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- W4313344573 abstract "Abstract Foxp3+ regulatory T cells (Tregs) express both ectoenzymes CD39 and CD73, which in tandem hydrolyze pericellular ATP into adenosine, an immunoinhibitory molecule that contributes to Treg suppressive function. Using Foxp3GFP knockin mice, we noted that the mouse CD4+CD39+ T cell pool contains two roughly equal size Foxp3+ and Foxp3- populations. While Foxp3+CD39+ cells are CD73bright and are the bone fide Tregs, Foxp3-CD39+ cells are CD44+CD62L-CD25-CD73dim/-, exhibiting memory cell phenotype. Compared with Foxp3-CD39- naïve T cells, Foxp3-CD39+ cells freshly isolated from non-immunized mice express strikingly higher levels of mRNA for T helper lineage specific cytokines IFN-γ (Th1), IL-4/IL-10 (Th2), IL-17A/F (Th17), as well as pro-inflammatory cytokines IL-1, IL-6, TNF-α, and MCP-1. Upon stimulation, Foxp3-CD39+ but not Foxp3-CD39- cells rapidly secrete these cytokines. Moreover, the presence of Foxp3-CD39+ cells inhibits TGF-β-induced conversion of Foxp3-CD39- cells into iTregs. Thus, CD39 denotes both Treg and pre-existing memory T cells of Th1-, Th2-, and Th17-types." @default.
- W4313344573 created "2023-01-06" @default.
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- W4313344573 date "2009-04-01" @default.
- W4313344573 modified "2023-09-26" @default.
- W4313344573 title "Isolated CD39 Expression On CD4+ T Cells Denotes Both Regulatory and Memory Populations (47.26)" @default.
- W4313344573 doi "https://doi.org/10.4049/jimmunol.182.supp.47.26" @default.
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