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- W4313339190 abstract "Abstract We have previously reported that chicken 7S immunoglobulin (Ig) heavy (H) chain allotypes (CS-1 locus) segregate as phenogroups in F2 progeny. Specificity CS-1.1 formed a phenogroup with CS-1.4 in inbred chicken line UCD 2, and a second phenogroup with CS-1.3 in line UCD 3. To determine whether these phenogroups were formed by combinations of specificities on the same, or on separate subclasses of 7S Ig, their distribution on the 7S Ig molecules of birds homozygous for 7S Ig allotypes was analyzed by radioimmunoassay. Anti-CS-1.1 and anti-CS-1.3 alloantisera each bound more than 94% of line UCD 3 125I-7S Ig. Similar results were obtained with alloantisera to CS-1.1 and CS-1.4 with 125I-7S Ig from line UCD 2. These results indicate that both phenogroups were formed by combinations of specificities present on the same H chain. Thus, each phenogroup described, probably, is the product of a single structural gene which is responsible for more than 94% of the 7S Ig H chain constant regions. In F1 hybrids with the genotype CS-1.1,1.3/CS-1.2, two populations of serum 7S Ig molecules were detected by direct and sequential binding analysis with specific alloantisera. One population of 7S Ig contained specificities CS-1.1 and CS-1.3, but not CS-1.2; while the second population carried only specificity CS-1.2. Therefore, each population was exclusively the product of one parental allele. Consistent with a genetic regulatory mechanism involving allelic exclusion, no 7S Ig containing allotypes produced by both alleles was detected." @default.
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- W4313339190 date "1977-02-01" @default.
- W4313339190 modified "2023-09-26" @default.
- W4313339190 title "Structural and Genetic Studies on Chicken 7S Immunoglobulin Allotypes" @default.
- W4313339190 doi "https://doi.org/10.4049/jimmunol.118.2.401" @default.
- W4313339190 hasPublicationYear "1977" @default.
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