Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313344570> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313344570 endingPage "49.3" @default.
- W4313344570 startingPage "49.3" @default.
- W4313344570 abstract "Abstract While TGF-β is essential for the development of peripherally induced Foxp3+ regulatory T (iTreg) and Th17 cells, the intracellular signaling mechanism by which TGF-β regulates development of both cell subsets is less well understood. Using Smad2 lymphocyte conditional knock out and Smad3 knock out mice, we report that neither Smad2 nor Smad3 deficiency abrogates TGF-β-dependent iTreg induction by a deacetylase inhibitor Trichostatin A (TsA) in vivo although loss of Smad2 or Smad3 partially reduces iTreg induction in vitro. Similarly, Smad2 and Smad3 have a redundant role in development of Th17 in vitro and in experimental autoimmune encephalomyelitis (EAE). In addition, ERK and/or JNK pathways were shown to be involved in regulating iTregs, while the p38 pathway predominately modulates Th17 and EAE induction. Therefore, selective targeting of these intracellular TGF-β signaling pathways during iTreg and Th17 cell development may lead to the development of therapies in treating autoimmune and other chronic inflammatory diseases." @default.
- W4313344570 created "2023-01-06" @default.
- W4313344570 creator A5011166102 @default.
- W4313344570 creator A5022895653 @default.
- W4313344570 creator A5025668076 @default.
- W4313344570 creator A5031674948 @default.
- W4313344570 creator A5050461137 @default.
- W4313344570 creator A5052274720 @default.
- W4313344570 creator A5074402502 @default.
- W4313344570 creator A5087253610 @default.
- W4313344570 creator A5089115356 @default.
- W4313344570 date "2010-04-01" @default.
- W4313344570 modified "2023-10-17" @default.
- W4313344570 title "Role of Smad and non-Smad signals in the development of Th17 and regulatory T cells (49.3)" @default.
- W4313344570 doi "https://doi.org/10.4049/jimmunol.184.supp.49.3" @default.
- W4313344570 hasPublicationYear "2010" @default.
- W4313344570 type Work @default.
- W4313344570 citedByCount "0" @default.
- W4313344570 crossrefType "journal-article" @default.
- W4313344570 hasAuthorship W4313344570A5011166102 @default.
- W4313344570 hasAuthorship W4313344570A5022895653 @default.
- W4313344570 hasAuthorship W4313344570A5025668076 @default.
- W4313344570 hasAuthorship W4313344570A5031674948 @default.
- W4313344570 hasAuthorship W4313344570A5050461137 @default.
- W4313344570 hasAuthorship W4313344570A5052274720 @default.
- W4313344570 hasAuthorship W4313344570A5074402502 @default.
- W4313344570 hasAuthorship W4313344570A5087253610 @default.
- W4313344570 hasAuthorship W4313344570A5089115356 @default.
- W4313344570 hasConcept C185592680 @default.
- W4313344570 hasConcept C203014093 @default.
- W4313344570 hasConcept C2778486448 @default.
- W4313344570 hasConcept C2779727006 @default.
- W4313344570 hasConcept C2781080636 @default.
- W4313344570 hasConcept C502942594 @default.
- W4313344570 hasConcept C57074206 @default.
- W4313344570 hasConcept C62478195 @default.
- W4313344570 hasConcept C79879829 @default.
- W4313344570 hasConcept C86803240 @default.
- W4313344570 hasConcept C8891405 @default.
- W4313344570 hasConcept C95444343 @default.
- W4313344570 hasConceptScore W4313344570C185592680 @default.
- W4313344570 hasConceptScore W4313344570C203014093 @default.
- W4313344570 hasConceptScore W4313344570C2778486448 @default.
- W4313344570 hasConceptScore W4313344570C2779727006 @default.
- W4313344570 hasConceptScore W4313344570C2781080636 @default.
- W4313344570 hasConceptScore W4313344570C502942594 @default.
- W4313344570 hasConceptScore W4313344570C57074206 @default.
- W4313344570 hasConceptScore W4313344570C62478195 @default.
- W4313344570 hasConceptScore W4313344570C79879829 @default.
- W4313344570 hasConceptScore W4313344570C86803240 @default.
- W4313344570 hasConceptScore W4313344570C8891405 @default.
- W4313344570 hasConceptScore W4313344570C95444343 @default.
- W4313344570 hasIssue "1_Supplement" @default.
- W4313344570 hasLocation W43133445701 @default.
- W4313344570 hasOpenAccess W4313344570 @default.
- W4313344570 hasPrimaryLocation W43133445701 @default.
- W4313344570 hasRelatedWork W2000047140 @default.
- W4313344570 hasRelatedWork W2027244603 @default.
- W4313344570 hasRelatedWork W2042135836 @default.
- W4313344570 hasRelatedWork W2078792455 @default.
- W4313344570 hasRelatedWork W2317049313 @default.
- W4313344570 hasRelatedWork W2352788820 @default.
- W4313344570 hasRelatedWork W2381340599 @default.
- W4313344570 hasRelatedWork W2384817912 @default.
- W4313344570 hasRelatedWork W2462039273 @default.
- W4313344570 hasRelatedWork W2889136656 @default.
- W4313344570 hasVolume "184" @default.
- W4313344570 isParatext "false" @default.
- W4313344570 isRetracted "false" @default.
- W4313344570 workType "article" @default.