Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313339539> ?p ?o ?g. }
- W4313339539 endingPage "613" @default.
- W4313339539 startingPage "602" @default.
- W4313339539 abstract "Peripheral nerve injury is a clinical problem that may cause sensory and motor inabilities. Sesamol is an antioxidant that can help in repairing damaged central nervous system (CNS) and other organs. The present study aimed to investigate whether the antioxidant effects of sesamol could improve the function, structure, and myelination in rats' damaged peripheral nervous system (PNS).In this study, 28 adult male Wistar rats were randomly divided into four groups. In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. The control received DMSO (solvent) and the two experimental groups received 50 or 100 mg/kg sesamol intraperitoneally for 28 days after sciatic nerve crush injury, respectively. Next, sciatic function index (SFI), superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, expression of nerve growth factor (NGF) and myelin protein zero (MPZ) proteins in the sciatic nerve, and histological indices of the sciatic nerve and gastrocnemius muscle were evaluated.The results showed that sesamol reduced oxidative stress parameters, increased expression of NGF and MPZ proteins, and improved function and regeneration of the damaged sciatic nerve. Furthermore, a significant regeneration was observed in the gastrocnemius muscle after treatment with sesamol. Although administration of both doses of sesamol was useful, the 100 mg/kg dose was more effective than the 50 mg/kg one.The results suggest that sesamol may be effective in improving damaged peripheral nerves in rats by reducing oxidative stress and increasing the expression of NGF and MPZ proteins." @default.
- W4313339539 created "2023-01-06" @default.
- W4313339539 creator A5006263935 @default.
- W4313339539 creator A5011748191 @default.
- W4313339539 creator A5018861424 @default.
- W4313339539 creator A5019461759 @default.
- W4313339539 creator A5030326715 @default.
- W4313339539 creator A5073501559 @default.
- W4313339539 creator A5079461805 @default.
- W4313339539 creator A5083880366 @default.
- W4313339539 creator A5091793000 @default.
- W4313339539 date "2022-12-31" @default.
- W4313339539 modified "2023-09-29" @default.
- W4313339539 title "Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters." @default.
- W4313339539 cites W1898091639 @default.
- W4313339539 cites W1985928156 @default.
- W4313339539 cites W1991333537 @default.
- W4313339539 cites W2003185937 @default.
- W4313339539 cites W2004842548 @default.
- W4313339539 cites W2017194107 @default.
- W4313339539 cites W2046328818 @default.
- W4313339539 cites W2049421422 @default.
- W4313339539 cites W2100746888 @default.
- W4313339539 cites W2100976863 @default.
- W4313339539 cites W2108379611 @default.
- W4313339539 cites W2128635872 @default.
- W4313339539 cites W2136807038 @default.
- W4313339539 cites W2142922236 @default.
- W4313339539 cites W2149175569 @default.
- W4313339539 cites W2164700578 @default.
- W4313339539 cites W2281525046 @default.
- W4313339539 cites W2298492972 @default.
- W4313339539 cites W2472054490 @default.
- W4313339539 cites W2520877546 @default.
- W4313339539 cites W2550260150 @default.
- W4313339539 cites W2596256039 @default.
- W4313339539 cites W2622249127 @default.
- W4313339539 cites W2624760628 @default.
- W4313339539 cites W274009491 @default.
- W4313339539 cites W2744786175 @default.
- W4313339539 cites W2790082354 @default.
- W4313339539 cites W2801025021 @default.
- W4313339539 cites W2802185384 @default.
- W4313339539 cites W2883424318 @default.
- W4313339539 cites W2897520789 @default.
- W4313339539 cites W2953936789 @default.
- W4313339539 cites W2979464762 @default.
- W4313339539 cites W2991168939 @default.
- W4313339539 cites W2998634777 @default.
- W4313339539 cites W3008197203 @default.
- W4313339539 cites W3011377678 @default.
- W4313339539 cites W3012338945 @default.
- W4313339539 cites W3023248923 @default.
- W4313339539 cites W3034746533 @default.
- W4313339539 cites W3035443750 @default.
- W4313339539 cites W3091854904 @default.
- W4313339539 cites W3107370084 @default.
- W4313339539 cites W3111962953 @default.
- W4313339539 cites W3119156420 @default.
- W4313339539 cites W882806104 @default.
- W4313339539 doi "https://doi.org/10.22038/ajp.2022.20663" @default.
- W4313339539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583179" @default.
- W4313339539 hasPublicationYear "2022" @default.
- W4313339539 type Work @default.
- W4313339539 citedByCount "0" @default.
- W4313339539 crossrefType "journal-article" @default.
- W4313339539 hasAuthorship W4313339539A5006263935 @default.
- W4313339539 hasAuthorship W4313339539A5011748191 @default.
- W4313339539 hasAuthorship W4313339539A5018861424 @default.
- W4313339539 hasAuthorship W4313339539A5019461759 @default.
- W4313339539 hasAuthorship W4313339539A5030326715 @default.
- W4313339539 hasAuthorship W4313339539A5073501559 @default.
- W4313339539 hasAuthorship W4313339539A5079461805 @default.
- W4313339539 hasAuthorship W4313339539A5083880366 @default.
- W4313339539 hasAuthorship W4313339539A5091793000 @default.
- W4313339539 hasConcept C126322002 @default.
- W4313339539 hasConcept C134018914 @default.
- W4313339539 hasConcept C141071460 @default.
- W4313339539 hasConcept C170493617 @default.
- W4313339539 hasConcept C185592680 @default.
- W4313339539 hasConcept C2775838275 @default.
- W4313339539 hasConcept C2775872116 @default.
- W4313339539 hasConcept C2776151105 @default.
- W4313339539 hasConcept C2776880756 @default.
- W4313339539 hasConcept C2777107032 @default.
- W4313339539 hasConcept C2778004101 @default.
- W4313339539 hasConcept C2778401633 @default.
- W4313339539 hasConcept C2778407507 @default.
- W4313339539 hasConcept C2778423431 @default.
- W4313339539 hasConcept C2779959927 @default.
- W4313339539 hasConcept C2781149210 @default.
- W4313339539 hasConcept C42219234 @default.
- W4313339539 hasConcept C529278444 @default.
- W4313339539 hasConcept C545314008 @default.
- W4313339539 hasConcept C55493867 @default.
- W4313339539 hasConcept C71924100 @default.
- W4313339539 hasConcept C98274493 @default.
- W4313339539 hasConceptScore W4313339539C126322002 @default.