FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335099> ?p ?o ?g. }

• W4313335099 endingPage "5465" @default.
• W4313335099 startingPage "5455" @default.
• W4313335099 abstract "Abstract We investigated the effects of IgE versus IL-4 on FcεRI surface expression in differentiated human mast cells derived in vitro from umbilical cord blood mononuclear cells. We found that IgE (at 5 μg/ml) much more strikingly enhanced surface expression of FcεRI than did IL-4 (at 0.1–100 ng/ml); similar results were also obtained with differentiated mouse mast cells. However, IL-4 acted synergistically with IgE to enhance FcεRI expression in these umbilical cord blood-derived human mast cells, as well as in mouse peritoneal mast cells derived from IL-4−/− or IL-4+/+ mice. We also found that: 1) IgE-dependent enhancement of FcεRI expression was associated with a significantly enhanced ability of these human mast cells to secrete histamine, PGD2, and leukotriene C4 upon subsequent passive sensitization with IgE and challenge with anti-IgE; 2) preincubation with IL-4 enhanced IgE-dependent mediator secretion in these cells even in the absence of significant effects on FcεRI surface expression; 3) when used together with IgE, IL-4 enhanced IgE-dependent mediator secretion in human mast cells to levels greater than those observed in cells that had been preincubated with IgE alone; and 4) batches of human mast cells generated in vitro from umbilical cord blood cells derived from different donors exhibited differences in the magnitude and pattern of histamine and lipid mediator release in response to anti-IgE challenge, both under baseline conditions and after preincubation with IgE and/or IL-4." @default.
• W4313335099 created "2023-01-06" @default.
• W4313335099 creator A5001389064 @default.
• W4313335099 creator A5004151297 @default.
• W4313335099 creator A5023258814 @default.
• W4313335099 creator A5026452247 @default.
• W4313335099 creator A5034657539 @default.
• W4313335099 creator A5041577012 @default.
• W4313335099 creator A5041655848 @default.
• W4313335099 creator A5044327796 @default.
• W4313335099 date "1999-05-01" @default.
• W4313335099 modified "2023-10-15" @default.
• W4313335099 title "IgE Enhances Fcε Receptor I Expression and IgE-Dependent Release of Histamine and Lipid Mediators from Human Umbilical Cord Blood-Derived Mast Cells: Synergistic Effect of IL-4 and IgE on Human Mast Cell Fcε Receptor I Expression and Mediator Release" @default.
• W4313335099 cites W1464079956 @default.
• W4313335099 cites W1519920057 @default.
• W4313335099 cites W1528328673 @default.
• W4313335099 cites W1560052830 @default.
• W4313335099 cites W1644325419 @default.
• W4313335099 cites W1655614253 @default.
• W4313335099 cites W1870393463 @default.
• W4313335099 cites W1910182345 @default.
• W4313335099 cites W1926875153 @default.
• W4313335099 cites W1963169432 @default.
• W4313335099 cites W1972108403 @default.
• W4313335099 cites W1990367169 @default.
• W4313335099 cites W1997531619 @default.
• W4313335099 cites W2021475285 @default.
• W4313335099 cites W2024931925 @default.
• W4313335099 cites W2044309378 @default.
• W4313335099 cites W2047278261 @default.
• W4313335099 cites W2052411461 @default.
• W4313335099 cites W2057887597 @default.
• W4313335099 cites W2069026692 @default.
• W4313335099 cites W2073989221 @default.
• W4313335099 cites W2081973949 @default.
• W4313335099 cites W2083502937 @default.
• W4313335099 cites W2087512006 @default.
• W4313335099 cites W2088310945 @default.
• W4313335099 cites W2125020800 @default.
• W4313335099 cites W2127842048 @default.
• W4313335099 cites W2135510232 @default.
• W4313335099 cites W2154196772 @default.
• W4313335099 cites W2170248440 @default.
• W4313335099 cites W2339022261 @default.
• W4313335099 cites W4236001543 @default.
• W4313335099 cites W4249736906 @default.
• W4313335099 cites W4252913591 @default.
• W4313335099 cites W4313306007 @default.
• W4313335099 cites W4313306026 @default.
• W4313335099 cites W4313315104 @default.
• W4313335099 doi "https://doi.org/10.4049/jimmunol.162.9.5455" @default.
• W4313335099 hasPublicationYear "1999" @default.
• W4313335099 type Work @default.
• W4313335099 citedByCount "139" @default.
• W4313335099 countsByYear W43133350992012 @default.
• W4313335099 countsByYear W43133350992013 @default.
• W4313335099 countsByYear W43133350992014 @default.
• W4313335099 countsByYear W43133350992015 @default.
• W4313335099 countsByYear W43133350992016 @default.
• W4313335099 countsByYear W43133350992017 @default.
• W4313335099 countsByYear W43133350992018 @default.
• W4313335099 countsByYear W43133350992019 @default.
• W4313335099 countsByYear W43133350992020 @default.
• W4313335099 countsByYear W43133350992021 @default.
• W4313335099 countsByYear W43133350992022 @default.
• W4313335099 countsByYear W43133350992023 @default.
• W4313335099 crossrefType "journal-article" @default.
• W4313335099 hasAuthorship W4313335099A5001389064 @default.
• W4313335099 hasAuthorship W4313335099A5004151297 @default.
• W4313335099 hasAuthorship W4313335099A5023258814 @default.
• W4313335099 hasAuthorship W4313335099A5026452247 @default.
• W4313335099 hasAuthorship W4313335099A5034657539 @default.
• W4313335099 hasAuthorship W4313335099A5041577012 @default.
• W4313335099 hasAuthorship W4313335099A5041655848 @default.
• W4313335099 hasAuthorship W4313335099A5044327796 @default.
• W4313335099 hasBestOaLocation W43133350991 @default.
• W4313335099 hasConcept C1122143 @default.
• W4313335099 hasConcept C134018914 @default.
• W4313335099 hasConcept C137061746 @default.
• W4313335099 hasConcept C141105273 @default.
• W4313335099 hasConcept C159654299 @default.
• W4313335099 hasConcept C185592680 @default.
• W4313335099 hasConcept C202751555 @default.
• W4313335099 hasConcept C203014093 @default.
• W4313335099 hasConcept C2776955114 @default.
• W4313335099 hasConcept C2779726688 @default.
• W4313335099 hasConcept C2780914630 @default.
• W4313335099 hasConcept C49039625 @default.
• W4313335099 hasConcept C55493867 @default.
• W4313335099 hasConcept C86803240 @default.
• W4313335099 hasConceptScore W4313335099C1122143 @default.
• W4313335099 hasConceptScore W4313335099C134018914 @default.
• W4313335099 hasConceptScore W4313335099C137061746 @default.
• W4313335099 hasConceptScore W4313335099C141105273 @default.
• W4313335099 hasConceptScore W4313335099C159654299 @default.
• W4313335099 hasConceptScore W4313335099C185592680 @default.
• W4313335099 hasConceptScore W4313335099C202751555 @default.
• W4313335099 hasConceptScore W4313335099C203014093 @default.

• next