Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313341503> ?p ?o ?g. }
- W4313341503 endingPage "2072" @default.
- W4313341503 startingPage "2064" @default.
- W4313341503 abstract "Abstract Recent data indicate that integrin-generated signals can modulate different receptor-stimulated cell functions in both a positive (costimulation) and a negative (inhibition) fashion. Here we investigated the ability of β1 integrins, namely α4β1 and α5β1 fibronectin receptors, to modulate CD16-triggered phospholipase activation in human NK cells. β1 integrin simultaneous cross-linking selectively inhibited CD16-induced phospholipase D (PLD) activation, without affecting either phosphatidylinositol-phospholipase C or cytosolic phospholipase A2 (PLA2) enzymatic activity. CD16-induced secretory PLA2 (sPLA2) protein release as well as its enzymatic activity in both cell-associated and soluble forms were also found to be inhibited upon β1 integrin coengagement. The similar effects exerted by specific PLD pharmacological inhibitors (2,3-diphosphoglycerate, ethanol) suggest that in our experimental system, sPLA2 secretion and activation are under the control of a PLD-dependent pathway. By using pharmacological inhibitors (2,3-diphosphoglycerate, wortmannin, ethanol) we also demonstrated that PLD activation is an important step in the CD16-triggered signaling cascade that leads to NK cytotoxic granule exocytosis. Consistent with these findings, fibronectin receptor engagement, by either mAbs or natural ligands, resulted in a selective inhibition of CD16-triggered, but not of PMA/ionomycin-induced, degranulation that was reversed by the exogenous addition of purified PLD from Streptomyces chromofuscus." @default.
- W4313341503 created "2023-01-06" @default.
- W4313341503 creator A5017694699 @default.
- W4313341503 creator A5023848359 @default.
- W4313341503 creator A5024871281 @default.
- W4313341503 creator A5027525394 @default.
- W4313341503 creator A5034150582 @default.
- W4313341503 creator A5045719432 @default.
- W4313341503 creator A5055250426 @default.
- W4313341503 creator A5058039141 @default.
- W4313341503 creator A5077762166 @default.
- W4313341503 date "1999-02-15" @default.
- W4313341503 modified "2023-10-16" @default.
- W4313341503 title "β1 Integrin Cross-Linking Inhibits CD16-Induced Phospholipase D and Secretory Phospholipase A2 Activity and Granule Exocytosis in Human NK cells: Role of Phospholipase D in CD16-Triggered Degranulation" @default.
- W4313341503 cites W1499222468 @default.
- W4313341503 cites W1556867369 @default.
- W4313341503 cites W1560606266 @default.
- W4313341503 cites W1569476889 @default.
- W4313341503 cites W1573713409 @default.
- W4313341503 cites W1574294745 @default.
- W4313341503 cites W1579433716 @default.
- W4313341503 cites W1580046657 @default.
- W4313341503 cites W1580196810 @default.
- W4313341503 cites W1580579112 @default.
- W4313341503 cites W1589558320 @default.
- W4313341503 cites W1601836864 @default.
- W4313341503 cites W1937597488 @default.
- W4313341503 cites W1957842281 @default.
- W4313341503 cites W1961309428 @default.
- W4313341503 cites W1990173454 @default.
- W4313341503 cites W1997584084 @default.
- W4313341503 cites W2006775012 @default.
- W4313341503 cites W2021406365 @default.
- W4313341503 cites W2029475575 @default.
- W4313341503 cites W2030655955 @default.
- W4313341503 cites W2031059672 @default.
- W4313341503 cites W2041338250 @default.
- W4313341503 cites W2050621406 @default.
- W4313341503 cites W2056206771 @default.
- W4313341503 cites W2059270957 @default.
- W4313341503 cites W2062904912 @default.
- W4313341503 cites W2066367871 @default.
- W4313341503 cites W2066791280 @default.
- W4313341503 cites W2071725107 @default.
- W4313341503 cites W2098908531 @default.
- W4313341503 cites W2101651865 @default.
- W4313341503 cites W2102431039 @default.
- W4313341503 cites W2102826707 @default.
- W4313341503 cites W2112569293 @default.
- W4313341503 cites W2112919363 @default.
- W4313341503 cites W2130691985 @default.
- W4313341503 cites W2139868649 @default.
- W4313341503 cites W2142351871 @default.
- W4313341503 cites W2147703120 @default.
- W4313341503 cites W2152311269 @default.
- W4313341503 cites W2167676805 @default.
- W4313341503 cites W2280573406 @default.
- W4313341503 cites W2282358619 @default.
- W4313341503 cites W2301107877 @default.
- W4313341503 cites W4319704852 @default.
- W4313341503 doi "https://doi.org/10.4049/jimmunol.162.4.2064" @default.
- W4313341503 hasPublicationYear "1999" @default.
- W4313341503 type Work @default.
- W4313341503 citedByCount "11" @default.
- W4313341503 countsByYear W43133415032022 @default.
- W4313341503 crossrefType "journal-article" @default.
- W4313341503 hasAuthorship W4313341503A5017694699 @default.
- W4313341503 hasAuthorship W4313341503A5023848359 @default.
- W4313341503 hasAuthorship W4313341503A5024871281 @default.
- W4313341503 hasAuthorship W4313341503A5027525394 @default.
- W4313341503 hasAuthorship W4313341503A5034150582 @default.
- W4313341503 hasAuthorship W4313341503A5045719432 @default.
- W4313341503 hasAuthorship W4313341503A5055250426 @default.
- W4313341503 hasAuthorship W4313341503A5058039141 @default.
- W4313341503 hasAuthorship W4313341503A5077762166 @default.
- W4313341503 hasBestOaLocation W43133415031 @default.
- W4313341503 hasConcept C170493617 @default.
- W4313341503 hasConcept C175969161 @default.
- W4313341503 hasConcept C185592680 @default.
- W4313341503 hasConcept C195687474 @default.
- W4313341503 hasConcept C2776989580 @default.
- W4313341503 hasConcept C49039625 @default.
- W4313341503 hasConcept C49802076 @default.
- W4313341503 hasConcept C55493867 @default.
- W4313341503 hasConcept C6182249 @default.
- W4313341503 hasConcept C62478195 @default.
- W4313341503 hasConcept C79879829 @default.
- W4313341503 hasConcept C86803240 @default.
- W4313341503 hasConcept C95444343 @default.
- W4313341503 hasConceptScore W4313341503C170493617 @default.
- W4313341503 hasConceptScore W4313341503C175969161 @default.
- W4313341503 hasConceptScore W4313341503C185592680 @default.
- W4313341503 hasConceptScore W4313341503C195687474 @default.
- W4313341503 hasConceptScore W4313341503C2776989580 @default.
- W4313341503 hasConceptScore W4313341503C49039625 @default.
- W4313341503 hasConceptScore W4313341503C49802076 @default.
- W4313341503 hasConceptScore W4313341503C55493867 @default.
- W4313341503 hasConceptScore W4313341503C6182249 @default.