Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313344522> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313344522 endingPage "49.1" @default.
- W4313344522 startingPage "49.1" @default.
- W4313344522 abstract "Abstract Regulatory T (Treg) cells are essential for maintaining immune homeostasis and preventing autoimmune diseases. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that two members of the nuclear factor (NF)-κB family, i.e., c-Rel and p65 (also known as RelA), controlled the development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB. Although Smad and CREB first bound to Foxp3 enhancers, they later moved to the promoter to form the c-Rel enhanceosome. c-Rel-deficient mice had up to 90% reductions of Treg cells compared to wild-type mice, and c-Rel-deficient T cells were compromised in Treg cell differentiation. Thus, Treg cell development is controlled by a Foxp3-specific enhanceosome, and strategies targeting NF-κB can be effective for manipulating Treg cell function." @default.
- W4313344522 created "2023-01-06" @default.
- W4313344522 creator A5003375422 @default.
- W4313344522 creator A5016838540 @default.
- W4313344522 creator A5027475930 @default.
- W4313344522 creator A5030948663 @default.
- W4313344522 creator A5056703988 @default.
- W4313344522 creator A5068411698 @default.
- W4313344522 creator A5080935317 @default.
- W4313344522 creator A5089073198 @default.
- W4313344522 date "2010-04-01" @default.
- W4313344522 modified "2023-09-26" @default.
- W4313344522 title "Nuclear factor-κB drives the development of Foxp3+ regulatory T cells through the c-Rel enhanceosome (49.1)" @default.
- W4313344522 doi "https://doi.org/10.4049/jimmunol.184.supp.49.1" @default.
- W4313344522 hasPublicationYear "2010" @default.
- W4313344522 type Work @default.
- W4313344522 citedByCount "0" @default.
- W4313344522 crossrefType "journal-article" @default.
- W4313344522 hasAuthorship W4313344522A5003375422 @default.
- W4313344522 hasAuthorship W4313344522A5016838540 @default.
- W4313344522 hasAuthorship W4313344522A5027475930 @default.
- W4313344522 hasAuthorship W4313344522A5030948663 @default.
- W4313344522 hasAuthorship W4313344522A5056703988 @default.
- W4313344522 hasAuthorship W4313344522A5068411698 @default.
- W4313344522 hasAuthorship W4313344522A5080935317 @default.
- W4313344522 hasAuthorship W4313344522A5089073198 @default.
- W4313344522 hasConcept C104317684 @default.
- W4313344522 hasConcept C189938988 @default.
- W4313344522 hasConcept C203014093 @default.
- W4313344522 hasConcept C2779727006 @default.
- W4313344522 hasConcept C502942594 @default.
- W4313344522 hasConcept C54355233 @default.
- W4313344522 hasConcept C86339819 @default.
- W4313344522 hasConcept C86803240 @default.
- W4313344522 hasConcept C8891405 @default.
- W4313344522 hasConcept C95444343 @default.
- W4313344522 hasConceptScore W4313344522C104317684 @default.
- W4313344522 hasConceptScore W4313344522C189938988 @default.
- W4313344522 hasConceptScore W4313344522C203014093 @default.
- W4313344522 hasConceptScore W4313344522C2779727006 @default.
- W4313344522 hasConceptScore W4313344522C502942594 @default.
- W4313344522 hasConceptScore W4313344522C54355233 @default.
- W4313344522 hasConceptScore W4313344522C86339819 @default.
- W4313344522 hasConceptScore W4313344522C86803240 @default.
- W4313344522 hasConceptScore W4313344522C8891405 @default.
- W4313344522 hasConceptScore W4313344522C95444343 @default.
- W4313344522 hasIssue "1_Supplement" @default.
- W4313344522 hasLocation W43133445221 @default.
- W4313344522 hasOpenAccess W4313344522 @default.
- W4313344522 hasPrimaryLocation W43133445221 @default.
- W4313344522 hasRelatedWork W2002568035 @default.
- W4313344522 hasRelatedWork W2008844540 @default.
- W4313344522 hasRelatedWork W2017372504 @default.
- W4313344522 hasRelatedWork W2019077533 @default.
- W4313344522 hasRelatedWork W2082427996 @default.
- W4313344522 hasRelatedWork W2098788741 @default.
- W4313344522 hasRelatedWork W2116015828 @default.
- W4313344522 hasRelatedWork W2534348102 @default.
- W4313344522 hasRelatedWork W2801044204 @default.
- W4313344522 hasRelatedWork W4213139771 @default.
- W4313344522 hasVolume "184" @default.
- W4313344522 isParatext "false" @default.
- W4313344522 isRetracted "false" @default.
- W4313344522 workType "article" @default.