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- W4313344562 abstract "Abstract We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC). This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-κB inhibitor IκBα (mut-IκB) and to study the maturation defects occurring when NF-κB activation is inhibited during fetal development. Fetal thymocytes infected with adenovirus containing mut-IκB were found to develop normally until the CD44−CD25+, CD4−CD8− double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased. Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR β-chain. However, apoptosis was much higher in FTOC infected with adenovirus containing mut-IκB than in FTOC infected with a control virus. Taken together, these results suggest that NF-κB plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development." @default.
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- W4313344562 date "1999-03-15" @default.
- W4313344562 modified "2023-10-14" @default.
- W4313344562 title "Impaired Fetal Thymocyte Development After Efficient Adenovirus-Mediated Inhibition of NF-κB Activation" @default.
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- W4313344562 doi "https://doi.org/10.4049/jimmunol.162.6.3456" @default.
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