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- W4313335094 endingPage "3137" @default.
- W4313335094 startingPage "3131" @default.
- W4313335094 abstract "Abstract IL-2-dependent, activation-induced T cell death (AICD) plays an important role in peripheral tolerance. Using CD8+ TCR-transgenic lymphocytes (2C), we investigated the mechanisms by which IL-2 prepares CD8+ T cells for AICD. We found that both Fas and TNFR death pathways mediate the AICD of 2C cells. Neutralizing IL-2, IL-2Rα, or IL-2Rβ inhibited AICD. In contrast, blocking the common cytokine receptor γ-chain (γc) prevented Bcl-2 induction and augmented AICD. IL-2 up-regulated Fas ligand (FasL) and down-regulated γc expression on activated 2C cells in vitro and in vivo. Adult IL-2 gene-knockout mice displayed exaggerated γc expression on their CD8+, but not on their CD4+, T cells. IL-4, IL-7, and IL-15, which do not promote AICD, did not influence FasL or γc expression. These data provide evidence that IL-2 prepares CD8+ T lymphocytes for AICD by at least two mechanisms: 1) by up-regulating a pro-apoptotic molecule, FasL, and 2) by down-regulating a survival molecule, γc." @default.
- W4313335094 created "2023-01-06" @default.
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- W4313335094 date "1999-09-15" @default.
- W4313335094 modified "2023-10-09" @default.
- W4313335094 title "The Role of the Common Cytokine Receptor γ-Chain in Regulating IL-2-Dependent, Activation-Induced CD8+ T Cell Death" @default.
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- W4313335094 doi "https://doi.org/10.4049/jimmunol.163.6.3131" @default.
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