FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335110> ?p ?o ?g. }

• W4313335110 endingPage "3184" @default.
• W4313335110 startingPage "3176" @default.
• W4313335110 abstract "Abstract Fetal mouse NK cells are grossly deficient in the expression of Ly49 molecules yet show a limited ability to distinguish between wild-type and MHC class I-deficient target cells. In this paper we report that during their development in vitro from immature thymic progenitors, a proportion of C57BL/6 fetal NK cells acquires receptors for a soluble form of the nonclassical class I molecule Qa1b associated with the Qdm peptide, but not for soluble forms of the classical class I molecules Kb and Db. The acquisition of these Qa1 receptors occurs in a stochastic manner that is strictly controlled by cytokines, and in particular is strongly inhibited by IL-4. All fetal NK clones tested, including those that lack detectable Qa1 receptors, express mRNA for CD94 and for both inhibitory and noninhibitory members of the NKG2 family. Fetal NK cells lacking receptors for Qa1 (and also for classical class I molecules) cannot distinguish between wild-type and class I-deficient blasts but, surprisingly, distinguish efficiently between certain wild-type and class I-deficient tumor cells. A variant line that lacks several members of the NKG2 family kills both types of tumor cell equally well, suggesting the existence of NKG2-containing inhibitory receptors that recognize as yet undefined nonclassical class I molecules of restricted distribution." @default.
• W4313335110 created "2023-01-06" @default.
• W4313335110 creator A5031298418 @default.
• W4313335110 creator A5034489483 @default.
• W4313335110 creator A5035590418 @default.
• W4313335110 creator A5045752749 @default.
• W4313335110 creator A5049035998 @default.
• W4313335110 creator A5049990975 @default.
• W4313335110 creator A5051794075 @default.
• W4313335110 creator A5067543504 @default.
• W4313335110 creator A5073148390 @default.
• W4313335110 creator A5078706669 @default.
• W4313335110 creator A5082938388 @default.
• W4313335110 creator A5084372550 @default.
• W4313335110 date "1999-09-15" @default.
• W4313335110 modified "2023-10-10" @default.
• W4313335110 title "Stochastic Acquisition of Qa1 Receptors During the Development of Fetal NK Cells In Vitro Accounts in Part But Not in Whole for the Ability of These Cells to Distinguish Between Class I-Sufficient and Class I-Deficient Targets" @default.
• W4313335110 cites W1499140105 @default.
• W4313335110 cites W1528765764 @default.
• W4313335110 cites W1549551064 @default.
• W4313335110 cites W1558024223 @default.
• W4313335110 cites W1580159410 @default.
• W4313335110 cites W1588296938 @default.
• W4313335110 cites W1902747615 @default.
• W4313335110 cites W1975922811 @default.
• W4313335110 cites W1976756827 @default.
• W4313335110 cites W1977597577 @default.
• W4313335110 cites W1992185378 @default.
• W4313335110 cites W1994255893 @default.
• W4313335110 cites W1997257161 @default.
• W4313335110 cites W2001407458 @default.
• W4313335110 cites W2005765588 @default.
• W4313335110 cites W2007184342 @default.
• W4313335110 cites W2008141882 @default.
• W4313335110 cites W2014208459 @default.
• W4313335110 cites W2020287922 @default.
• W4313335110 cites W2022609860 @default.
• W4313335110 cites W2029521673 @default.
• W4313335110 cites W2038301799 @default.
• W4313335110 cites W2042110812 @default.
• W4313335110 cites W2044410917 @default.
• W4313335110 cites W2060081000 @default.
• W4313335110 cites W2060404865 @default.
• W4313335110 cites W2066271363 @default.
• W4313335110 cites W2075396011 @default.
• W4313335110 cites W2080993722 @default.
• W4313335110 cites W2088513299 @default.
• W4313335110 cites W2092354449 @default.
• W4313335110 cites W2095569760 @default.
• W4313335110 cites W2116171543 @default.
• W4313335110 cites W2130035360 @default.
• W4313335110 cites W2131625721 @default.
• W4313335110 cites W2144891041 @default.
• W4313335110 cites W2147152214 @default.
• W4313335110 cites W2154892697 @default.
• W4313335110 cites W2158461140 @default.
• W4313335110 cites W2160520392 @default.
• W4313335110 cites W2165660210 @default.
• W4313335110 cites W2186755194 @default.
• W4313335110 cites W4313333782 @default.
• W4313335110 cites W99199752 @default.
• W4313335110 doi "https://doi.org/10.4049/jimmunol.163.6.3176" @default.
• W4313335110 hasPublicationYear "1999" @default.
• W4313335110 type Work @default.
• W4313335110 citedByCount "19" @default.
• W4313335110 crossrefType "journal-article" @default.
• W4313335110 hasAuthorship W4313335110A5031298418 @default.
• W4313335110 hasAuthorship W4313335110A5034489483 @default.
• W4313335110 hasAuthorship W4313335110A5035590418 @default.
• W4313335110 hasAuthorship W4313335110A5045752749 @default.
• W4313335110 hasAuthorship W4313335110A5049035998 @default.
• W4313335110 hasAuthorship W4313335110A5049990975 @default.
• W4313335110 hasAuthorship W4313335110A5051794075 @default.
• W4313335110 hasAuthorship W4313335110A5067543504 @default.
• W4313335110 hasAuthorship W4313335110A5073148390 @default.
• W4313335110 hasAuthorship W4313335110A5078706669 @default.
• W4313335110 hasAuthorship W4313335110A5082938388 @default.
• W4313335110 hasAuthorship W4313335110A5084372550 @default.
• W4313335110 hasBestOaLocation W43133351101 @default.
• W4313335110 hasConcept C153911025 @default.
• W4313335110 hasConcept C154317977 @default.
• W4313335110 hasConcept C170493617 @default.
• W4313335110 hasConcept C170627219 @default.
• W4313335110 hasConcept C202751555 @default.
• W4313335110 hasConcept C203014093 @default.
• W4313335110 hasConcept C54355233 @default.
• W4313335110 hasConcept C86803240 @default.
• W4313335110 hasConcept C95444343 @default.
• W4313335110 hasConceptScore W4313335110C153911025 @default.
• W4313335110 hasConceptScore W4313335110C154317977 @default.
• W4313335110 hasConceptScore W4313335110C170493617 @default.
• W4313335110 hasConceptScore W4313335110C170627219 @default.
• W4313335110 hasConceptScore W4313335110C202751555 @default.
• W4313335110 hasConceptScore W4313335110C203014093 @default.
• W4313335110 hasConceptScore W4313335110C54355233 @default.
• W4313335110 hasConceptScore W4313335110C86803240 @default.
• W4313335110 hasConceptScore W4313335110C95444343 @default.
• W4313335110 hasIssue "6" @default.

• next