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• W4313339544 abstract "Abstract Fatty acids (FAs) are well known to serve as substrates for reactions that provide cells with membranes and energy. In contrast to these metabolic reactions, the physiological importance of FAs themselves known as free FAs (FFAs) in cells remains obscure. Since accumulation of FFAs in cells is toxic, cells must develop mechanisms to detoxify FFAs. One such mechanism is to sequester free polyunsaturated FAs (PUFAs) into a droplet‐like structure assembled by Fas‐Associated Factor 1 (FAF1), a cytosolic protein. This sequestration limits access of PUFAs to Fe 2+ , thereby preventing Fe 2+ ‐catalyzed PUFA peroxidation. Consequently, assembly of the FAF1‐FFA complex is critical to protect cells from ferroptosis, a cell death pathway triggered by PUFA peroxidation. The observations that free PUFAs in cytosol are not randomly diffused but rather sequestered into a membraneless complex should open new directions to explore signaling pathways by which FFAs regulate cellular physiology." @default.
• W4313339544 created "2023-01-06" @default.
• W4313339544 creator A5041961168 @default.
• W4313339544 creator A5076126914 @default.
• W4313339544 date "2022-12-30" @default.
• W4313339544 modified "2023-09-26" @default.
• W4313339544 title "A protein‐lipid complex that detoxifies free fatty acids" @default.
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• W4313339544 doi "https://doi.org/10.1002/bies.202200210" @default.
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