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- W4313339982 endingPage "102869" @default.
- W4313339982 startingPage "102869" @default.
- W4313339982 abstract "The prospect of leveraging naturally occurring phenotypes to overcome bottlenecks constraining the bioeconomy has marshalled increased exploration of nonconventional organisms. This review discusses the status of non-model eukaryotic species in bioproduction, the evaluation criteria for effectively matching a candidate host to a biosynthetic process, and the genetic engineering tools needed for host domestication. We present breakthroughs in genome editing and heterologous pathway design, delving into innovative spatiotemporal modulation strategies that potentiate more refined engineering capabilities. We cover current understanding of genetic instability and its ramifications for industrial scale-up, highlighting key factors and possible remedies. Finally, we propose future opportunities to expand the current collection of available hosts and provide guidance to benefit the broader bioeconomy." @default.
- W4313339982 created "2023-01-06" @default.
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- W4313339982 date "2023-02-01" @default.
- W4313339982 modified "2023-10-10" @default.
- W4313339982 title "Engineering of non-model eukaryotes for bioenergy and biochemical production" @default.
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- W4313339982 doi "https://doi.org/10.1016/j.copbio.2022.102869" @default.
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- W4313339982 hasPublicationYear "2023" @default.
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