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• W4313342316 abstract "AbstractThe enteric nervous system (ENS) is required for many cyclical patterns of motor activity along different regions of the gastrointestinal (GI) tract. What has remained mysterious is precisely how many thousands of neurons within the ENS are temporally activated to generate cyclical neurogenic contractions of GI-smooth muscle layers. This has been an especially puzzling conundrum, since the ENS consists of an extensive network of small ganglia, with each ganglion consisting of a heterogeneous population of neurons, with diverse cell soma morphologies, neurochemical and biophysical characteristics, and neural connectivity. Neuronal imaging studies of the mouse large intestine have provided major new insights into how the different classes of myenteric neurons are activated during cyclical neurogenic motor patterns, such as the colonic motor complex (CMC). It has been revealed that during CMCs (in the isolated mouse whole colon), large populations of myenteric neurons, across large spatial fields, coordinate their firing, via bursts of fast synaptic inputs at ~2 Hz. This coordinated firing of many thousands of myenteric neurons synchronously over many rows of interconnected ganglia occurs irrespective of the functional class of neuron. Aborally directed propulsion of content along the mouse colon is due, in large part, to polarity of the enteric circuits including the projections of the intrinsic excitatory and inhibitory motor neurons but still involves the fundamental ~2 Hz rhythmic activity of specific classes of enteric neurons. What remains to be determined are the mechanisms that initiate and terminate the patterned firing of large ensembles of enteric neurons during cyclic activity. This remains an exciting challenge for future studies.KeywordsColonic motor complexPeristalsisColonEnteric nervous systemSensory neuronsPropulsionEnteric nervous system" @default.
• W4313342316 created "2023-01-06" @default.
• W4313342316 creator A5052605602 @default.
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• W4313342316 date "2022-01-01" @default.
• W4313342316 modified "2023-10-13" @default.
• W4313342316 title "Rhythmicity in the Enteric Nervous System of Mice" @default.
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• W4313342316 doi "https://doi.org/10.1007/978-3-031-05843-1_27" @default.
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• W4313342316 hasPublicationYear "2022" @default.
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