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- W4313339903 abstract "Neural tube defects (NTDs) remain among the most common congenital anomalies. Contributing risk factors include genetics and nutrient deficiencies, however, a comprehensive assessment of nutrient-gene interactions in NTDs is lacking. We applied a nutrient-focused gene expression analysis pipeline to identify nutrient-sensitive gene regulatory networks in amniocyte gene expression data (GSE4182) from fetuses with NTDs (cases; n = 3) and fetuses with no congenital anomalies (controls; n = 5). Differentially expressed genes (DEGs) were screened for having nutrient cofactors. Nutrient-dependent transcriptional regulators (TRs) that regulated DEGs, and nutrient-sensitive miRNAs with a previous link to NTDs, were identified. Of the 880 DEGs in cases, 10% had at least one nutrient cofactor. DEG regulatory network analysis revealed that 39% and 52% of DEGs in cases were regulated by 22 nutrient-sensitive miRNAs and 10 nutrient-dependent TRs, respectively. Zinc- and B vitamin-dependent gene regulatory networks (Zinc: 10 TRs targeting 50.6% of DEGs; B vitamins: 4 TRs targeting 37.7% of DEGs, 9 miRNAs targeting 17.6% of DEGs) were dysregulated in cases. We identified novel, nutrient-sensitive gene regulatory networks not previously linked to NTDs, which may indicate new targets to explore for NTD prevention or to optimise fetal development." @default.
- W4313339903 created "2023-01-06" @default.
- W4313339903 creator A5077589365 @default.
- W4313339903 creator A5090216631 @default.
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- W4313339903 date "2023-03-01" @default.
- W4313339903 modified "2023-10-18" @default.
- W4313339903 title "Identification of novel nutrient-sensitive gene regulatory networks in amniocytes from fetuses with spina bifida" @default.
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- W4313339903 doi "https://doi.org/10.1016/j.reprotox.2022.12.010" @default.
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- W4313339903 hasPublicationYear "2023" @default.
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