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- W4313335791 endingPage "2377" @default.
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- W4313335791 abstract "Abstract NK T cells recognize glycolipid Ags such as α-galactosylceramide (α-GalCer) presented by the MHC class I-like molecule CD1d. In this paper we have studied the in vivo effects of α-GalCer on the generation of adaptive immune responses. Treatment of mice with α-GalCer resulted in rapid activation of NK T cells and production of the cytokines IL-4 and IFN-γ. However, after this initial stimulation, NK T cells became polarized for the production of IL-4. Further, as soon as 6 days after α-GalCer injection, a marked increase in serum IgE levels was observed. Administration of α-GalCer at the time of priming of mice with protein Ag resulted in the generation of Ag-specific Th2 cells and a profound increase in the production of IgE. Collectively, these findings indicate that α-GalCer may be useful for modulating immune responses toward a Th2 phenotype during prophylaxis and therapy." @default.
- W4313335791 created "2023-01-06" @default.
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- W4313335791 date "1999-09-01" @default.
- W4313335791 modified "2023-10-16" @default.
- W4313335791 title "Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype" @default.
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- W4313335791 doi "https://doi.org/10.4049/jimmunol.163.5.2373" @default.
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