Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313343456> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313343456 endingPage "93.24" @default.
- W4313343456 startingPage "93.24" @default.
- W4313343456 abstract "Abstract Mechanisms of pathogenesis of brain autoantibodies are not well defined as to functional aspects and targets in disease. We utilized V genes of Sydenham chorea derived mAb to investigate crossreactive specificities and in vivo targets after expression in Tg mice. Novel human mAb 24.3.1, derived from group A streptococcal autoimmune sequela, targeted dopamine D1 and D2 receptors and reacted with group A streptococcal carbohydrate epitope N-acetyl-beta-D-glucosamine. Anti-neuronal brain specificities included lysoganglioside on neuronal cell surface and abundant intracellular brain protein tubulin. Human mAb 24.3.1 has been shown to induce signal transduction in neuronal cells with increased Ca++ calmodulin dependent protein kinase II. Expression of chimeric IgG1a antibody in Tg mouse sera conferred reactivity with D1/D2 dopamine receptors and led to deposition on dopaminergic neurons in vivo in Tg mouse brain. IgG1a transgene was detected in vivo and in vitro with anti-allotypic antibodies against IgG1a. Immunofluorescent co-localization of allotype specific Tg antibodies and tyrosine hydroxylase demonstrated chimeric IgG1a 24.3.1 deposited and bound to dopaminergic neurons in Tg mouse brain in vivo. Tg sera and IgG1a reacted with neuronal antigens lysoganglioside, tubulin and dopamine receptors D1/D2. Our data support the hypothesis that in human disease, antibodies may bind neurons and alter brain function to induce movement and behavioral disorders such as SC and PANDAS." @default.
- W4313343456 created "2023-01-06" @default.
- W4313343456 creator A5024828248 @default.
- W4313343456 creator A5026595384 @default.
- W4313343456 date "2010-04-01" @default.
- W4313343456 modified "2023-09-23" @default.
- W4313343456 title "Sydenham Chorea-derived brain autoantibody expressed in transgenic (Tg) mice targets dopaminergic neurons and reveals crossreactive anti-neuronal specificities. (93.24)" @default.
- W4313343456 doi "https://doi.org/10.4049/jimmunol.184.supp.93.24" @default.
- W4313343456 hasPublicationYear "2010" @default.
- W4313343456 type Work @default.
- W4313343456 citedByCount "0" @default.
- W4313343456 crossrefType "journal-article" @default.
- W4313343456 hasAuthorship W4313343456A5024828248 @default.
- W4313343456 hasAuthorship W4313343456A5026595384 @default.
- W4313343456 hasConcept C126322002 @default.
- W4313343456 hasConcept C137183658 @default.
- W4313343456 hasConcept C150903083 @default.
- W4313343456 hasConcept C153911025 @default.
- W4313343456 hasConcept C159167319 @default.
- W4313343456 hasConcept C159654299 @default.
- W4313343456 hasConcept C163764329 @default.
- W4313343456 hasConcept C169760540 @default.
- W4313343456 hasConcept C170493617 @default.
- W4313343456 hasConcept C195616568 @default.
- W4313343456 hasConcept C203014093 @default.
- W4313343456 hasConcept C207001950 @default.
- W4313343456 hasConcept C2778868616 @default.
- W4313343456 hasConcept C2779134260 @default.
- W4313343456 hasConcept C513476851 @default.
- W4313343456 hasConcept C55493867 @default.
- W4313343456 hasConcept C71924100 @default.
- W4313343456 hasConcept C86803240 @default.
- W4313343456 hasConcept C95444343 @default.
- W4313343456 hasConceptScore W4313343456C126322002 @default.
- W4313343456 hasConceptScore W4313343456C137183658 @default.
- W4313343456 hasConceptScore W4313343456C150903083 @default.
- W4313343456 hasConceptScore W4313343456C153911025 @default.
- W4313343456 hasConceptScore W4313343456C159167319 @default.
- W4313343456 hasConceptScore W4313343456C159654299 @default.
- W4313343456 hasConceptScore W4313343456C163764329 @default.
- W4313343456 hasConceptScore W4313343456C169760540 @default.
- W4313343456 hasConceptScore W4313343456C170493617 @default.
- W4313343456 hasConceptScore W4313343456C195616568 @default.
- W4313343456 hasConceptScore W4313343456C203014093 @default.
- W4313343456 hasConceptScore W4313343456C207001950 @default.
- W4313343456 hasConceptScore W4313343456C2778868616 @default.
- W4313343456 hasConceptScore W4313343456C2779134260 @default.
- W4313343456 hasConceptScore W4313343456C513476851 @default.
- W4313343456 hasConceptScore W4313343456C55493867 @default.
- W4313343456 hasConceptScore W4313343456C71924100 @default.
- W4313343456 hasConceptScore W4313343456C86803240 @default.
- W4313343456 hasConceptScore W4313343456C95444343 @default.
- W4313343456 hasIssue "1_Supplement" @default.
- W4313343456 hasLocation W43133434561 @default.
- W4313343456 hasOpenAccess W4313343456 @default.
- W4313343456 hasPrimaryLocation W43133434561 @default.
- W4313343456 hasRelatedWork W1994889999 @default.
- W4313343456 hasRelatedWork W1995921812 @default.
- W4313343456 hasRelatedWork W2003244583 @default.
- W4313343456 hasRelatedWork W2026881390 @default.
- W4313343456 hasRelatedWork W2049542667 @default.
- W4313343456 hasRelatedWork W2053855000 @default.
- W4313343456 hasRelatedWork W2072433126 @default.
- W4313343456 hasRelatedWork W2410969896 @default.
- W4313343456 hasRelatedWork W28112173 @default.
- W4313343456 hasRelatedWork W2995040851 @default.
- W4313343456 hasVolume "184" @default.
- W4313343456 isParatext "false" @default.
- W4313343456 isRetracted "false" @default.
- W4313343456 workType "article" @default.