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- W4313344554 abstract "Abstract We previously showed that IL-18/IL-12 treatment of tumor bearing mice elicited significant anti-tumor activity concurrent with a decrease in the detectable number of invariant NKT (iNKT) cells. We now demonstrate that acute treatment with IL-18/IL-12 initially decreased the number of NK1.1(+) iNKT cells while α-GalCer decreased both NK1.1(+) and NK1.1(-) iNKT cells in the liver. Genomic qPCR analysis of iNKT cell's restricted Vα14Jα18 TCR confirmed the loss of cells at 24hrs in the liver rather than receptor down modulation. A small or no decrease in the genomic levels of Vα14Jα18 from other lymphoid tissues indicates the loss of iNKT cells from IL-18/IL-12 or α-GalCer treatment of mice was regulated by the liver microenvironment. Furthermore, an increase in AnnexinV was detected on liver iNKT cells following treatment with IL-18/IL-12 and an increase in cells that were tunnel positive was observed in the liver following α-GalCer treatment of mice. Although iNKT cells initially (24hrs) decrease in the liver following acute administration of α-GalCer or IL-18/IL-12, these cells subsequently (72hrs) reappear and expand in the liver. To study the expansion of iNKT cells in the liver, we administered BrdU to mice 24hrs after acute treatment with IL-18/IL-12 or α-GalCer and found a high percentage of proliferating liver iNKT cells were recent emigrating NK1.1(-) iNKT cells." @default.
- W4313344554 created "2023-01-06" @default.
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- W4313344554 date "2009-04-01" @default.
- W4313344554 modified "2023-09-30" @default.
- W4313344554 title "Acute inflammation with IL-18/IL-12 or α-GalCer treatment induces liver iNKT cell apoptosis and repopulation from peripheral tissues, whereas chronic inflammation ablates systemic iNKT cells with thymic-dependent repopulation (134.24)" @default.
- W4313344554 doi "https://doi.org/10.4049/jimmunol.182.supp.134.24" @default.
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