FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313343491> ?p ?o ?g. }

• W4313343491 endingPage "3932" @default.
• W4313343491 startingPage "3926" @default.
• W4313343491 abstract "Abstract Great attention has been placed on the possibility of distinguishing Th1 from Th2 cells on the basis of differential expression of surface receptors. We have recently shown that the differential expression of the IL-12Rβ2 chain in Th1 and Th2 cells, as measured at the mRNA level, accounts for an important regulatory mechanism in the differentiation of the two cell subsets. In this study, we identify IL-12R expression at the protein level. We have generated an anti-IL-12Rβ2-specific mAb and analyzed IL-12Rβ2 expression on polarized Th cell populations generated in vitro and on T cells derived from patients with Th1- or Th2-mediated inflammatory conditions. Although IL-12Rβ2 was absent in freshly isolated PBMC and in cord blood cells, we were able to detect IL-12Rβ2 expression selectively in differentiated Th1 and T cytotoxic 1, but not Th2 or T cytotoxic 2 cells. In the presence of IL-12, cell surface expression of the IL-12Rβ2 subunit was readily detected on T cells after 24 h, reached the maximum at day 5, and declined thereafter. Most importantly, the anti-IL-12Rβ2 mAb recognizes lung T cells from patients with sarcoidosis, a disease characterized by a typical cell-mediated, Th1-type inflammatory response. In contrast, IL-12Rβ2 was absent in lung T cells from patients with allergic asthma, a disease characterized by a Th2-type inflammatory response. The mAb reported in this study should represent a powerful tool to investigate the role of Th1 and Th2 cells in inflammatory conditions and to monitor therapies aimed at altering the balance of Th cell subsets." @default.
• W4313343491 created "2023-01-06" @default.
• W4313343491 creator A5011398547 @default.
• W4313343491 creator A5012421737 @default.
• W4313343491 creator A5014932220 @default.
• W4313343491 creator A5021147650 @default.
• W4313343491 creator A5030660777 @default.
• W4313343491 creator A5044143952 @default.
• W4313343491 creator A5044632482 @default.
• W4313343491 creator A5056984231 @default.
• W4313343491 creator A5069083837 @default.
• W4313343491 creator A5087722204 @default.
• W4313343491 date "1999-04-01" @default.
• W4313343491 modified "2023-10-17" @default.
• W4313343491 title "Antibodies to the IL-12 Receptor β2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo" @default.
• W4313343491 cites W1531605330 @default.
• W4313343491 cites W1552337371 @default.
• W4313343491 cites W1565959221 @default.
• W4313343491 cites W1604795805 @default.
• W4313343491 cites W1648671938 @default.
• W4313343491 cites W1661041446 @default.
• W4313343491 cites W1817153273 @default.
• W4313343491 cites W1829938205 @default.
• W4313343491 cites W1838853754 @default.
• W4313343491 cites W1898357572 @default.
• W4313343491 cites W191142670 @default.
• W4313343491 cites W1924633993 @default.
• W4313343491 cites W1942668068 @default.
• W4313343491 cites W1979514172 @default.
• W4313343491 cites W1980000158 @default.
• W4313343491 cites W1981418575 @default.
• W4313343491 cites W1984686364 @default.
• W4313343491 cites W1987292500 @default.
• W4313343491 cites W1988707760 @default.
• W4313343491 cites W2002726220 @default.
• W4313343491 cites W2004707896 @default.
• W4313343491 cites W2011499269 @default.
• W4313343491 cites W2027699993 @default.
• W4313343491 cites W2031501484 @default.
• W4313343491 cites W2040905464 @default.
• W4313343491 cites W2042952724 @default.
• W4313343491 cites W2044325609 @default.
• W4313343491 cites W2056859114 @default.
• W4313343491 cites W2067714902 @default.
• W4313343491 cites W2067989244 @default.
• W4313343491 cites W2075097313 @default.
• W4313343491 cites W2095351296 @default.
• W4313343491 cites W2102153142 @default.
• W4313343491 cites W2107860814 @default.
• W4313343491 cites W2109506765 @default.
• W4313343491 cites W2116641130 @default.
• W4313343491 cites W2117206496 @default.
• W4313343491 cites W2117342688 @default.
• W4313343491 cites W2139144899 @default.
• W4313343491 cites W2160129587 @default.
• W4313343491 cites W2161485037 @default.
• W4313343491 cites W2165588484 @default.
• W4313343491 cites W2175077154 @default.
• W4313343491 cites W2994597783 @default.
• W4313343491 cites W4235586515 @default.
• W4313343491 cites W4313333788 @default.
• W4313343491 doi "https://doi.org/10.4049/jimmunol.162.7.3926" @default.
• W4313343491 hasPublicationYear "1999" @default.
• W4313343491 type Work @default.
• W4313343491 citedByCount "82" @default.
• W4313343491 countsByYear W43133434912012 @default.
• W4313343491 countsByYear W43133434912014 @default.
• W4313343491 countsByYear W43133434912015 @default.
• W4313343491 countsByYear W43133434912016 @default.
• W4313343491 countsByYear W43133434912017 @default.
• W4313343491 countsByYear W43133434912018 @default.
• W4313343491 countsByYear W43133434912022 @default.
• W4313343491 countsByYear W43133434912023 @default.
• W4313343491 crossrefType "journal-article" @default.
• W4313343491 hasAuthorship W4313343491A5011398547 @default.
• W4313343491 hasAuthorship W4313343491A5012421737 @default.
• W4313343491 hasAuthorship W4313343491A5014932220 @default.
• W4313343491 hasAuthorship W4313343491A5021147650 @default.
• W4313343491 hasAuthorship W4313343491A5030660777 @default.
• W4313343491 hasAuthorship W4313343491A5044143952 @default.
• W4313343491 hasAuthorship W4313343491A5044632482 @default.
• W4313343491 hasAuthorship W4313343491A5056984231 @default.
• W4313343491 hasAuthorship W4313343491A5069083837 @default.
• W4313343491 hasAuthorship W4313343491A5087722204 @default.
• W4313343491 hasBestOaLocation W43133434911 @default.
• W4313343491 hasConcept C153911025 @default.
• W4313343491 hasConcept C154317977 @default.
• W4313343491 hasConcept C185592680 @default.
• W4313343491 hasConcept C202751555 @default.
• W4313343491 hasConcept C203014093 @default.
• W4313343491 hasConcept C54355233 @default.
• W4313343491 hasConcept C86803240 @default.
• W4313343491 hasConcept C95444343 @default.
• W4313343491 hasConceptScore W4313343491C153911025 @default.
• W4313343491 hasConceptScore W4313343491C154317977 @default.
• W4313343491 hasConceptScore W4313343491C185592680 @default.
• W4313343491 hasConceptScore W4313343491C202751555 @default.
• W4313343491 hasConceptScore W4313343491C203014093 @default.

• next