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- W4313336431 endingPage "70" @default.
- W4313336431 startingPage "32" @default.
- W4313336431 abstract "With the rising levels of drug resistance, developing efficient antimicrobial therapies has become a priority. A promising strategy is the conjugation of antibiotics with relevant moieties that can potentiate their activity by target-directing. The conjugation of siderophores with antibiotics allows them to act as Trojan horses by hijacking the microorganisms' highly developed iron transport systems and using them to carry the antibiotic into the cell. Through the analysis of relevant examples of the past decade, this Perspective aims to reveal the potential of siderophore-antibiotic Trojan horses for the treatment of infections and the role of siderophores in diagnostic techniques. Other conjugated molecules will be the subject of discussion, namely those involving vitamin B12, carbohydrates, and amino acids, as well as conjugated compounds targeting protein degradation and β-lactamase activated prodrugs." @default.
- W4313336431 created "2023-01-06" @default.
- W4313336431 creator A5001953384 @default.
- W4313336431 creator A5027756968 @default.
- W4313336431 creator A5030541635 @default.
- W4313336431 creator A5059404671 @default.
- W4313336431 date "2022-12-31" @default.
- W4313336431 modified "2023-10-14" @default.
- W4313336431 title "Emerging Target-Directed Approaches for the Treatment and Diagnosis of Microbial Infections" @default.
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