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• W4313340249 startingPage "154289" @default.
• W4313340249 abstract "Tumor-infiltrating lymphocytes (TILs) are important prognostic biomarkers in several types of cancers. The interplay between TIL subgroups and immune checkpoint molecules like programmed cell death ligand 1 (PD-L1) is a promising target for immunotherapy. However, the TIL landscape in sinonasal mucosal melanoma (SNMM) has not been sufficiently characterized yet and the prognostic value of TIL subgroups and PD-L1 expression remains uncertain. Here, we investigated subsets of TILs (CD3+, CD4+, CD8+, CD20+) and PD-L1 expression patterns in SNMM and assessed their prognostic value for recurrence-free and overall survival.Immunohistochemical staining for CD3, CD4, CD8, CD20 and PD-L1 was performed on tumor tissue from 27 patients with primary SNMM. Patient history was obtained and associations between TIL subgroups or PD-L1 expression and AJCC tumor stage, overall survival, and recurrence-free survival were retrospectively analyzed.Patients with high CD3+ and CD8+ TILs in the primary tumor survived significantly longer than patients with SNMMs with a low number of CD3+ and CD8+ TILs. High CD3+ and high CD8+ TILs were associated with the lower T3 stage and increased 5-year survival. PD-L1 positivity in tumor cells was associated with advanced tumor stage.Our results indicate that high densities of CD3+ and CD8+ TILs are strong positive prognostic biomarkers for survival in SNMM. Prospective studies with larger case numbers are warranted to confirm our findings." @default.
• W4313340249 created "2023-01-06" @default.
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• W4313340249 date "2023-01-01" @default.
• W4313340249 modified "2023-09-27" @default.
• W4313340249 title "Characterization of the tumor-infiltrating lymphocyte landscape in sinonasal mucosal melanoma" @default.
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• W4313340249 doi "https://doi.org/10.1016/j.prp.2022.154289" @default.
• W4313340249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36584498" @default.
• W4313340249 hasPublicationYear "2023" @default.
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