Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313343488> ?p ?o ?g. }
- W4313343488 endingPage "5728" @default.
- W4313343488 startingPage "5719" @default.
- W4313343488 abstract "Abstract TGF-β has been shown to play a central role in regulating inflammatory responses; thus, understanding the factors involved in the generation of TGF-β-producing cells could lead to interventions that are useful in effecting disease progression. In initial studies, the capacity of naive CD4+ T cells from TCR transgenic (Tg) mice to produce TGF-β following primary and secondary stimulation was assessed. TGF-β, IL-4, or IFN-γ production could not be detected from highly purified naive CD4+/lymphocyte endothelial cell adhesion molecule (LECAM)-1high cells following primary stimulation for 36 h with plate-bound anti-CD3, anti-CD28, and IL-2. This population was subsequently used to study the differentiation of TGF-β-producing CD4+ T cells. In further studies, naive CD4+/LECAM-1high cells from TCR transgenic mice of both the BALB/c and B10.A backgrounds were stimulated with T-depleted spleen cells (TDS) and specific peptide in the presence of various cytokines and/or cytokine antagonists for 5 days, restimulated, and TGF-β, IL-4, and IFN-γ production were measured. Priming conditions favoring high IL-4 production and/or low IFN-γ production greatly enhanced TGF-β production in secondary cultures. Furthermore, the presence of IL-10 in cultures was associated with an increase in TGF-β production following restimulation. The importance of IL-4 and IFN-γ in regulating TGF-β production was confirmed in studies showing that cells from IFN-γ−/− mice produced more TGF-β, while cells from IL-4−/− mice produced less TGF-β compared with wild-type controls. Finally, the addition of exogenous TGF-β to priming cultures significantly enhanced the production of TGF-β upon restimulation, demonstrating that TGF-β has a role in self-regulating its own production." @default.
- W4313343488 created "2023-01-06" @default.
- W4313343488 creator A5036378144 @default.
- W4313343488 creator A5046821514 @default.
- W4313343488 creator A5053370481 @default.
- W4313343488 creator A5055488196 @default.
- W4313343488 creator A5061200264 @default.
- W4313343488 creator A5081070073 @default.
- W4313343488 creator A5091034692 @default.
- W4313343488 date "1998-06-15" @default.
- W4313343488 modified "2023-10-10" @default.
- W4313343488 title "Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production" @default.
- W4313343488 cites W1484049504 @default.
- W4313343488 cites W1502749381 @default.
- W4313343488 cites W1503388237 @default.
- W4313343488 cites W1526621387 @default.
- W4313343488 cites W1547565061 @default.
- W4313343488 cites W1570035884 @default.
- W4313343488 cites W1600526298 @default.
- W4313343488 cites W1634158134 @default.
- W4313343488 cites W1638931088 @default.
- W4313343488 cites W1845629018 @default.
- W4313343488 cites W1898802354 @default.
- W4313343488 cites W1970959631 @default.
- W4313343488 cites W1971994001 @default.
- W4313343488 cites W1979514172 @default.
- W4313343488 cites W1979657237 @default.
- W4313343488 cites W1985323653 @default.
- W4313343488 cites W1988317772 @default.
- W4313343488 cites W1992985178 @default.
- W4313343488 cites W2005246059 @default.
- W4313343488 cites W2022606988 @default.
- W4313343488 cites W2032980904 @default.
- W4313343488 cites W2045312135 @default.
- W4313343488 cites W2056859114 @default.
- W4313343488 cites W2070379407 @default.
- W4313343488 cites W2078025711 @default.
- W4313343488 cites W2079140747 @default.
- W4313343488 cites W2089262366 @default.
- W4313343488 cites W2118202213 @default.
- W4313343488 cites W2118857294 @default.
- W4313343488 cites W2121473086 @default.
- W4313343488 cites W2128707261 @default.
- W4313343488 cites W2134453100 @default.
- W4313343488 cites W2139144899 @default.
- W4313343488 cites W2141679700 @default.
- W4313343488 cites W2154122248 @default.
- W4313343488 cites W2161916137 @default.
- W4313343488 cites W2163682172 @default.
- W4313343488 cites W2165885428 @default.
- W4313343488 doi "https://doi.org/10.4049/jimmunol.160.12.5719" @default.
- W4313343488 hasPublicationYear "1998" @default.
- W4313343488 type Work @default.
- W4313343488 citedByCount "94" @default.
- W4313343488 countsByYear W43133434882012 @default.
- W4313343488 countsByYear W43133434882013 @default.
- W4313343488 countsByYear W43133434882014 @default.
- W4313343488 countsByYear W43133434882015 @default.
- W4313343488 countsByYear W43133434882017 @default.
- W4313343488 countsByYear W43133434882018 @default.
- W4313343488 countsByYear W43133434882021 @default.
- W4313343488 crossrefType "journal-article" @default.
- W4313343488 hasAuthorship W4313343488A5036378144 @default.
- W4313343488 hasAuthorship W4313343488A5046821514 @default.
- W4313343488 hasAuthorship W4313343488A5053370481 @default.
- W4313343488 hasAuthorship W4313343488A5055488196 @default.
- W4313343488 hasAuthorship W4313343488A5061200264 @default.
- W4313343488 hasAuthorship W4313343488A5081070073 @default.
- W4313343488 hasAuthorship W4313343488A5091034692 @default.
- W4313343488 hasBestOaLocation W43133434881 @default.
- W4313343488 hasConcept C100701293 @default.
- W4313343488 hasConcept C118131993 @default.
- W4313343488 hasConcept C129374314 @default.
- W4313343488 hasConcept C148125776 @default.
- W4313343488 hasConcept C153911025 @default.
- W4313343488 hasConcept C154317977 @default.
- W4313343488 hasConcept C202751555 @default.
- W4313343488 hasConcept C203014093 @default.
- W4313343488 hasConcept C2776090121 @default.
- W4313343488 hasConcept C2778690821 @default.
- W4313343488 hasConcept C2908647359 @default.
- W4313343488 hasConcept C39347974 @default.
- W4313343488 hasConcept C55493867 @default.
- W4313343488 hasConcept C59822182 @default.
- W4313343488 hasConcept C71924100 @default.
- W4313343488 hasConcept C81444415 @default.
- W4313343488 hasConcept C86803240 @default.
- W4313343488 hasConcept C8891405 @default.
- W4313343488 hasConcept C95444343 @default.
- W4313343488 hasConcept C99454951 @default.
- W4313343488 hasConceptScore W4313343488C100701293 @default.
- W4313343488 hasConceptScore W4313343488C118131993 @default.
- W4313343488 hasConceptScore W4313343488C129374314 @default.
- W4313343488 hasConceptScore W4313343488C148125776 @default.
- W4313343488 hasConceptScore W4313343488C153911025 @default.
- W4313343488 hasConceptScore W4313343488C154317977 @default.
- W4313343488 hasConceptScore W4313343488C202751555 @default.
- W4313343488 hasConceptScore W4313343488C203014093 @default.