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- W4313344511 endingPage "39.7" @default.
- W4313344511 startingPage "39.7" @default.
- W4313344511 abstract "Abstract Inflammatory bowel disease (IBD) is an autoimmune disease that affects the gastrointestinal tract. Vitamin D an immunoregulatory steroid hormone has been shown to have suppressive affects on IBD and vitamin D deficiency has been shown to have a direct correlation with the severity of inflammation in experimental models of the disease. Several regulatory cells including CD8αα + TCRαβ + T cells that are found in the epithelial layer of the gut, have been shown to suppress experimental models of IBD. Here we show that mice that lack the vitamin D receptor (VDR) or are vitamin D deficient have significantly reduced CD8αα + TCRαβ + T cells. When vitamin D is provided to deficient mice this population of T cells recovers. Precursors of CD8αα + TCRαβ + T cells in the thymus of VDR deficient mice appear to be normal. However, gut homing of the CD8αα + TCRαβ + T cells precursors is reduced. Those CD8αα + TCRαβ + T cells that are in the gut of mice that lack the VDR produce fewer cytokines and appear to be dysfunctional. Vitamin D and signaling through the VDR is required for the development of functional CD8αα + TCRαβ + T cells." @default.
- W4313344511 created "2023-01-06" @default.
- W4313344511 creator A5059431026 @default.
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- W4313344511 date "2009-04-01" @default.
- W4313344511 modified "2023-09-30" @default.
- W4313344511 title "Vitamin D is required for the development of functional CD8{alpha}{alpha} intestinal intraepithelial lymphocytes (39.7)" @default.
- W4313344511 doi "https://doi.org/10.4049/jimmunol.182.supp.39.7" @default.
- W4313344511 hasPublicationYear "2009" @default.
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