Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313339955> ?p ?o ?g. }
- W4313339955 endingPage "100179" @default.
- W4313339955 startingPage "100179" @default.
- W4313339955 abstract "Intracellular Ca2+ mobilization induced by second messenger IP3 controls many cellular events in most of the eukaryotic groups. Despite the increasing evidence of IP3-induced Ca2+ in apicomplexan parasites like Plasmodium, responsible for malaria infection, no protein with potential function as an IP3-receptor has been identified. The use of bioinformatic analyses based on previously known sequences of IP3-receptor failed to identify potential IP3-receptor candidates in any Apicomplexa. In this work, we combine the biochemical approach of an IP3 affinity chromatography column with bioinformatic meta-analyses to identify potential vital membrane proteins that present binding with IP3 in Plasmodium falciparum. Our analyses reveal that PF3D7_0523000, a gene that codes a transport protein associated with multidrug resistance as a potential target for IP3. This work provides a new insight for probing potential candidates for IP3-receptor in Apicomplexa." @default.
- W4313339955 created "2023-01-06" @default.
- W4313339955 creator A5010775051 @default.
- W4313339955 creator A5031848109 @default.
- W4313339955 creator A5073122400 @default.
- W4313339955 creator A5087504708 @default.
- W4313339955 date "2023-01-01" @default.
- W4313339955 modified "2023-09-27" @default.
- W4313339955 title "Combining IP3 affinity chromatography and bioinformatics reveals a novel protein-IP3 binding site on Plasmodium falciparum MDR1 transporter" @default.
- W4313339955 cites W1507908059 @default.
- W4313339955 cites W1568062575 @default.
- W4313339955 cites W1598199924 @default.
- W4313339955 cites W1969503178 @default.
- W4313339955 cites W1972177048 @default.
- W4313339955 cites W1972210156 @default.
- W4313339955 cites W1973459107 @default.
- W4313339955 cites W1986226514 @default.
- W4313339955 cites W1986325478 @default.
- W4313339955 cites W1988408916 @default.
- W4313339955 cites W1988664870 @default.
- W4313339955 cites W1989421050 @default.
- W4313339955 cites W1992283207 @default.
- W4313339955 cites W1993828237 @default.
- W4313339955 cites W1994981343 @default.
- W4313339955 cites W2003011332 @default.
- W4313339955 cites W2003380001 @default.
- W4313339955 cites W2008166606 @default.
- W4313339955 cites W2008245136 @default.
- W4313339955 cites W2008726042 @default.
- W4313339955 cites W2017821732 @default.
- W4313339955 cites W2019851585 @default.
- W4313339955 cites W2021533268 @default.
- W4313339955 cites W2023910665 @default.
- W4313339955 cites W2026925546 @default.
- W4313339955 cites W2028656069 @default.
- W4313339955 cites W2030217314 @default.
- W4313339955 cites W2030631891 @default.
- W4313339955 cites W2035857560 @default.
- W4313339955 cites W2036145275 @default.
- W4313339955 cites W2036221112 @default.
- W4313339955 cites W2037350416 @default.
- W4313339955 cites W2043988543 @default.
- W4313339955 cites W2060809301 @default.
- W4313339955 cites W2062963197 @default.
- W4313339955 cites W2068877244 @default.
- W4313339955 cites W2074137197 @default.
- W4313339955 cites W2075034746 @default.
- W4313339955 cites W2076710561 @default.
- W4313339955 cites W2083860481 @default.
- W4313339955 cites W2085474187 @default.
- W4313339955 cites W2085513237 @default.
- W4313339955 cites W2093915276 @default.
- W4313339955 cites W2096483998 @default.
- W4313339955 cites W2097263871 @default.
- W4313339955 cites W2100265629 @default.
- W4313339955 cites W2101078720 @default.
- W4313339955 cites W2112017417 @default.
- W4313339955 cites W2115397795 @default.
- W4313339955 cites W2122306218 @default.
- W4313339955 cites W2127020680 @default.
- W4313339955 cites W2131294770 @default.
- W4313339955 cites W2132629607 @default.
- W4313339955 cites W2138754677 @default.
- W4313339955 cites W2140104591 @default.
- W4313339955 cites W2150861334 @default.
- W4313339955 cites W2152770371 @default.
- W4313339955 cites W2154248614 @default.
- W4313339955 cites W2159675211 @default.
- W4313339955 cites W2160778580 @default.
- W4313339955 cites W2162503845 @default.
- W4313339955 cites W2187175790 @default.
- W4313339955 cites W2587116348 @default.
- W4313339955 cites W2791292782 @default.
- W4313339955 cites W2800834635 @default.
- W4313339955 cites W2889803626 @default.
- W4313339955 cites W2951778995 @default.
- W4313339955 cites W2965021553 @default.
- W4313339955 cites W3080525210 @default.
- W4313339955 cites W3090016913 @default.
- W4313339955 cites W68899276 @default.
- W4313339955 doi "https://doi.org/10.1016/j.crmicr.2022.100179" @default.
- W4313339955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36582189" @default.
- W4313339955 hasPublicationYear "2023" @default.
- W4313339955 type Work @default.
- W4313339955 citedByCount "2" @default.
- W4313339955 countsByYear W43133399552023 @default.
- W4313339955 crossrefType "journal-article" @default.
- W4313339955 hasAuthorship W4313339955A5010775051 @default.
- W4313339955 hasAuthorship W4313339955A5031848109 @default.
- W4313339955 hasAuthorship W4313339955A5073122400 @default.
- W4313339955 hasAuthorship W4313339955A5087504708 @default.
- W4313339955 hasBestOaLocation W43133399551 @default.
- W4313339955 hasConcept C104317684 @default.
- W4313339955 hasConcept C136764020 @default.
- W4313339955 hasConcept C149011108 @default.
- W4313339955 hasConcept C152624196 @default.
- W4313339955 hasConcept C170493617 @default.
- W4313339955 hasConcept C179247698 @default.