1965583590 @default.
- W4313335080 cites W1979842763 @default.
- W4313335080 cites W1981106016 @default.
- W4313335080 cites W1982062664 @default.
- W4313335080 cites W1990917512 @default.
- W4313335080 cites W1996180957 @default.
- W4313335080 cites W2002503549 @default.
- W4313335080 cites W2004487378 @default.
- W4313335080 cites W2015313594 @default.
- W4313335080 cites W2018011543 @default.
- W4313335080 cites W2025108978 @default.
- W4313335080 cites W2040470926 @default.
- W4313335080 cites W2051918665 @default.
- W4313335080 cites W2054260525 @default.
- W4313335080 cites W2056019276 @default.
- W4313335080 cites W2068122289 @default.
- W4313335080 cites W2070853191 @default.
- W4313335080 cites W2074678011 @default.
- W4313335080 cites W2081145901 @default.
- W4313335080 cites W2082259697 @default.
- W4313335080 cites W2082575834 @default.
- W4313335080 cites W2084261874 @default.
- W4313335080 cites W2085236534 @default.
- W4313335080 cites W2085351407 @default.
- W4313335080 cites W2091734110 @default.
- W4313335080 cites W2091783976 @default.
- W4313335080 cites W2092759765 @default.
- W4313335080 cites W2095019663 @default.
- W4313335080 cites W2098160574 @default.
- W4313335080 cites W2098712005 @default.
- W4313335080 cites W2101759139 @default.
- W4313335080 cites W2105896882 @default.
- W4313335080 cites W2122538814 @default.
- W4313335080 cites W2145028144 @default.
- W4313335080 cites W2145664512 @default.
- W4313335080 cites W2151892297 @default.
- W4313335080 cites W2166291746 @default.
- W4313335080 cites W2168889062 @default.
- W4313335080 cites W2209259861 @default.
- W4313335080 cites W2280929046 @default.
- W4313335080 cites W2288500425 @default.
- W4313335080 cites W2299163506 @default.
- W4313335080 cites W4232200428 @default.
- W4313335080 cites W4313343508 @default.
- W4313335080 cites W95988660 @default.
- W4313335080 doi "https://doi.org/10.4049/jimmunol.163.2.590" @default.
- W4313335080 hasPublicationYear "1999" @default.
- W4313335080 type Work @default.
- W4313335080 citedByCount "60" @default.
- W4313335080 countsByYear W43133350802012 @default.
- W4313335080 countsByYear W43133350802017 @default.
- W4313335080 countsByYear W43133350802019 @default.
- W4313335080 countsByYear W43133350802021 @default.
- W4313335080 countsByYear W43133350802022 @default.
- W4313335080 countsByYear W43133350802023 @default.
- W4313335080 crossrefType "journal-article" @default.
- W4313335080 hasAuthorship W4313335080A5005282856 @default.
- W4313335080 hasAuthorship W4313335080A5027080346 @default.
- W4313335080 hasAuthorship W4313335080A5045634878 @default.
- W4313335080 hasAuthorship W4313335080A5053938589 @default.
- W4313335080 hasAuthorship W4313335080A5066748171 @default.
- W4313335080 hasAuthorship W4313335080A5082466279 @default.
- W4313335080 hasBestOaLocation W43133350801 @default.
- W4313335080 hasConcept C12519072 @default.
- W4313335080 hasConcept C153911025 @default.
- W4313335080 hasConcept C181199279 @default.
- W4313335080 hasConcept C182220744 @default.
- W4313335080 hasConcept C182979987 @default.
- W4313335080 hasConcept C190283241 @default.
- W4313335080 hasConcept C2775998712 @default.