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- W4313343453 abstract "Abstract IL-15 has recently been detected in the synovium of patients with rheumatoid arthritis. IL-15-activated T cells induce significant TNF-α synthesis by macrophages via a cell contact-dependent mechanism, suggesting a key regulatory role for IL-15. Here, we report that the administration of a soluble fragment of IL-15Rα into DBA/1 mice, profoundly suppressed the development of collagen-induced arthritis. This was accompanied in vitro by marked reductions in Ag-specific proliferation and IFN-γ synthesis by spleen cells from treated mice compared with control mice and in vivo by a significant reduction in serum anti-collagen Ab levels. These data directly demonstrate a pivotal role for IL-15 in the development of inflammatory arthritis and also suggest that antagonists to IL-15 may have therapeutic potential in rheumatic diseases." @default.
- W4313343453 created "2023-01-06" @default.
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- W4313343453 date "1998-06-01" @default.
- W4313343453 modified "2023-10-17" @default.
- W4313343453 title "Soluble IL-15 Receptor α-Chain Administration Prevents Murine Collagen-Induced Arthritis: A Role for IL-15 in Development of Antigen-Induced Immunopathology" @default.
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- W4313343453 doi "https://doi.org/10.4049/jimmunol.160.11.5654" @default.
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