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• W4313341336 startingPage "360" @default.
• W4313341336 abstract "Abstract Pneumocystis carinii pneumonia is an important cause of morbidity and mortality in immunosuppressed patients, particularly HIV-infected individuals. An improved understanding of pulmonary host response, including the cytokines required for defense, could suggest novel immunotherapeutic approaches to this infection. The cytokines IFN-γ and TNF have contributory roles in host defense against P. carinii, but their combined and interactive importance is unclear. To test the roles of these cytokines in defense against P. carinii directly, organisms were inoculated intratracheally into wild-type mice and into three groups of gene-deleted mice: those lacking genes for IFN-γ (IFN-γ−/−), for TNF receptors 1 and 2 (TNFR−/−), and for both IFN-γ and TNFR (TNFR-IFN-γ−/−). Four weeks after P. carinii inoculation, lungs of the wild-type, IFN-γ−/−, and TNFR−/− mice demonstrated clearance of P. carinii and only mild inflammation. However, TNFR-IFN-γ−/− mice demonstrated severe P. carinii infection and lung inflammation. Our findings demonstrate conclusively that deletion of either IFN-γ or TNF activity alone does not block clearance of P. carinii. However, simultaneous deletion of IFN-γ and TNF receptor genes results in susceptibility to P. carinii. Rather than focusing exclusively on individual cytokines, our data suggest that immunotherapy targeted at maximizing both the IFN-γ and TNF responses to P. carinii may be required to augment host defense against this important opportunistic pathogen." @default.
• W4313341336 created "2023-01-06" @default.
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• W4313341336 date "1998-07-01" @default.
• W4313341336 modified "2023-10-05" @default.
• W4313341336 title "Susceptibility to <i>Pneumocystis carinii</i> in Mice Is Dependent on Simultaneous Deletion of IFN-γ and Type 1 and 2 TNF Receptor Genes" @default.
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• W4313341336 doi "https://doi.org/10.4049/jimmunol.161.1.360" @default.
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