FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313339954> ?p ?o ?g. }

• W4313339954 endingPage "184" @default.
• W4313339954 startingPage "175" @default.
• W4313339954 abstract "Dantrolene (DAN) directly binds to cardiac ryanodine receptor 2 (RyR2) through Leu601–Cys620 in the N-terminal domain and subsequently inhibits diastolic Ca2+ leakage through RyR2. We previously reported that therapy using RyR2 V3599K mutation, which inhibits diastolic Ca2+ leakage by enhancing calmodulin (CaM) binding ability to RyR2, prevents left ventricular (LV) remodeling in transverse aortic constriction (TAC) heart failure. Here, we examined whether chronic administration of DAN prevents LV remodeling in TAC heart failure via the same mechanism as genetic therapy. A pressure-overloaded hypertrophy mouse model was developed using TAC. Wild-type (WT) mice were divided into three groups: sham-operated mice (Sham group), TAC mice (TAC group), and TAC mice treated with DAN (TAC-DAN group, 20 mg/kg/day, i.p.). They were then followed up for 8 weeks. The survival rate was higher in the TAC-DAN group (83%) than in the TAC group (49%), and serial echocardiography studies and pathological tissue analysis showed that LV remodeling was significantly prevented in the TAC-DAN group compared to the TAC group. An increase in the diastolic Ca2+ spark frequency and a decrease in the binding affinity of CaM to RyR2 were observed at 8 weeks in the TAC group but not in the TAC-DAN group. Stabilization of RyR2 with DAN prevented LV remodeling and improved survival after TAC by enhancing CaM binding to RyR2 and inhibiting RyR2-mediated diastolic Ca2+ leakage." @default.
• W4313339954 created "2023-01-06" @default.
• W4313339954 creator A5005553864 @default.
• W4313339954 creator A5005937607 @default.
• W4313339954 creator A5010155877 @default.
• W4313339954 creator A5021433405 @default.
• W4313339954 creator A5025325506 @default.
• W4313339954 creator A5037548640 @default.
• W4313339954 creator A5038658184 @default.
• W4313339954 creator A5063104353 @default.
• W4313339954 creator A5066255291 @default.
• W4313339954 creator A5068877810 @default.
• W4313339954 creator A5075462076 @default.
• W4313339954 creator A5080090682 @default.
• W4313339954 date "2023-01-01" @default.
• W4313339954 modified "2023-10-14" @default.
• W4313339954 title "Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice" @default.
• W4313339954 cites W1966781482 @default.
• W4313339954 cites W1970049184 @default.
• W4313339954 cites W1979057236 @default.
• W4313339954 cites W1991105198 @default.
• W4313339954 cites W1997939828 @default.
• W4313339954 cites W2022714275 @default.
• W4313339954 cites W2028487714 @default.
• W4313339954 cites W2075089321 @default.
• W4313339954 cites W2083049504 @default.
• W4313339954 cites W2118098701 @default.
• W4313339954 cites W2126324760 @default.
• W4313339954 cites W2136098553 @default.
• W4313339954 cites W2140152140 @default.
• W4313339954 cites W2148269081 @default.
• W4313339954 cites W2148376568 @default.
• W4313339954 cites W2159514656 @default.
• W4313339954 cites W2433829330 @default.
• W4313339954 cites W2536737644 @default.
• W4313339954 cites W2949007780 @default.
• W4313339954 cites W2980397765 @default.
• W4313339954 cites W2995661658 @default.
• W4313339954 cites W3110607973 @default.
• W4313339954 cites W4210245099 @default.
• W4313339954 cites W4233503959 @default.
• W4313339954 cites W4255760410 @default.
• W4313339954 cites W4302009679 @default.
• W4313339954 doi "https://doi.org/10.1016/j.bbrc.2022.12.063" @default.
• W4313339954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36584481" @default.
• W4313339954 hasPublicationYear "2023" @default.
• W4313339954 type Work @default.
• W4313339954 citedByCount "2" @default.
• W4313339954 countsByYear W43133399542023 @default.
• W4313339954 crossrefType "journal-article" @default.
• W4313339954 hasAuthorship W4313339954A5005553864 @default.
• W4313339954 hasAuthorship W4313339954A5005937607 @default.
• W4313339954 hasAuthorship W4313339954A5010155877 @default.
• W4313339954 hasAuthorship W4313339954A5021433405 @default.
• W4313339954 hasAuthorship W4313339954A5025325506 @default.
• W4313339954 hasAuthorship W4313339954A5037548640 @default.
• W4313339954 hasAuthorship W4313339954A5038658184 @default.
• W4313339954 hasAuthorship W4313339954A5063104353 @default.
• W4313339954 hasAuthorship W4313339954A5066255291 @default.
• W4313339954 hasAuthorship W4313339954A5068877810 @default.
• W4313339954 hasAuthorship W4313339954A5075462076 @default.
• W4313339954 hasAuthorship W4313339954A5080090682 @default.
• W4313339954 hasConcept C113217602 @default.
• W4313339954 hasConcept C126322002 @default.
• W4313339954 hasConcept C134018914 @default.
• W4313339954 hasConcept C164705383 @default.
• W4313339954 hasConcept C167414201 @default.
• W4313339954 hasConcept C170493617 @default.
• W4313339954 hasConcept C190712762 @default.
• W4313339954 hasConcept C26635844 @default.
• W4313339954 hasConcept C2776002628 @default.
• W4313339954 hasConcept C2778198053 @default.
• W4313339954 hasConcept C2778271984 @default.
• W4313339954 hasConcept C2779537366 @default.
• W4313339954 hasConcept C2781460320 @default.
• W4313339954 hasConcept C3018791406 @default.
• W4313339954 hasConcept C519063684 @default.
• W4313339954 hasConcept C57900726 @default.
• W4313339954 hasConcept C71924100 @default.
• W4313339954 hasConcept C84393581 @default.
• W4313339954 hasConceptScore W4313339954C113217602 @default.
• W4313339954 hasConceptScore W4313339954C126322002 @default.
• W4313339954 hasConceptScore W4313339954C134018914 @default.
• W4313339954 hasConceptScore W4313339954C164705383 @default.
• W4313339954 hasConceptScore W4313339954C167414201 @default.
• W4313339954 hasConceptScore W4313339954C170493617 @default.
• W4313339954 hasConceptScore W4313339954C190712762 @default.
• W4313339954 hasConceptScore W4313339954C26635844 @default.
• W4313339954 hasConceptScore W4313339954C2776002628 @default.
• W4313339954 hasConceptScore W4313339954C2778198053 @default.
• W4313339954 hasConceptScore W4313339954C2778271984 @default.
• W4313339954 hasConceptScore W4313339954C2779537366 @default.
• W4313339954 hasConceptScore W4313339954C2781460320 @default.
• W4313339954 hasConceptScore W4313339954C3018791406 @default.
• W4313339954 hasConceptScore W4313339954C519063684 @default.
• W4313339954 hasConceptScore W4313339954C57900726 @default.
• W4313339954 hasConceptScore W4313339954C71924100 @default.
• W4313339954 hasConceptScore W4313339954C84393581 @default.

• next