FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313335220> ?p ?o ?g. }

• W4313335220 abstract "Background The chronically instrumented non-anesthetized fetal sheep (CINAFS) model has been a mainstay of human fetal development research for the past 60 years. As a large two for one animal model, involving the instrumentation of the ewe and her fetus, the model poses challenges to implement de novo and maintain overtime at the highest standards of operating procedures to ensure ongoing performance. A common yet conventionally underreported issue researchers face is a high rate of animal loss. Here, we investigate what determines the success of the CINAFS model of human development. Methods We conducted a retrospective cohort analysis consisting of 82 experiments spanning the course of six years. Our team identified 10 variables that we anticipated were likely to influence the experimental outcome, such as the time of year, animal size, and surgical complexity. To evaluate the role of each variable in contributing to the success of the model, a binary logit regression analysis with a Fisher scoring optimization was fit to the data (SAS, V9 engine, release 3.8, SAS Institute, Cary, NC, USA). A higher predictive probability indicates a larger impact by the given variable on the outcome of the experiment. A Wald chi-squared analysis was run on the data to control for confounders and determine significance. Results The single variable identified in this study as determining the success of experiment outcomes using the CINAFS model is the experience level of the team. Conclusion The CINAFS model offers enormous potential to further our understanding of human fetal development and create interventional technologies related to fetal health. However, to improve experimental outcomes using the CINAFS model, stronger communication and training are needed. We discuss the implications of our findings for the successful implementation of this challenging yet scientifically advantageous animal model of human physiology." @default.
• W4313335220 created "2023-01-06" @default.
• W4313335220 creator A5003830470 @default.
• W4313335220 creator A5004603346 @default.
• W4313335220 creator A5022504358 @default.
• W4313335220 creator A5034432949 @default.
• W4313335220 creator A5056157817 @default.
• W4313335220 creator A5060305035 @default.
• W4313335220 date "2022-12-17" @default.
• W4313335220 modified "2023-10-17" @default.
• W4313335220 title "Factors Determining the Success of the Chronically Instrumented Non-anesthetized Fetal Sheep Model of Human Development: A Retrospective Cohort Study" @default.
• W4313335220 cites W1847611437 @default.
• W4313335220 cites W1961621860 @default.
• W4313335220 cites W1996341174 @default.
• W4313335220 cites W2027914644 @default.
• W4313335220 cites W2069368135 @default.
• W4313335220 cites W2094725377 @default.
• W4313335220 cites W2164994753 @default.
• W4313335220 cites W2555332312 @default.
• W4313335220 cites W2609105226 @default.
• W4313335220 cites W2621553775 @default.
• W4313335220 cites W2801499275 @default.
• W4313335220 cites W2896962462 @default.
• W4313335220 cites W2921118220 @default.
• W4313335220 cites W2995987390 @default.
• W4313335220 cites W3025602991 @default.
• W4313335220 cites W3074404232 @default.
• W4313335220 cites W4221165520 @default.
• W4313335220 doi "https://doi.org/10.7759/cureus.32632" @default.
• W4313335220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36660509" @default.
• W4313335220 hasPublicationYear "2022" @default.
• W4313335220 type Work @default.
• W4313335220 citedByCount "0" @default.
• W4313335220 crossrefType "journal-article" @default.
• W4313335220 hasAuthorship W4313335220A5003830470 @default.
• W4313335220 hasAuthorship W4313335220A5004603346 @default.
• W4313335220 hasAuthorship W4313335220A5022504358 @default.
• W4313335220 hasAuthorship W4313335220A5034432949 @default.
• W4313335220 hasAuthorship W4313335220A5056157817 @default.
• W4313335220 hasAuthorship W4313335220A5060305035 @default.
• W4313335220 hasBestOaLocation W43133352201 @default.
• W4313335220 hasConcept C105795698 @default.
• W4313335220 hasConcept C126322002 @default.
• W4313335220 hasConcept C141071460 @default.
• W4313335220 hasConcept C151956035 @default.
• W4313335220 hasConcept C152877465 @default.
• W4313335220 hasConcept C167135981 @default.
• W4313335220 hasConcept C33923547 @default.
• W4313335220 hasConcept C71924100 @default.
• W4313335220 hasConcept C72563966 @default.
• W4313335220 hasConcept C77350462 @default.
• W4313335220 hasConceptScore W4313335220C105795698 @default.
• W4313335220 hasConceptScore W4313335220C126322002 @default.
• W4313335220 hasConceptScore W4313335220C141071460 @default.
• W4313335220 hasConceptScore W4313335220C151956035 @default.
• W4313335220 hasConceptScore W4313335220C152877465 @default.
• W4313335220 hasConceptScore W4313335220C167135981 @default.
• W4313335220 hasConceptScore W4313335220C33923547 @default.
• W4313335220 hasConceptScore W4313335220C71924100 @default.
• W4313335220 hasConceptScore W4313335220C72563966 @default.
• W4313335220 hasConceptScore W4313335220C77350462 @default.
• W4313335220 hasLocation W43133352201 @default.
• W4313335220 hasLocation W43133352202 @default.
• W4313335220 hasLocation W43133352203 @default.
• W4313335220 hasOpenAccess W4313335220 @default.
• W4313335220 hasPrimaryLocation W43133352201 @default.
• W4313335220 hasRelatedWork W1545592973 @default.
• W4313335220 hasRelatedWork W2063767105 @default.
• W4313335220 hasRelatedWork W2068889012 @default.
• W4313335220 hasRelatedWork W2127072394 @default.
• W4313335220 hasRelatedWork W2130373985 @default.
• W4313335220 hasRelatedWork W2417169073 @default.
• W4313335220 hasRelatedWork W3039480810 @default.
• W4313335220 hasRelatedWork W4296177128 @default.
• W4313335220 hasRelatedWork W4320489638 @default.
• W4313335220 hasRelatedWork W4384558369 @default.
• W4313335220 isParatext "false" @default.
• W4313335220 isRetracted "false" @default.
• W4313335220 workType "article" @default.