FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313339504> ?p ?o ?g. }

• W4313339504 abstract "Glutamate dehydrogenase (Gdh), catalyzing the reversible conversion between 2-oxoglutarate and glutamate, plays an important role in the connection of nitrogen and carbon metabolism. Yet little is known about these enzymes in the amino acid-manufacturing Corynebacterium glutamicum. In the present study, we firstly identified the enzymatic characteristics of two Gdhs (GdhA and GdhB). The results showed that both GdhA and GdhB prefers NADPH as a coenzyme and have higher affinity for 2-OG than glutamate. The growth characteristics of gdhAΔ mutant and gdhBΔ mutant, gdhABΔ mutant showed GdhA serves as the main conduit for ammonium assimilation, and GdhB is the main glutamate- metabolizing enzyme in C. glutamicum. The full-genome transcriptomic analysis was used to investigate physiological response of C. glutamicum to the glutamate as nitrogen source, and gdh deletion. The results showed that the nitrogen starvation response was elicited when glutamine served as the sole nitrogen source. gdhAΔBΔ double deletion trigger a partially deregulated nitrogen starvation response, in which genes involved in nitrogen assimilation showed obviously upregulated in a certain extent. On the other hand, the genes of phosphotransferase system (PTS) and glycolysis pathway, most genes in pentose phosphate pathway were significantly upregulated, indicating that gdh deficiency initiated the enhancement of the absorption and metabolism of carbon sources. We believed that our results in this study will give new insights on the molecular mechanism of Gdh activity cross-talks with carbon and nitrogen metabolism, also setting a new background for further flux redistribution applied research of biotechnological interest." @default.
• W4313339504 created "2023-01-06" @default.
• W4313339504 creator A5000357073 @default.
• W4313339504 creator A5001902525 @default.
• W4313339504 creator A5029009431 @default.
• W4313339504 creator A5029117664 @default.
• W4313339504 creator A5039926801 @default.
• W4313339504 creator A5061581981 @default.
• W4313339504 creator A5063922467 @default.
• W4313339504 date "2022-12-28" @default.
• W4313339504 modified "2023-10-18" @default.
• W4313339504 title "Transcriptomic and enzymatic analysis reveals the roles of glutamate dehydrogenase in Corynebacterium glutamicum" @default.
• W4313339504 cites W1792013672 @default.
• W4313339504 cites W1855951655 @default.
• W4313339504 cites W1970883388 @default.
• W4313339504 cites W1991827599 @default.
• W4313339504 cites W1998096298 @default.
• W4313339504 cites W1999574084 @default.
• W4313339504 cites W2004235182 @default.
• W4313339504 cites W2020332438 @default.
• W4313339504 cites W2025292642 @default.
• W4313339504 cites W2048328866 @default.
• W4313339504 cites W2053402249 @default.
• W4313339504 cites W2058246421 @default.
• W4313339504 cites W2072278470 @default.
• W4313339504 cites W2096376234 @default.
• W4313339504 cites W2105106534 @default.
• W4313339504 cites W2107060225 @default.
• W4313339504 cites W2111221302 @default.
• W4313339504 cites W2115197840 @default.
• W4313339504 cites W2115955917 @default.
• W4313339504 cites W2117669771 @default.
• W4313339504 cites W2143521363 @default.
• W4313339504 cites W2143984655 @default.
• W4313339504 cites W2152239989 @default.
• W4313339504 cites W2153076508 @default.
• W4313339504 cites W2161546116 @default.
• W4313339504 cites W2167707678 @default.
• W4313339504 cites W2321758554 @default.
• W4313339504 cites W2365011386 @default.
• W4313339504 cites W2412487033 @default.
• W4313339504 cites W2579922223 @default.
• W4313339504 cites W2613114374 @default.
• W4313339504 cites W2802287279 @default.
• W4313339504 cites W2980534943 @default.
• W4313339504 cites W3005745912 @default.
• W4313339504 cites W3012645296 @default.
• W4313339504 cites W3044113060 @default.
• W4313339504 cites W3126512004 @default.
• W4313339504 cites W3133146996 @default.
• W4313339504 cites W3142253928 @default.
• W4313339504 cites W319903146 @default.
• W4313339504 cites W3199339864 @default.
• W4313339504 cites W4200325153 @default.
• W4313339504 cites W4225650071 @default.
• W4313339504 doi "https://doi.org/10.1186/s13568-022-01506-7" @default.
• W4313339504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36576637" @default.
• W4313339504 hasPublicationYear "2022" @default.
• W4313339504 type Work @default.
• W4313339504 citedByCount "0" @default.
• W4313339504 crossrefType "journal-article" @default.
• W4313339504 hasAuthorship W4313339504A5000357073 @default.
• W4313339504 hasAuthorship W4313339504A5001902525 @default.
• W4313339504 hasAuthorship W4313339504A5029009431 @default.
• W4313339504 hasAuthorship W4313339504A5029117664 @default.
• W4313339504 hasAuthorship W4313339504A5039926801 @default.
• W4313339504 hasAuthorship W4313339504A5061581981 @default.
• W4313339504 hasAuthorship W4313339504A5063922467 @default.
• W4313339504 hasBestOaLocation W43133395041 @default.
• W4313339504 hasConcept C104317684 @default.
• W4313339504 hasConcept C150194340 @default.
• W4313339504 hasConcept C160403918 @default.
• W4313339504 hasConcept C162317418 @default.
• W4313339504 hasConcept C170493617 @default.
• W4313339504 hasConcept C181199279 @default.
• W4313339504 hasConcept C191771488 @default.
• W4313339504 hasConcept C192989942 @default.
• W4313339504 hasConcept C20251656 @default.
• W4313339504 hasConcept C2776260651 @default.
• W4313339504 hasConcept C2777202666 @default.
• W4313339504 hasConcept C2779289688 @default.
• W4313339504 hasConcept C2779349466 @default.
• W4313339504 hasConcept C3119751 @default.
• W4313339504 hasConcept C3409486 @default.
• W4313339504 hasConcept C515207424 @default.
• W4313339504 hasConcept C553450214 @default.
• W4313339504 hasConcept C55493867 @default.
• W4313339504 hasConcept C61174792 @default.
• W4313339504 hasConcept C62231903 @default.
• W4313339504 hasConcept C86803240 @default.
• W4313339504 hasConceptScore W4313339504C104317684 @default.
• W4313339504 hasConceptScore W4313339504C150194340 @default.
• W4313339504 hasConceptScore W4313339504C160403918 @default.
• W4313339504 hasConceptScore W4313339504C162317418 @default.
• W4313339504 hasConceptScore W4313339504C170493617 @default.
• W4313339504 hasConceptScore W4313339504C181199279 @default.
• W4313339504 hasConceptScore W4313339504C191771488 @default.
• W4313339504 hasConceptScore W4313339504C192989942 @default.
• W4313339504 hasConceptScore W4313339504C20251656 @default.
• W4313339504 hasConceptScore W4313339504C2776260651 @default.

• next